Results 1 to 10 of about 84,342 (322)
Synthesis of a novel analogue of DPP-4 inhibitor Alogliptin: Introduction of a spirocyclic moiety on the piperidine ring [PDF]
Beilstein Journal of Organic Chemistry, 2010 We report the synthesis of a novel analogue of Alogliptin via condensation of two key intermediates one of which is an aminopiperidine derivative bearing a spirocyclic ring on the piperidine moiety.
Arumugam Kodimuthali +2 more
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PEG-embedded KBr3: A recyclable catalyst for multicomponent coupling reaction for the efficient synthesis of functionalized piperidines [PDF]
Beilstein Journal of Organic Chemistry, 2011 PEG-embedded potassium tribromide ([K+PEG]Br3−) was found to be an efficient and recyclable catalyst for the synthesis of functionalized piperidines in high yields in a one step, three component coupling between aldehyde, amine and β-keto ester.
Sanny Verma, Suman L. Jain, Bir Sain
doaj +2 more sources
Ammonium piperidine-1-carbodithioate [PDF]
Acta Crystallographica Section E Structure Reports Online, 2011 The title compound, NH(4) (+)·C(6)H(10)NS(2) (-), is composed of an ammonium cation and a piperidine-1-carbodithio-ate anion which exhibits positional disorder. The atoms of the ring have a structural disorder and they are divided into two sites, with occupancy factors of 0.584 and 0.426..
Ana C. Mafud, Maria T. P. Gambardella
openaire +5 more sources
GC-MS analysis of the active compound in ethanol extracts of white pepper (Piper nigrum l.) and pharmacological effects [PDF]
Cellular, Molecular and Biomedical Reports, 2022 Pepper (Piper nigrum L.) has been utilized since antiquity and is considered the king of spices due to its wide use. This study aims to analyze the active compounds of white pepper through GC-MS and their pharmacological effects.
I Nyoman Arsana +4 more
doaj +1 more source
Журнал органічної та фармацевтичної хімії, 2021 Aim. To develop a convenient synthetic approach for the preparation of multigram amounts of 4-(trifluoromethoxy)-piperidine and 4-(trifluoromethoxymethyl)piperidine – promising building blocks for medicinal chemistry. Results and discussion.
Ivan G. Logvinenko +2 more
doaj +1 more source
Application of Chiral Piperidine Scaffolds in Drug Design
Pharmaceutical Fronts, 2023 Chiral piperidine scaffolds are prevalent as the common cores of a large number of active pharmaceuticals in medical chemistry. This review outlined the diversity of chiral piperidine scaffolds in recently approved drugs, and also covers the scaffolds in
Qiu-Shi Chen, Jian-Qi Li, Qing-Wei Zhang
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μ-opioid/D2 dopamine receptor pharmacophore containing ligands: Synthesis and pharmacological evaluation [PDF]
Journal of the Serbian Chemical Society, 2020 Herein, the synthesis and pharmacological evaluation of 13 novel compounds, designed as potential heterobivalent ligands for μ-opioid receptor (MOR) and dopamine D2 receptors (D2DAR), are reported. The compounds consisted of anilido piperidine and N-aryl
Jevtić Ivana I. +6 more
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Molecules, 2021 Alzheimer’s disease (AD), a progressive neurodegenerative disorder, characterized by central cognitive dysfunction, memory loss, and intellectual decline poses a major public health problem affecting millions of people around the globe.
Rubina Munir +8 more
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Piperidine nucleus in the field of drug discovery
Future Journal of Pharmaceutical Sciences, 2021 Background Piperidine is an essential heterocyclic system and a pivotal cornerstone in the production of drugs. Piperidine byproducts showed several important pharmacophoric features and are being utilized in different therapeutic applications. Main text
Mennatallah Mahmoud Abdelshaheed +3 more
doaj +1 more source
Molecules, 2023 Venous thromboembolism is a serious problem because it significantly increases the risk of developing vascular complications in elderly patients with obesity or immobilization, cancer, and many other diseases.
Victor P. Krasnov +10 more
doaj +1 more source