Results 131 to 140 of about 43,723 (349)

EMCDDA trend report for the evaluation of the 2005–12 EU drugs strategy. [PDF]

, 2012
This report has been compiled by the EMCDDA in the first half of 2011 as a supporting document for the external evaluation of the 2005–12 EU drugs strategy and its two 2005–08 and 2009–12 action plans.

core  

In situ monitoring of cell adhesion kinetics using label‐free optical biosensors: Evaluating anticancer potential and selectivity of natural compounds

VIEW, EarlyView.
The limitations of conventional techniques hinder the identification of natural compounds with anticancer potential in terms of speed, throughput, sensitivity, and capability of continuous monitoring of relevant biological effects. Novel label‐free optical biosensors represent new opportunities in the discovery of drug candidates, eliminating these ...
Beatrix Péter, Tim Ausbüttel, Nicolett Kanyo, Péter Joó, Kinga Tóth, Zoltán Szittner, Inna Szekacs, Szilvia Bosze, Gábor M. Kovács, Imre Boldizsár, Robert Horvath   +10 more
wiley   +1 more source

Enantioselective synthesis of gem-disubstituted N-Boc diazaheterocycles via decarboxylative asymmetric allylic alkylation [PDF]

, 2019
An enantioselective synthesis of diverse N4-Boc-protected α,α-disubstituted piperazin-2-ones using the palladium-catalyzed decarboxylative allylic alkylation reaction has been achieved.
Hess, Stephan N., Stoltz, Brian M., Sun, Alexander W.   +2 more
core   +1 more source

Development of a novel risk score reflecting the relative harm potential of synthetic cannabinoids based on prevalence estimates, well‐documented intoxication cases and basic pharmacological data

Addiction, EarlyView.
Abstract Background and aims While the health hazards of synthetic cannabinoid receptor agonists (SCRAs) are often approximated using in vitro pharmacological parameters as surrogate, this approach fails to consider pharmacokinetic and pharmacodynamic complexity.
Michaela J. Sommer, Katharina Elisabeth Grafinger, Maren Hermanns‐Clausen, Volker Auwärter   +3 more
wiley   +1 more source

Trends in fentanyl‐containing drug samples seized by law enforcement agencies across Canada

Addiction, EarlyView.
Abstract Background and aims Canada's drug toxicity crisis has been largely attributed to a volatile fentanyl‐dominated unregulated drug supply with increasing reports of fentanyl detected in combination with benzodiazepines, stimulants and xylazine.
Shaleesa Ledlie, Ria Garg, Pamela Leece, Gillian Kolla, Elaine Hyshka, Mina Tadrous, Tara Gomes   +6 more
wiley   +1 more source

Evaluation of the alpha 2‐adrenoceptor blocking properties of buspirone and ipsapirone in healthy subjects. Relationship with the plasma concentration of the common metabolite 1‐(2‐pyrimidinyl)‐piperazine. [PDF]

, 1995
Ivan Berlin, Sylvie Chalon, Christine Payan, G. Schöllnhammer, F. Cesselin, O Varoquaux, Puech Aj   +6 more
openalex   +1 more source

Mitochondrial Ca2+ overload is a pivotal risk factor for lethal ventricular arrhythmias due to the oxidation of mitochondrial respirasome and energetic failure

British Journal of Pharmacology, EarlyView.
The data that support the findings of this study are available from the corresponding author upon reasonable request. Some data may not be made available because of privacy or ethical restrictions. Background and Purpose Ventricular arrhythmias are a leading cause of death among patients with cardiovascular diseases and are associated with elevated ...
Felipe de Jesús Salazar‐Ramírez, Luis Alberto Luévano‐Martínez, Abraham Méndez‐Fernández, Judith Bernal‐Ramírez, Carolina A. Morales‐Ochoa, Christian Silva‐Platas, Alfredo Cabrera‐Orefice, Ana C. Murrieta, José Luis Velasco‐Bolom, Gricelda Mendiola‐Garza, Flavio Contreras‐Torres, Guillermo Torre‐Amione, Ernesto A. Aiello, Gerardo García‐Rivas   +13 more
wiley   +1 more source

The study on organic nitrates, part V. New derivatives of piperazine potential NO donors [PDF]

, 2002
Lucyna Korzycka
openalex   +1 more source

Spreading depolarization and its influence on epileptiform activity

Epilepsia, EarlyView.
Abstract Spreading depolarization (SD) is a transient disruption of electrographic activity that slowly propagates through the gray matter by chemical contiguity, and it is characterized by a large depolarization of neurons and glial cells. SD, which is associated with massive changes in ion homeostasis, including extreme increases in [K+]o, was shown ...
Maxime Lévesque, Rüdiger Köhling, Massimo Avoli   +2 more
wiley   +1 more source

Synthesis, Dynamic NMR Characterization, and XRD Study of 2,4-Difluorobenzoyl-Substituted Piperazines

Chemistry
Five different 2,4-difluorobenzamide derivatives were synthesized and fully characterized by 1H/13C/19F/2D NMR spectroscopy using DMSO-d6 as solvent and MS.
Martin Köckerling, Constantin Mamat
doaj   +1 more source