Results 31 to 40 of about 58,639 (259)
Frontiers in Physiology, 2021 BIN1 (amphyphysin-II) is a structural protein involved in T-tubule (TT) formation and phosphatidylinositol-4,5-bisphosphate (PIP2) is responsible for localization of BIN1 to sarcolemma.
Junlan Zhou +16 more
doaj +1 more source
Communications Biology, 2023 Ultrahigh-resolution views of PIP2 in freeze-fractured plasma membranes of dendritic spines during induction of long-term depression reveal spatial and temporal cues set by PIP2 and reveal the molecular mechanisms behind the observed PIP2 ...
Sarah A. Hofbrucker-MacKenzie +4 more
doaj +1 more source
Relationship between membrane phosphatidylinositol-4,5-bisphosphate and receptor-mediated inhibition of native neuronal M channels [PDF]
, 2005 The relationship between receptor-induced membrane phosphatidylinositol-4'5'-bisphosphate (PIP2) hydrolysis and M-current inhibition was assessed in single-dissociated rat sympathetic neurons by simultaneous or parallel recording of membrane current and ...
Abogadie, FC +6 more
core +1 more source
Review of PIP2 in Cellular Signaling, Functions and Diseases
International Journal of Molecular Sciences, 2020 Phosphoinositides play a crucial role in regulating many cellular functions, such as actin dynamics, signaling, intracellular trafficking, membrane dynamics, and cell–matrix adhesion.
K. Mandal
semanticscholar +1 more source
Public-private partnership in disaster management:A case study of the Gold Coast [PDF]
, 2012 Hypoxemic respiratory failure of the neonatal organism involves increased acid sphingomyelinase (aSMase) activity and production of ceramide, a second messenger of a pro-inflammatory pathway that promotes increased vascular permeability, surfactant ...
Adam-Klages, Sabine +13 more
core +1 more source
The recruitment and activation of phosphatidylinositol 4-phosphate 5-kinases α critically regulate CD28-dependent signaling responses [PDF]
, 2013 CD28 costimulatory receptor is a crucial determinant of the outcome of T lymphocyte activation. The engagement of CD28 by its natural ligands, B7.1/CD80 or B7.2/CD86, expressed on the surface of professional APC, lowers T cell receptor (TCR) activation ...
Camperio, Cristina +6 more
core +1 more source
PIP2 Reshapes Membranes through Asymmetric Desorption [PDF]
Biophysical Journal, 2019 Phosphatidylinositol-4,5-bisphosphate (PIP2) is an important signaling lipid in eukaryotic cell plasma membranes, playing an essential role in diverse cellular processes. The headgroup of PIP2 is highly negatively charged, and this lipid displays a high critical micellar concentration compared to housekeeping phospholipid analogs.
Sankalp Shukla +4 more
openaire +2 more sources
The dynamic interplay of PIP2 and ATP in the regulation of the KATP channel
bioRxiv, 2021 ATP-sensitive potassium (KATP) channels couple the intracellular ATP concentration to insulin secretion. KATP channel activity is inhibited by ATP binding to the Kir6.2 tetramer and activated by phosphatidylinositol-4,5-bisphosphate (PIP2).
Tanadet Pipatpolkai +4 more
semanticscholar +1 more source
Voltage-Sensitive PIP2 Phosphatase Shows PIP2 Requirements for KCNQ and Ca2+ Channels [PDF]
Biophysical Journal, 2011 The four talks in this symposium highlight the dependence of ion channel function on membrane phospholipids and fatty acids. Although of low abundance (1-2%), the phosphoinositide phosphatidylinositol 4,5-bisphosphate (PIP2) is a signature lipid of plasma membranes.
Hille, Bertil +4 more
openaire +1 more source
Scientific Reports, 2022 Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2 or PIP2) regulates the activities of numerous membrane proteins, including diacylglycerol(DAG)-activated TRPC3/6/7 channels.
Masayuki X. Mori +10 more
doaj +1 more source