Results 1 to 10 of about 37,707 (289)
Журнал органічної та фармацевтичної хімії, 2021 Aim. To develop a convenient synthetic approach for the preparation of multigram amounts of 4-(trifluoromethoxy)-piperidine and 4-(trifluoromethoxymethyl)piperidine – promising building blocks for medicinal chemistry. Results and discussion.
Ivan G. Logvinenko +2 more
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Synthesis, docking, pharmacokinetic prediction, and acetylcholinesterase inhibitory evaluation of N-(2-(piperidine-1-yl)ethyl)benzamide derivatives as potential anti-Alzheimer agents [PDF]
Research in Pharmaceutical SciencesBackground and purpose: Alzheimer’s disease is the most common form of dementia and the sixth most common cause of death in the US according to the Alzheimer’s Association.
Ahmad Mohammadi-Farani +3 more
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GC-MS analysis of the active compound in ethanol extracts of white pepper (Piper nigrum l.) and pharmacological effects [PDF]
Cellular, Molecular and Biomedical Reports, 2022 Pepper (Piper nigrum L.) has been utilized since antiquity and is considered the king of spices due to its wide use. This study aims to analyze the active compounds of white pepper through GC-MS and their pharmacological effects.
I Nyoman Arsana +4 more
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Application of Chiral Piperidine Scaffolds in Drug Design
Pharmaceutical Fronts, 2023 Chiral piperidine scaffolds are prevalent as the common cores of a large number of active pharmaceuticals in medical chemistry. This review outlined the diversity of chiral piperidine scaffolds in recently approved drugs, and also covers the scaffolds in
Qiu-Shi Chen, Jian-Qi Li, Qing-Wei Zhang
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μ-opioid/D2 dopamine receptor pharmacophore containing ligands: Synthesis and pharmacological evaluation [PDF]
Journal of the Serbian Chemical Society, 2020 Herein, the synthesis and pharmacological evaluation of 13 novel compounds, designed as potential heterobivalent ligands for μ-opioid receptor (MOR) and dopamine D2 receptors (D2DAR), are reported. The compounds consisted of anilido piperidine and N-aryl
Jevtić Ivana I. +6 more
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Piperidine nucleus in the field of drug discovery
Future Journal of Pharmaceutical Sciences, 2021 Background Piperidine is an essential heterocyclic system and a pivotal cornerstone in the production of drugs. Piperidine byproducts showed several important pharmacophoric features and are being utilized in different therapeutic applications. Main text
Mennatallah Mahmoud Abdelshaheed +3 more
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Total Synthesis of (–)-Anaferine: A Further Ramification in a Diversity-Oriented Approach
Molecules, 2020 The piperidine ring is a widespread motif in several natural bioactive alkaloids of both vegetal and marine origin. In the last years, a diversity-oriented synthetic (DOS) approach, aimed at the generation of a library of piperidine-based derivatives ...
Elisa Bonandi +3 more
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Molecules, 2023 Venous thromboembolism is a serious problem because it significantly increases the risk of developing vascular complications in elderly patients with obesity or immobilization, cancer, and many other diseases.
Victor P. Krasnov +10 more
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Frontiers in Chemistry, 2020 The nitro-Mannich (aza-Henry) reaction, in which a nitroalkane and an imine react to form a β-nitroamine, is a versatile tool for target-oriented synthesis. Although the first stereoselective reaction was developed only 20 years ago, and enantioselective
Ana Maria Faisca Phillips +2 more
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Hydrogen-bonded aggregates in the mixtures of piperidine with water: thermodynamic, SANS and theoretical studies [PDF]
, 2022 Structures resembling semiclathrates probably arise in liquid aqueous solutions of piperidine at the amine mole fraction below 0.03. With the increasing concentration, the structures gradually decay, but the 1:1 complexes of piperidine with water remain linked one to another through the O-H...O bonds between the hydration water molecules.
arxiv +1 more source