Results 61 to 70 of about 43,723 (349)

Stereospecific Ring Opening and Cycloisomerization of Aziridines with Propargylamines: Synthesis of Functionalized Piperazines and Tetrahydropyrazines.

Organic Letters, 2018
Stereospecific Cu-catalyzed nucleophilic ring opening of N-sulfonylaziridines with propargylamines and subsequent hydroamination afford piperazines, which leads to double-bond isomerization to furnish tetrahydropyrazines.
Bijay Ketan Das, Sourav Pradhan, T. Punniyamurthy   +2 more
semanticscholar   +1 more source

A 3D Biofabricated Disease Model Mimicking the Brain Extracellular Matrix Suitable to Characterize Intrinsic Neuronal Network Alterations in the Presence of a Breast Tumor Disseminated to the Brain

Advanced Functional Materials, EarlyView.
A 3D disease model is developed using customized hyaluronic‐acid‐based hydrogels supplemented with extracellular matrix (ECM) proteins resembling brain ECM properties. Neurons, astrocytes, and tumor cells are used to mimic the native brain surrounding.
Esra Türker, Mateo S. Andrade Mier, Jessica Faber, Mike Friedrich, Zan Lamberger, Jeannette Weigelt, Christian Stigloher, Nicoletta Murenu, Natascha Schaefer, Jörg Tessmar, Gregor Lang, Silvia Budday, Katrin G. Heinze, Antje Appelt‐Menzel, Pamela L. Strissel, Reiner Strick, Carmen Villmann   +16 more
wiley   +1 more source

Synthesis of novel antibacterial and antifungal dithiocarbamate-containing piperazine derivatives via re-engineering multicomponent approach

Heliyon, 2022
A metal-free multicomponent synthetic route for the diverse preparation of dithiocarbamate-containing piperazine derivatives was developed through the C–N bond cleavage of DABCO ring.
Azim Ziyaei Halimehjani, Faezeh Dehghan, Vida Tafakori, Elaheh Amini, Seyyed Emad Hooshmand, Yazdanbkhsh Lotfi Nosood   +5 more
doaj   +1 more source

Microcrystalline testing used in combination with Raman micro-spectroscopy for absolute identification of novel psychoactive substances [PDF]

, 2016
Two new psychoactive substances, namely 4-methylmethcathinone (mephedrone) and 5,6-methylenedioxy-2-aminoindane (MDAI) were analysed with a novel combination of microcrystalline tests followed by Raman micro-spectroscopy to facilitate their absolute ...
Aakeröy, Abdel-Hay, Al-Hossaini, Assi, Assi, Awad, Baron, Belal, Choodum, Christie, Cumba, Cuypers, Davis, Donahue, Elie, Elie, Elie, Emanuel, Fulton, Gallagher, Gibbons, Isaacs, Jones, Lobo Vicente, Mabbott, Mabbott, Mabbott, Maher, Nic Daeid, Nichols, O'Neal, Power, Smith, Smith, Smith, Socrates, Steiner, Tan, Tsumura, Vishweshwar, White, Wood, Wood, Wood, Wood, Zuway   +45 more
core   +3 more sources

Bioinspired Polypeptide Dendrimer‐Modified Thin‐Film Composite Membranes for Selective Lithium‐Magnesium Separation with DFT Insights

Advanced Functional Materials, EarlyView.
We fabricated a biomimetic dendrimer‐modified thin‐film nanocomposite membrane with a coordination‐assisted ion‐selective interface. pH‐responsive polypeptide sites preferentially bind Mg2+ and promote Li+ permeation, as predicted by density functional theory calculations of metal‐ligand interactions.
Mehrasa Yassari, Seyedeh Fatemeh Seyedpour, Bamlak Setegne, Amir Aghaei, Behzad Ahvazi, Mostafa Dadashi Firouzjaei, Mark Elliott, Mohtada Sadrzadeh   +7 more
wiley   +1 more source

Deaths of individuals aged 16-24 years in the UK after using mephedrone [PDF]

, 2015
Objective: Mephedrone is a stimulant drug chemically related to amphetamine, with effects similar to those of amphetamine and cocaine. This study aims to analyse fatalities following ingestion of mephedrone in the UK amongst 16-24 year olds in 2009-13 ...
Advisory Council on the Misuse of Drugs (ACMD), Advisory Council on the Misuse of Drugs (ACMD), Carhart-Harris, Corkery, Cosbey, Cozzi, Dargan, De Letter, Dickson, Durham, Dyer, Home Office, James, Kalix, Kalix, López-Arnau, Maskell, Measham, Meltzer, Morris, Newcombe, Schifano, Schifano, Schifano, Schifano, Schifano, Simmler, Torrance, Tsitsika, Winstock, Winstock, Winstock, Wood, Wood, Wood, Wood, Yamamoto   +36 more
core   +1 more source

Fluorescent Polymeric Nanofibers as Ratiometric Multiplexed Skin Sensors of pH and Oxygen

Advanced Healthcare Materials, EarlyView.
Fluorescent polymeric nanofibers and nanorods are produced as ratiometric sensors of two important physiological parameters: pH and oxygen. They operate by dual Forster resonance energy transfer from large number of energy donor dyes to limited number of two distinct energy acceptors, enabling simultaneous sensing of pH and oxygen.
Rémi Pelletier, Anila Hoskere Ashoka, Andrey S. Klymchenko   +2 more
wiley   +1 more source

Radiation mitigation of the intestinal acute radiation injury in mice by 1-[(4-nitrophenyl)sulfonyl]-4-phenylpiperazine. [PDF]

, 2020
The objective of the study was to identify the mechanism of action for a radiation mitigator of the gastrointestinal (GI) acute radiation syndrome (ARS), identified in an unbiased high-throughput screen.
Alli, Claudia, Bhat, Kruttika, Cheng, Fei, Duhachek-Muggy, Sara, Eghbali, Mansoureh, He, Ling, Medina, Paul, Muthukrishnan, Sree Deepthi, Pajonk, Frank, Ruffenach, Gregoire, Saki, Mohammad, Vlashi, Erina   +11 more
core   +1 more source

NMR-based investigations of acyl-functionalized piperazines concerning their conformational behavior in solution

RSC Advances, 2018
Selected N-benzoylated piperazine compounds were synthesized to study their conformational behavior using temperature-dependent 1H NMR spectroscopy.
R. Wodtke, Janine Steinberg, M. Köckerling, R. Löser, C. Mamat   +4 more
semanticscholar   +1 more source

Dual‐Functional Polyphosphoesters for Gene Delivery: Synergistic Effects of Guanidinium and Hydrophobic Side Chains in Degradable Polymers

Advanced Healthcare Materials, EarlyView.
This study presents guanidinium‐ and indole‐functionalized polyphosphoesters as degradable, non‐viral gene delivery vectors. Through precise tuning of charge density and hydrophobicity, these polymers form stable polyplexes with low toxicity. Remarkably, minor structural changes yield up to 200‐fold differences in transfection efficiency, highlighting ...
Markus Kötzsche, Andreas Dzierza, Jan Egger, Timo Rheinberger, Christin Weilandt, Frederik R. Wurm, Ivo Nischang, Dagmar Fischer, Kalina Peneva   +8 more
wiley   +1 more source