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Induction of PINK1/Parkin-Mediated Mitophagy
2017PINK1/Parkin mitophagy is a key mechanism to contribute mitochondrial quality control, and the defects are thought to be a cause of those Parkinson's disease onsets. Upon loss of mitochondrial membrane potential, PINK1 and Parkin are activated to promote the proteasomal degradation of mitochondrial outer membrane proteins and selective elimination of ...
Shigeto, Sato, Norihiko, Furuya
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iPS models of Parkin and PINK1
Biochemical Society Transactions, 2015Parkinson disease (PD) is a degenerative disorder of the central nervous system resulting from depletion of dopaminergic neurons and currently remains incurable despite enormous international research efforts. The development of induced pluripotent stem cell (iPSC) technology opened up the unique possibility of studying disease mechanisms in human ...
Aleksandar, Rakovic +2 more
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[Molecular genetics of PINK1].
Brain and nerve = Shinkei kenkyu no shinpo, 2007PTEN-induced putative kinase 1 (PINK1) is a causative gene for autosomal recessive early onset parkinsonism. Mutations in PINK1 were identified originally in PARK6-linked parkinsonism families from Italy and Spain. PINK1 contains 8 exons spanning 1.8 kb, and encodes a protein of 581 amino acids with a mitochondrial targeting motif and a serine ...
Manabu, Funayama, Nobutaka, Hattori
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PINK1: Multiple mechanisms of neuroprotection
2021Britney N, Lizama +2 more
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Autophagy
Mutations in the PINK1 kinase cause Parkinson disease (PD) through physiological processes that are not yet fully elucidated. PINK1 kinase accumulates selectively on damaged mitochondria, where it recruits the E3 ubiquitin ligase PRKN/Parkin to mediate mitophagy.
Mohamed A. Eldeeb +5 more
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Mutations in the PINK1 kinase cause Parkinson disease (PD) through physiological processes that are not yet fully elucidated. PINK1 kinase accumulates selectively on damaged mitochondria, where it recruits the E3 ubiquitin ligase PRKN/Parkin to mediate mitophagy.
Mohamed A. Eldeeb +5 more
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