Results 91 to 100 of about 37,707 (289)

Engineering Bodipy‐Based Metal–Organic Frameworks for Efficient Full‐Spectrum Photocatalysis in Amide Synthesis

Angewandte Chemie, EarlyView.
Three highly stable bodipy‐based metal–organic frameworks (BMOFs) were synthesized by treating dicarboxyl‐functionalized bodipy ligands with Zr‐oxo clusters. Featuring the distinct bodipy scaffold in the framework, these BMOFs displayed high reactivity in heterogenous photocatalytic C─H bond activation of N,N‐dimethylanilines to access amides under ...
Binhui Liu, Xu Chen, Yuhao Yang, Mohammad Reza Alizadeh Kiapi, Dhruv Menon, Qianyi Zhao, Guozan Yuan, Luke L. Keenan, David Fairen‐Jimenez, Qingchun Xia   +9 more
wiley   +2 more sources

Synthesis of (‐)‐8a epi‐Lentiginosine via Tsuji‐Trost Reaction of d‐Glucose‐Derived Allylic Alcohols and Crystal Structure Analysis

Asian Journal of Organic Chemistry, Accepted Article.
An indolizidine alkaloid, (‐)‐8a‐epi‐lentiginosine was synthesized from d‐glucose using the Pd‐BiPhePhos catalyzed intramolecular Tsuji‐Trost reaction of non‐derivatized allylic alcohol as a key construction of the hydroxylated pyrrolidine ring to give the desired product in good yield and high diasterespecificity stereospecificity (dr = 97:3).
Sunisa Akkarasamiyo, Patchreenart Saparpakorn, Andreas Orthaber, Joseph Samec   +3 more
wiley   +1 more source

Desulfurizative Fluorination of N‐CF3 Thioformamides for the Efficient Synthesis of N(CF3)(CF2H) Amines with Enhanced Stability

Angewandte Chemie, EarlyView.
We present the first general synthetic strategy for accessing N(CF3)(CF2H) amines, which display a 2000‐fold increase in stability over N‐CF3 amines. The compounds are synthesized through a desulfurization–fluorination of N‐CF3 thioformamides. Abstract With poor metabolic stability being a major cause of failure in drug development, there is a pressing
Gina Wycich, Jaime Ponce‐de‐León, Linhao Liu, Franziska Schoenebeck   +3 more
wiley   +2 more sources

In vivo toxic and lethal cardiorespiratory effects of a synthetic quaternary ammonium salt derivative of haloperidol in mice

Animal Models and Experimental Medicine, EarlyView.
Hematoxylin–eosin (H&E) stains of the heart, liver, lung, and kidney show acute toxicity. Abstract Background To investigate the toxicity of N‐n‐butyl haloperidol iodide (F2), a quaternary ammonium salt derivative of haloperidol, in mice for potential therapeutic purposes. Methods The acute median lethal dose (LD50) of F2 was determined using the Bliss
Jilin Liao, Binger Lu, Jinhua Yang, Xiaowan Wang, Shuxian Li, Hongbo Fu, Fenfei Gao   +6 more
wiley   +1 more source

r-2,c-6-Diphenylpiperidine

Acta Crystallographica Section E, 2013
In the title compound, C17H19N, the piperidine ring adopts a chair conformation. The phenyl rings substituted at the 2- and 6-positions of the piperidine ring subtend dihedral angles of 81.04 (7) and 81.10 (7)° with the best plane of the
V. Maheshwaran, S. Abdul Basheer, A. Akila, S. Ponnuswamy, M. N. Ponnuswamy   +4 more
doaj   +1 more source

3-Nitroso-2,4,6,8-tetraphenyl-3,7-diazabicyclo[3.3.1]nonan-9-one

Acta Crystallographica Section E, 2011
In the title compound, C31H27N3O2, the two piperidine rings fused to each other each adopt a slightly distorted chair conformation. The phenyl rings on the N-unsubstituted piperidine ring occupy an equatorial position, while those on the N-nitroso ...
Sampath Natarajan, Rita Mathews
doaj   +1 more source

1-Dichloroacetyl-t-3-isopropyl-r-2,c-6-diphenylpiperidin-4-one

Acta Crystallographica Section E, 2013
In the title compound, C22H23Cl2NO2, the piperidine ring adopts a twist-boat conformation. The phenyl rings substituted at the 2- and 6-positions of the piperidine ring subtend dihedral angles of 60.6 (2) and 84.2 (1)°, respectively ...
M. N. Ponnuswamy, S. Ponnuswamy, R. Mini, R. Kayalvizhi, P. Sugumar   +4 more
doaj   +1 more source

Crystal structures of two chiral piperidine derivatives: 1-[(1R)-2-hydroxy-1-phenylethyl]piperidin-4-one and 8-[(1S)-1-phenylethyl]-1,4-dioxa-8-azaspiro[4.5]decane-7-thione

Acta Crystallographica Section E: Crystallographic Communications, 2015
The crystal structures of the two title piperidine derivatives show different conformations for the six-membered heterocycle. The N-substituted 4-piperidinone 1-[(1R)-2-hydroxy-1-phenylethyl]piperidin-4-one, C13H17NO2, (I), has a chair conformation ...
Nancy Romero, Sylvain Bernès, Luis F. Roa, Joel L. Terán, Dino Gnecco   +4 more
doaj   +1 more source

Basizität im angeregten Zustand verändert die Selektivität der aromatischen Deuterierung: Anwendung auf die Late‐Stage Markierung von Pharmazeutika

Angewandte Chemie, EarlyView.
Wir präsentieren eine metallfreie Methode für die Deuteriummarkierung von Aromaten in deuteriertem HFIP. Dieser Ansatz nutzt die erhöhte Basizität von Aromaten im angeregten Zustand, um den selektiven Wasserstoffisotopenaustausch an schwer zugänglichen Positionen zu ermöglichen.
Eva Rivera‐Chao, Javier Corpas, Giovanni Lonardi, Volker Derdau, Alessandro Ruffoni, Daniele Leonori   +5 more
wiley   +1 more source

(3-Hydroxypiperidin-1-yl)(4-methylphenyl)methanone

IUCrData, 2017
In the title molecule, C13H17NO2, the piperidine ring assumes a chair conformation. The dihedral angle between the mean plane of the piperidine ring and the benzene ring is 45.49 (1)°.
S. Gomathi, D. Reuben Jonathan, U. Mohamooda Sumaya, E. R. A. Dravida Thendral, G. Usha   +4 more
doaj   +1 more source