Results 11 to 20 of about 13,032 (188)
Stereoselective electrochemical intramolecular imino-pinacol reaction: a straightforward entry to enantiopure piperazines [PDF]
Beilstein Journal of Organic ChemistryThe stereoselective electroreductive intramolecular coupling of chiral diimines of aromatic aldehydes with trans-1,2-diaminocyclohexane for the synthesis of enantiopure tetrasubstituted piperazines has been investigated by an electrochemical approach ...
Margherita Gazzotti +5 more
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Discovery of a novel piperazine derivative, cmp2: a selective TRPC6 activator suitable for treatment of synaptic deficiency in Alzheimer’s disease hippocampal neurons [PDF]
Scientific ReportsAlzheimer disease (AD) is characterized by progressive loss of memory. Synaptic loss is now the best correlate of cognitive dysfunction in patients with Alzheimer’s disease.
Nikita Zernov +5 more
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Molecules, 2022 Piperazine-based dithiocarbamates serve as important scaffolds for numerous pharmacologically active drugs. The current study investigates the design and synthesis of a series of dithiocarbamates with a piperazine unit as well as their biological ...
Freeha Hafeez +8 more
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Experimental study of the pharmacological activity of new azaheterocycles derivatives: A literature review [PDF]
Ķazaķstannyṇ Klinikalyķ Medicinasy, 2022 Diseases associated with the pathology of the cardiovascular system are one of the key causes of death all over the world. In particular, arrhythmia may entail the most severe complications, including unexpected death.
Malika Khaiitova +4 more
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Recent Advances in the Synthesis of Piperazines: Focus on C–H Functionalization
Organics, 2021 Piperazine ranks as the third most common nitrogen heterocycle in drug discovery, and it is the key component of several blockbuster drugs, such as Imatinib (also marketed as Gleevec) or Sildenafil, sold as Viagra.
Carolina Durand, Michal Szostak
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New psychoactive substances and the risks of consumption in children and adolescents [PDF]
Romanian Journal of Pediatrics, 2019 According to the definition established by the European Monitoring Center for Drugs and Drug Addiction (EMCDDA) a “new psychoactive substance is considered any narcotic or psychotropic substance in pure form or in preparations, which is not controlled by
Viorela Nitescu
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Synthesis of Chromeno[3,4-b]piperazines by an Enol-Ugi/Reduction/Cyclization Sequence
Molecules, 2021 Keto piperazines and aminocoumarins are privileged building blocks for the construction of geometrically constrained peptides and therefore valuable structures in drug discovery.
Ana Bornadiego +2 more
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Acta Crystallographica Section E: Crystallographic Communications, 2020 The structures are reported for five salts formed by reactions between N-(4-fluorophenyl)piperazine and aromatic acids. In 4-(4-fluorophenyl)piperazin-1-ium 2-fluorobenzoate monohydrate, C10H14FN2+·C7H4FO2−·H2O, (I), the components are linked by a ...
Chayanna Harish Chinthal +4 more
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Acta Crystallographica Section E: Crystallographic Communications, 2020 Fifteen 4-(2-methoxyphenyl)piperazin-1-ium salts containing organic anions have been prepared and structurally characterized. In the isostructural 4-chlorobenzoate and 4-bromobenzoate salts, C11H17N2O+·C7H4ClO2− (I) and C11H17N2O+·C7H4BrO2− (II), and the
Chayanna Harish Chinthal +5 more
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Acta Crystallographica Section E: Crystallographic Communications, 2020 Crystal structures are reported for N-(4-methoxyphenyl)piperazine (MeOPP), (I), and for its 3,5-dinitrobenzoate, 2,4,6-trinitrophenolate (picrate) and 4-aminobenzoate salts, (II)–(IV), the last of which crystallizes as a monohydrate. In MeOPP, C11H16N2O,
Haruvegowda Kiran Kumar +4 more
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