Results 111 to 120 of about 13,032 (188)

Cytotoxicity and Antimicrobial Activity of GaMF1 Analogs

ChemMedChem, Volume 21, Issue 4, 25 February 2026.
GaMF1 is a reported, highly potent inhibitor of mycobacterial ATP synthase. Structural modification of this scaffold significantly changes biological activity. We present GaMF1 analogues with strong antiparasitic effects, potential antiproliferative properties, and discuss the selectivity limitations of the parent compound and its analogues.
Jan Chasák, Petr Vyvlečka, Ivan Nemec, An Matheeussen, Natascha Van Pelt, Paul Cos, Guy Caljon, Vladimír Kryštof, Lucie Brulíková   +8 more
wiley   +1 more source

An Imidazo[2,1‐b][1,3,4]thiadiazole Derivative Inhibits the Virulence Factor α‐Hemolysin by Blocking the Pullout of Its Stem Domain

ChemMedChem, Volume 21, Issue 4, 25 February 2026.
A high‐throughput cellular screen based on Ca2+ influx in U937 monocytic cells identified thiadiazoles as small‐molecule inhibitors of α‐hemolysin, a key virulence factor of Staphylococcus aureus. The thiadiazole 1 prevents pore formation by a dual mechanism that prevents stem loop unfolding as well as membrane attachment.
Vadim S. Korotkov, Peer Lukat, Raffaella Di Lucrezia, Aditya Shekhar, Carsten Degenhart, Randi Diestel, Ursula Bilitewski, Klaus Dinkel, Wulf Blankenfeldt, Mark Brönstrup   +9 more
wiley   +1 more source

Piperazine [PDF]

The American Journal of the Medical Sciences, 1894
openaire   +1 more source

Bioactivity Profiles of Progressively Ring-Fluorinated Cyclohexyl Motifs in the WKYMVm Peptide as Formylpeptide FPR2 Agonists and in Keto-Piperazines as Antitrypanosome Agents. [PDF]

Chembiochem
He M, Thomson CM, Thompson D, Kuodis V, Smith TK, Dall'Angelo S, O'Hagan D.   +6 more
europepmc   +1 more source

Piperazine Derivatives: A Privileged Scaffold in Modern Synthesis and Medicinal Chemistry. [PDF]

ChemistryOpen
Ten A, Koizhaiganova R, Bissenbay D, Tursynova B, Zhaxibayeva Z, Yu V.   +5 more
europepmc   +1 more source

Structural Exploitation of Cinnarizine Identified Novel Drug-Like Anthelmintic Agents Against <i>Angiostrongylus cantonensis</i>. [PDF]

ACS Infect Dis
Lemes BL, Siegl-Breno MA, Silva-Nunes MK, Lopes FB, Silva AS, Motta NEP, de Moraes J, Fernandes JPS.   +7 more
europepmc   +1 more source

Defining the mechanism of action of the nitrofuranyl piperazine HC2210 against Mycobacterium abscessus. [PDF]

NPJ Antimicrob Resist
Eke IE, Abdalla BJ, Soverina S, Olive AJ, Cicchetti N, Carey AF, Abramovitch RB.   +6 more
europepmc   +1 more source

Novel 1-(2-Aryl-2-adamantyl)piperazine Derivatives Exhibit In Vitro Anticancer Activity Across Various Human Cancer Cell Lines, with Selective Efficacy Against Melanoma. [PDF]

Medicina (Kaunas)
Papapostolou I, Sereti E, Chatira S, Sakellaridis N, Fytas G, Zoidis G, Dimas K.   +6 more
europepmc   +1 more source

Ammonium Zincates as Catalysts for the Microwave-Enhanced Synthesis of Symmetric Piperazines by Regioselective Opening of Aziridines. [PDF]

Chem Asian J
Alberti M, Dariol A, Panza N, Abbiati G, Caselli A.   +4 more
europepmc   +1 more source

Management of Severe Abemaciclib-induced Liver Dysfunction: Feasibility of Switching to Palbociclib. [PDF]

In Vivo
Takada S, Umehara K, Watanabe K.
europepmc   +1 more source