Results 81 to 90 of about 58,639 (259)

Editorial: Membrane lipids in T cell functions [PDF]

, 2018
Plasma membrane lipids play essential roles in regulating T cell signaling, differentiation, and effector functions. The major lipid species in the plasma membrane are glycerophospholipids, sphingolipids, and sterol lipids.
Tuosto, Loretta, Xu, Chenqi
core   +1 more source

Molecular basis of PIP2-dependent regulation of the Ca2+-activated chloride channel TMEM16A

Nature Communications, 2019
The calcium-activated chloride channel (CaCC) TMEM16A plays crucial roles in regulating neuronal excitability, smooth muscle contraction, fluid secretion and gut motility.
S. Le, Zhiguang Jia, Jianhan Chen, Huanghe Yang   +3 more
semanticscholar   +1 more source

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

The RNA-dependent association of phosphatidylinositol 4,5-bisphosphate with intrinsically disordered proteins contribute to nuclear compartmentalization.

PLoS Genetics
The RNA content is crucial for the formation of nuclear compartments, such as nuclear speckles and nucleoli. Phosphatidylinositol 4,5-bisphosphate (PIP2) is found in nuclear speckles, nucleoli, and nuclear lipid islets and is involved in RNA polymerase I/
Martin Sztacho, Jakub Červenka, Barbora Šalovská, Ludovica Antiga, Peter Hoboth, Pavel Hozák   +5 more
doaj   +1 more source

Modulating Integrin and Growth Factor Signaling With Peptides: Strategies to Synergistically Enhance Bone Tissue Regeneration

Advanced Science, EarlyView.
It has been demonstrated that, in the bone extracellular matrix (ECM), integrins and growth factor receptors (GFRs) engage in synergistic signaling to guide bone healing and regeneration. This review provides a comprehensive overview of current strategies using ECM‐derived peptides to recreate the cellular microenvironment and harness synergistic ...
Lluís Oliver‐Cervelló, Elisabetta Ada Cavalcanti‐Adam, Carlos Mas‐Moruno   +2 more
wiley   +1 more source

Optogenetic Control of PIP2 Interactions Shaping ENaC Activity

International Journal of Molecular Sciences, 2022
The activity of the epithelial Na+ Channel (ENaC) is strongly dependent on the membrane phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2). PIP2 binds two distinct cationic clusters within the N termini of β- and γ-ENaC subunits (βN1 and γN2). The affinities of these sites were previously determined using short synthetic peptides, yet their role
Tarek Mohamed Abd El-Aziz, Amanpreet Kaur, Mark S. Shapiro, James D. Stockand, Crystal R. Archer   +4 more
openaire   +2 more sources

Phosphoinositide-mediated oligomerization of a defensin induces cell lysis

eLife, 2014
Cationic antimicrobial peptides (CAPs) such as defensins are ubiquitously found innate immune molecules that often exhibit broad activity against microbial pathogens and mammalian tumor cells.
Ivan KH Poon, Amy A Baxter, Fung T Lay, Grant D Mills, Christopher G Adda, Jennifer AE Payne, Thanh Kha Phan, Gemma F Ryan, Julie A White, Prem K Veneer, Nicole L van der Weerden, Marilyn A Anderson, Marc Kvansakul, Mark D Hulett   +13 more
doaj   +1 more source

Novel Phosphotidylinositol 4,5-Bisphosphate Binding Sites on Focal Adhesion Kinase. [PDF]

PLoS ONE, 2015
Focal adhesion kinase (FAK) is a protein tyrosine kinase that is ubiquitously expressed, recruited to focal adhesions, and engages in a variety of cellular signaling pathways.
Jun Feng, Blake Mertz
doaj   +1 more source

Cantu syndrome–associated SUR2 (ABCC9) mutations in distinct structural domains result in KATP channel gain-of-function by differential mechanisms [PDF]

, 2018
The complex disorder Cantu syndrome (CS) arises from gainof-function mutations in either KCNJ8 or ABCC9, the genes encoding the Kir6.1 and SUR2 subunits of ATP-sensitive potassium (KATP) channels, respectively. Recent reports indicate that such mutations
Grange, Dorothy K., Hanson, Alex, Josifova, Dragana, McClenaghan, Conor, Nichols, Colin G., Roessler, Helen I., Sala-Rabanal, Monica, van Haaften, Gijs   +7 more
core   +2 more sources

PIP2 stabilises active states of GPCRs and enhances the selectivity of G-protein coupling

Nature, 2018
G-protein-coupled receptors (GPCRs) are involved in many physiological processes and are therefore key drug targets1. Although detailed structural information is available for GPCRs, the effects of lipids on the receptors, and on downstream coupling of ...
Hsin-Yung Yen, K. Hoi, I. Liko, G. Hedger, Michael r. Horrell, Wanling Song, Di Wu, Philipp Heine, Tony Warne, Yang Lee, B. Carpenter, A. Plückthun, C. Tate, M. Sansom, C. Robinson   +14 more
semanticscholar   +1 more source