Results 151 to 160 of about 2,519,690 (191)
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Asymmetric syntheses of pipecolic acid and derivatives
Amino Acids, 1999Results in the field of asymmetric synthesis of pipecolic acid derivatives are reviewed. Three sections describe the asymmetric syntheses of the title compounds (i) from the chiral pool (alpha-amino acids or carbohydrates) (ii) using a chiral auxiliary either derived from terpenes, alpha-amino acids, tartaric acid, an amine or beta-amino alcohols (iii)
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Pipecolic acid induces apoptosis in neuronal cells
Brain Research, 2003Pipecolic acid, a lysine metabolite, is thought to be a factor responsible for hepatic encephalopathy; however, the underlying mechanism is far from understood. Twenty minutes treatment with D-, L-, and DL-pipecolic acid at concentrations ranging from 1 to 100 microM, except for 1 microM L-pipecolic acid, had no inhibitory effect on excitatory ...
Shinji, Matsumoto +6 more
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Conformationally Restricted Nonchiral Pipecolic Acid Analogues
The Journal of Organic Chemistry, 2009Practical syntheses of 2-azabicyclo[3.1.1]heptane-1-carboxylic (2,4-methanopipecolic), 2-azabicyclo[2.2.2]octane-1-carboxylic (2,5-ethanopipecolic), and 9-azabicyclo[3.3.1]nonane-1-carboxylic (2,6-propanopipecolic) acids are reported. The synthetic schemes are short (five, seven, and five steps, respectively) and result in reasonably high yields of the
Dmytro S, Radchenko +3 more
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1971
Publisher Summary This chapter focuses on Pipecolic Acid. A survey of the ninhydrin-positive components of the nonprotein nitrogen fraction of plants revealed several unknowns, one of which, present in the fruit of beans and other legumes, and in lesser quantities in other plants, was subsequently isolated and identified as L(–)- pipecolic acid (I ...
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Publisher Summary This chapter focuses on Pipecolic Acid. A survey of the ninhydrin-positive components of the nonprotein nitrogen fraction of plants revealed several unknowns, one of which, present in the fruit of beans and other legumes, and in lesser quantities in other plants, was subsequently isolated and identified as L(–)- pipecolic acid (I ...
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Archiv der Pharmazie, 1992
AbstractThe Diels‐Alder product 1 is transformed by Noyori reaction and catalytic hydrogenation to 4. Hydrolysis with concomitant decarboxylation of 4 furnishes the trans configuration amino acid 5. Functional group transformation (reduction, lactonization) of 5 provides 7, ring opening affords the pipecolic acid derivative 9.
Claus Herdeis, Wolfram Engel
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AbstractThe Diels‐Alder product 1 is transformed by Noyori reaction and catalytic hydrogenation to 4. Hydrolysis with concomitant decarboxylation of 4 furnishes the trans configuration amino acid 5. Functional group transformation (reduction, lactonization) of 5 provides 7, ring opening affords the pipecolic acid derivative 9.
Claus Herdeis, Wolfram Engel
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Pipecolic acid receptors in rat cerebral cortex
Neurochemical Research, 1986Identification of [14C]pipecolic acid (PA) receptors was attempted in the solubilized membrane fraction from rat cerebral cortex. Specific binding proteins for both PA and muscimol, a potent gamma-aminobutyric acid (GABA) agonist, were detected in the same preparation.
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Metabolism and uptake of -pipecolic acid by brain and heart
Life Sciences, 1981Abstract Metabolism and uptake of L -[1- 14 C]pipecolate was studied in the rat through tail vein injection at low (30 μg/kg) and high (30 mg/kg) doses. No radioactive compound other than L -pipecolate was detected in the brain or heart samples 0.5 to 60 min after injection. The contents of L -pipecolate in the brain dropped rapidly to
A K, Charles, Y F, Chang
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A short enantioselective synthesis of pipecolic acid
Tetrahedron: Asymmetry, 1995Abstract A simple enantioselective route to pipecolic acid is described. The key step involves the Sharpless asymmetric epoxidation of an N-protected aminoheptenol which spontaneously cyclises to a piperidine derivative on deprotection.
Concepción Fernández-García +1 more
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Asymmetric synthesis of pipecolic acid derivatives
Tetrahedron, 1992Abstract Condensation of chiral N-homoallyl β-amino alcohols with glyoxal produces iminium ions which are cyclized with complete stereoselectivity. These substrates, whose reactivity is closely dependent on the substitution pattern of the ethylenic moiety, undergo ene-iminium cyclizations that ultimately lead to homochiral pipecolic acid derivatives.
Claude Agami +3 more
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ChemInform, 1998
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
B. HO, T. M. ZABRISKIE
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AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
B. HO, T. M. ZABRISKIE
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