Results 141 to 150 of about 43,723 (349)

First Reported Fatalities Associated with the 'Research Chemical' 2-Methoxydiphenidine [PDF]

2-Methoxydiphenidine, i.e. 1-[1-(2-methoxyphenyl)-2-phenylethyl]piperidine, also known as 'MXP' or '2-MeO-diphenidine' (or 2-MXP), has been available as a 'research chemical' since 2013 as a purported alternative to the 'dissociative anesthetics ...
Brandt, SD, Elliott, SP, Kavanagh, PV, Morris, H, Wallach, J   +4 more
core   +1 more source

Aquaporin‐1, aquaporin‐3 and aquaporin‐5 differentially modulate cell biophysical and biomechanical properties, impacting cell stiffness and cell–cell adhesion

The FEBS Journal, EarlyView.
GA text Overexpression of aquaporins AQP1, AQP3, or AQP5 in HEK‐293 T cells induced changes in cell biophysical properties and migration. Atomic force microscopy (AFM)–based force spectroscopy studies demonstrated that AQP1 overexpression increased cell stiffness and cell–cell adhesion, AQP3 augmented cell stiffness but reduced cell–cell adhesion ...
Catarina Pimpão, Filomena A. Carvalho, Inês Vieira da Silva, Andreia Barateiro, Nuno C. Santos, Graça Soveral   +5 more
wiley   +1 more source

Synthesis of Some New 1-[2-(alkylthio-1-benzyl-5-imidazolyl) carbonyl]-4-[3-(isopropylamino)-2-pyridyl] piperazines as Anti-HIV [PDF]

Journal of Sciences, Islamic Republic of Iran, 2004
A few analogues of atevirdine or 1-[(5-methoxyindol-2-yl) carbonyl]-4-[3- (ethylamino)-2-pyridyl] piperazine – an anti-HIV belonging to non-nucleoside reverse transcriptase inhibitors were synthesized and evaluated for anti-HIV activity.
doaj  

Krisanaklan Reduces Intestinal Anion and Fluid Secretion Through Inhibition of Na+/K+‐ATPase and K+ Channel Activity

Annals of the New York Academy of Sciences, EarlyView.
Krisanaklan reduces CFTR‐dependent intestinal chloride and fluid secretion by inhibiting the Na+,K+‐ATPase and K+ channels in epithelial cells. Consequently, this natural, plant‐derived product may limit secretory diarrhea caused by a diverse array of microbial pathogens. However, by dissipating the transmembrane Na+ gradient, Krisanaklan also inhibits
Tessa A. Groeneweg, Erdene Baigal, Anny Leung, Gert‐Jan Kremers, Marcel J. C. Bijvelds   +4 more
wiley   +1 more source

Novel Sulfonium Reagents for the Modular Synthesis of Spiro[2.3]Hexanes and Heteroatom‐Containing Analogues: Synthesis, Application, and Evaluation as Bioisosteres

Angewandte Chemie, Volume 138, Issue 5, 28 January 2026.
Strained spirocyclic spiro[2.3]hexane and its heteroatom‐containing derivatives, including previously underrepresented 5‐oxa‐1‐azaspiro[2.3]hexanes and 1,5‐diazaspiro[2.3]hexanes, were synthesized via a modular approach of insertion of cyclobutane‐, oxetane‐, and azetidine‐containing sulfonium reagents into alkenes, carbonyls and imines.
Philipp Natho, Annarita Vicenti, Fabrizio Mastrolorito, Francesca De Franco, Lee Walsh‐Benn, Marco Colella, Ernesto Mesto, Emanuela Schingaro, Orazio Nicolotti, Antimo Gioiello, Renzo Luisi   +10 more
wiley   +2 more sources

Steroid Hormones Are Potent and Putatively Endogenous Activators of Human Bitter Taste Receptors

Annals of the New York Academy of Sciences, EarlyView.
Human bitter taste receptors are not only involved in sensing tastants within the oral cavity but also play crucial roles in internal tissues of the body. The current report identifies numerous structurally and functionally diverse steroid hormones as activators of the two human bitter taste receptors, TAS2R14 and TAS2R46.
Tatjana Lang, Francesco Ferri, Florian Ziegler, Antonella Di Pizio, Maik Behrens   +4 more
wiley   +1 more source

Alkyl piperidine and piperazine hydroxamic acids as HDAC inhibitors

, 2011
Cristina Rossi, Marina Porcelloni, Piero D’Andrea, Christopher I. Fincham, Alessandro Ettorre, Sandro Mauro, Antonella Squarcia, Mario Bigioni, Massimo Parlani, Federica Nardelli, Monica Binaschi, Carlo Alberto Maggi, Daniela Fattori   +12 more
openalex   +1 more source

Actions of KMUP‐1, a xanthine and piperazine derivative, on voltage‐gated Na⁺ and Ca²⁺‐activated K⁺ currents in GH₃ pituitary tumour cells [PDF]

, 2015
Yi‐Ching Lo, Yu‐Ting Tseng, Chi‐Ming Liu, Bin‐Nan Wu, Sheng‐Nan Wu   +4 more
openalex   +1 more source

Novel piperazine based compounds as potential inhibitors for SARS-CoV-2 Protease Enzyme: Synthesis and molecular docking study

, 2021
Alaa Z. Omar, Tawfik M. Mosa, Samer K. El-sadany, Ezzat A. Hamed, Mohamed A. El‐Atawy   +4 more
openalex   +2 more sources

The Volatile Pentadecane From Bacillus Alleviates Plant Iron Deficiency Through Activating the Reduction‐Based Fe Uptake System

Plant Biotechnology Journal, EarlyView.
ABSTRACT Iron (Fe) is an essential micronutrient for plant growth and development. Rhizosphere microorganisms play crucial roles in plant Fe nutrition, yet the underlying mechanisms remain largely unknown. Here, we assessed the effect of the volatile organic compounds (VOCs) produced by Bacillus velezensis SQR9 on Fe uptake in Arabidopsis, elucidated ...
Taimeng Tan, Lili Tao, Yuling Zhang, Pascale B. Beauregard, Xinli Sun, Youzhi Miao, Nan Zhang, Weibing Xun, Wei Ran, Baolei Jia, Ruifu Zhang, Qirong Shen, Zhihui Xu   +12 more
wiley   +1 more source