Results 111 to 120 of about 58,639 (259)
Journal of Biological Chemistry, 2019 Ras genes potently drive human cancers, with mutated proto-oncogene GTPase KRAS4B (K-Ras4B) being the most abundant isoform. Targeted inhibition of oncogenic gene products is considered the “holy grail” of present-day cancer therapy, and recent ...
S. Cao +5 more
semanticscholar +1 more source
British Journal of Pharmacology, EarlyView.Theorized mechanism of dopamine homeostasis restoration in the nucleus accumbens core induced by a psychedelic intervention. Abstract Psychedelics have garnered great attention in recent years as treatments for major depressive disorder (MDD) and treatment‐resistant depression because of their ability to alter consciousness and afflicted cognitive ...
Lucas Wittenkeller +3 more
wiley +1 more source
Dynamic change of electrostatic field in TMEM16F permeation pathway shifts its ion selectivity. [PDF]
, 2019 TMEM16F is activated by elevated intracellular Ca2+, and functions as a small-conductance ion channel and as a phospholipid scramblase. In contrast to its paralogs, the TMEM16A/B calcium-activated chloride channels, mouse TMEM16F has been reported as a ...
Han, Tina W +4 more
core +2 more sources
The potential for biased signalling in the P2Y receptor family of GPCRs
British Journal of Pharmacology, EarlyView.The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk +2 more
wiley +1 more source
Evolutionary fine-tuning of conformational ensembles in FimH during host-pathogen interactions [PDF]
, 2017 Positive selection in the two-domain type 1 pilus adhesin FimH enhances Escherichia coli fitness in urinary tract infection (UTI). We report a comprehensive atomic-level view of FimH in two-state conformational ensembles in solution, composed of one low ...
Dodson, Karen W +11 more
core +3 more sources
PIP2 depletion promotes TRPV4 channel activity in mouse brain capillary endothelial cells
eLife, 2018 We recently reported that the inward-rectifier Kir2.1 channel in brain capillary endothelial cells (cECs) plays a major role in neurovascular coupling (NVC) by mediating a neuronal activity-dependent, propagating vasodilatory (hyperpolarizing) signal. We
O. Harraz +3 more
semanticscholar +1 more source
Spectroscopic characterization of PTEN/PIP2 interaction
The FASEB Journal, 2006 PTEN, a phosphatase that dephosphorylates the 3′ position of phosphoinositides, is a tumor suppressor. Activation of PTEN by PI‐4,5‐P 2 requires a polybasic region at the N‐terminus. It was hypothesized that PI‐4,5‐P 2 aids membrane recruiting and ...
Arne Gericke +4 more
openaire +1 more source
Cell Reports, 2019 Summary: Activation of Gαq-coupled receptors by inflammatory mediators inhibits cold-sensing TRPM8 channels, aggravating pain and inflammation. Both Gαq and the downstream hydrolysis of phosphatidylinositol 4, 5-bisphosphate (PIP2) inhibit TRPM8. Here, I
Xuming Zhang
doaj +1 more source
Sensing of cardiolipin exposure on plasma membranes of apoptotic cells by EryA‐mCherry protein
The FEBS Journal, EarlyView.An aegerolysin protein erylysin A (EryA) fused with mCherry binds to artificial lipid vesicles supplemented with cardiolipin (CL). This binding is much more specific than that of annexin V, which binds various negatively charged glycerophospholipids (PG, PS, PI). In mammalian cells, the CL exposition at the membrane surface represents an early hallmark
Luka Žeželj +12 more
wiley +1 more source
Below the NK-cell surface: PIP2
Blood, 2008 In this issue Blood, Micucci and colleagues demonstrate that PIP2 plays an essential role in NK-cell cytotoxicity by controlling the release of lytic mediators at the NK cell-target interface.
openaire +3 more sources