Results 81 to 90 of about 37,375 (191)

Vivid views of the PINK1 protein [PDF]

Nature, 2017
Structures of an unusual enzymatic domain in PINK1 provide insights into how this protein regulates the function of organelles called mitochondria, and how mutations in PINK1 contribute to Parkinson’s disease. Structures of an unusual enzymatic domain in PINK1 provide insights into how this protein regulates the function of organelles called ...
Salima, Daou, Frank, Sicheri
openaire   +2 more sources

PINK1 deficiency impairs osteoblast differentiation through aberrant mitochondrial homeostasis

Stem Cell Research & Therapy, 2021
Background PTEN-induced kinase 1 (PINK1) is a serine/threonine-protein kinase in mitochondria that is critical for mitochondrial quality control.
So-Young Lee, Hyun-Ju An, Jin Man Kim, Min-Ji Sung, Do Kyung Kim, Hyung Kyung Kim, Jongbeom Oh, Hye Yun Jeong, Yu Ho Lee, Taeyoung Yang, Jun Han Kim, Ha Jeong Lim, Soonchul Lee   +12 more
doaj   +1 more source

Protective effects of Buyinqianzheng Formula on mitochondrial morphology by PINK1/Parkin pathway in SH-SY5Y cells induced by MPP+

Journal of Traditional Chinese Medical Sciences, 2020
Objective: Buyinqianzheng Formula (BYQZF) is clinically employed in traditional Chinese medicine to treat Parkinson’s disease (PD) by improving mitochondrial dysfunction.
Haojie Ma, Zhenyu Guo, Cong Gai, Cuicui Cheng, Jinkun Zhang, Yuxin Zhang, Luping Yang, Wandi Feng, Yushan Gao, Hongmei Sun   +9 more
doaj   +1 more source

Distinct Mechanisms of Pathogenic DJ-1 Mutations in Mitochondrial Quality Control [PDF]

, 2018
The deglycase and chaperone protein DJ-1 is pivotal for cellular oxidative stress responses and mitochondrial quality control. Mutations in PARK7, encoding DJ-1, are associated with early-onset familial Parkinson’s disease and lead to pathological ...
Abeti, Abou-Sleiman, Adam-Vizi, Alexis A. Robinson, Ariga, Banerjee, Ben-Nissan, Blackinton, Boland, Bonifati, Bonifati, Brenner-Lavie, Campanella, Canet-Avilés, Cannon, Carlo Rodolfo, Caterina Ferraina, Chen, Daniela Strobbe, Dauer, Dias, Duchen, D’Autréaux, East, Gatliff, Georgakopoulos, Giaime, Giordano, Görner, Harvey, Hulleman, Junn, Kahle, Kim, Kirsten Harvey, Lakshminarasimhan, Lara Rossi, Lücking, Maita, Martinat, Martinez-Vicente, Matic, Michelangelo Campanella, Moscovitz, Muller, Murphy, Narendra, Niki, Olzmann, Ono, Onyango, Paisán-Ruíz, Pankratz, Parker, Parsanejad, Polymeropoulos, Robert J. Harvey, Schon, Shendelman, Shinbo, Taira, Takahashi, Takahashi-Niki, Valente, Valerio de Biase, Waak, Wang   +66 more
core   +3 more sources

Endorepellin remodels the endothelial transcriptome toward a pro-autophagic and pro-mitophagic gene signature. [PDF]

, 2018
Regulation of autophagy by proteolytically cleaved fragments of heparan sulfate proteoglycans is a novel and current research focus in tumor biology. Endorepellin is the C-terminal angiostatic fragment of the heparan sulfate proteoglycan perlecan and ...
Andreuzzi, Eva, Iozzo, Renato V., Mongiat, Maurizo, Neill, Thomas, Peiper, Stephen C., Wang, Zi-Xuan   +5 more
core   +1 more source

Role of mitophagy in spinal cord ischemia-reperfusion injury

Neural Regeneration Research
Spinal cord ischemia-reperfusion injury, a severe form of spinal cord damage, can lead to sensory and motor dysfunction. This injury often occurs after traumatic events, spinal cord surgeries, or thoracoabdominal aortic surgeries.
Yanni Duan, Fengguang Yang, Yibao Zhang, Mingtao Zhang, Yujun Shi, Yun Lang, Hongli Sun, Xin Wang, Hongyun Jin, Xuewen Kang   +9 more
doaj   +1 more source

Dissecting PINK1/parkin mitophagy dynamics

, 2022
Mitochondria homeostasis is crucial for cellular integrity. Several quality control mechanisms can revert mitochondrial damage. However, in situations of acute and irreversible mitochondrial stress, specific pathways are activated to promote the selective degradation of mitochondria: mitophagy.
openaire   +2 more sources

The role of mitophagy in periodontitis bone tissue

Kouqiang hemian waike zazhi
[Objective:] To investigate changes in mitophagy levels in bone tissue during periodontitis in mice and to explore the effects of lipopolysaccharide (LPS)-induced mitophagy on the osteogenic differentiation capacity of mouse embryonic osteoblast ...
CAI Yuyi, WANG Haicheng, SUN Bin, XU Yifan, WANG Zuolin   +4 more
doaj   +1 more source

αSynuclein control of mitochondrial homeostasis in human-derived neurons is disrupted by mutations associated with Parkinson’s disease [PDF]

, 2017
The etiology of Parkinson’s disease (PD) converges on a common pathogenic pathway of mitochondrial defects in which α-Synuclein (αSyn) is thought to play a role.
Alloatti, Matías, Cromberg, Lucas Eneas, Dimopoulos, Nicolás, Falzone, Tomas Luis, Marin Burgin, Antonia, Otero, Maria Gabriela, Pardi, María Belén, Pozo Devoto, Victorio Martin, Saez, Trinidad María de Los Milagros, Scassa, Maria Elida, Schinder, Alejandro Fabián, Sevlever, Gustavo, Stokin, Gorazd B.   +12 more
core   +1 more source

PINK1 mutants associated with recessive Parkinson’s disease are defective in inhibiting mitochondrial release of cytochrome c

Neurobiology of Disease, 2007
Mutations in PTEN-induced kinase 1 (PINK1) gene cause recessive familial type 6 of Parkinson’s disease (PARK6). We investigated molecular mechanisms underlying PINK1 neuroprotective function and PARK6 mutation-induced loss of PINK1 function ...
Hung-Li Wang, An-Hsun Chou, Tu-Hsueh Yeh, Allen H. Li, Ying-Ling Chen, Yu-Li Kuo, Shu-Ru Tsai, Szu-Tzu Yu   +7 more
doaj   +1 more source