Results 61 to 70 of about 58,639 (259)

The pain of PIP2 [PDF]

Science-Business eXchange, 2014
A UNC Chapel Hill team has found a way to block multiple pain receptors by antagonizing the lipid kinase PIP5K1C. Although a PIP5K1C inhibitor alleviates chronic pain in multiple mouse models, the lethality of PIP5K1C mutations suggests that titrating the right dose will be key for safety.
openaire   +1 more source

Identification of phosphoinositide-associated microRNAs reveals candidates with potential roles in cancer signaling

AIMS Molecular Science
MicroRNAs (miRNAs) are key post-transcriptional regulators of gene expression and have been associated with pathological processes, including oncogenesis.
Jany Valdes, Jaime A. Ceja, Andrea Bayona, Enrique Castaño de la Serna   +3 more
doaj   +1 more source

Limited Proteolysis-Coupled Mass Spectrometry Identifies Phosphatidylinositol 4,5-Bisphosphate Effectors in Human Nuclear Proteome

Cells, 2021
Specific nuclear sub-compartments that are regions of fundamental processes such as gene expression or DNA repair, contain phosphoinositides (PIPs). PIPs thus potentially represent signals for the localization of specific proteins into different nuclear ...
Martin Sztacho, Barbora Šalovská, Jakub Červenka, Can Balaban, Peter Hoboth, Pavel Hozák   +5 more
doaj   +1 more source

Skap2 is required for β2 integrin-mediated neutrophil recruitment and functions. [PDF]

, 2017
Integrin activation is required for neutrophil functions. Impaired integrin activation on neutrophils is the hallmark of leukocyte adhesion deficiency (LAD) syndrome in humans, characterized by impaired leukocyte recruitment and recurrent infections. The
Bardel, Bernadette, Block, Helena, Bokemeyer, Arne, Boras, Mark, Heitplatz, Barbara, Kliche, Stefanie, Lowell, Clifford, Reinhold, Annegret, Rossaint, Jan, Van Marck, Veerle, Volmering, Stephanie, Zarbock, Alexander   +11 more
core   +2 more sources

Molecular Sensors and Modulators of Thermoreception [PDF]

, 2015
Peer ...
Zhang, Xuming
core   +1 more source

Molecular mechanism for bidirectional regulation of CD44 for lipid raft affiliation by palmitoylations and PIP2

PLoS Comput. Biol., 2020
The co-localization of Cluster-of-Differentiation-44 protein (CD44) and cytoplasmic adaptors in specific membrane environments is crucial for cell adhesion and migration. The process is controlled by two different pathways: On the one hand palmitoylation
Fude Sun, C. Schroer, Carlos Ramírez-Palacios, Lida Xu, S. Luo, S. Marrink   +5 more
semanticscholar   +1 more source

Molecular Basis of Pip2 Gating KirBac1.1 [PDF]

Biophysical Journal, 2012
KirBac1.1 is a bacterial inward rectifier potassium (Kir) channel, which, in contrast to its eukaryotic homologues, is strongly inhibited by phosphatidylinositol-4,5-bisphosphate (PIP2). Previously, we labeled introduced cysteines in the KirBac1.1 cytoplasmic domain with small molecule fluorophores to examine PIP2 dependent structural rearrangements by
Wang, Shizhen, Heyman, Sarah, Enkvetchakul, Decha, Nichols, Colin G.   +3 more
openaire   +1 more source

Bidirectional transfer of homeoprotein EN2 across the plasma membrane requires PIP2

Journal of Cell Science, 2020
Homeoproteins are a class of transcription factors sharing the unexpected property of intercellular trafficking that confers to homeoproteins a paracrine mode of action.
Irène Amblard, E. Dupont, I. Alves, Julie Miralvès, I. Queguiner, A. Joliot   +5 more
semanticscholar   +1 more source

GCGR PIP2 interaction data nMS

, 2022
Native Mass Spectra of GCGR and phospholipids, POPS, POPA, POPG, and PI(4,5)P2.
Yan, Jun, Sørensen, Lars
openaire   +1 more source

Interplay Between Lipid Modulators of Kir2 Channels: Cholesterol and PIP2

Computational and Structural Biotechnology Journal, 2014
We have shown earlier that Kir2 channels are suppressed by the elevation of membrane cholesterol. Moreover, it is also well known that activation of Kir channels is critically dependent on a regulatory phospholipid, phosphatidylinositol-4,5-bisphosphate (
Avia Rosenhouse-Dantsker, Yulia Epshtein, Irena Levitan   +2 more
doaj   +1 more source