Results 121 to 130 of about 37,707 (289)

Aberrant glycosylation of IgG in children with active lupus nephritis alters podocyte metabolism and causes podocyte injury

open access: yesArthritis &Rheumatology, Accepted Article.
Background Podocytes are integral to the maintenance of the glomerular filtration barrier. Their injury results in proteinuria and disease progression in lupus nephritis (LN). Aberrant IgG glycosylation drives podocyte injury in LN and leads to cytoskeletal rearrangement, motility changes and decreased nephrin production.
Rhea Bhargava   +9 more
wiley   +1 more source

Advances in Metal‐Free Transamidation: A Sustainable Approach to Amide Bond Formation

open access: yesChemistry – An Asian Journal, EarlyView.
This review highlights the recent developments of transamidation reactions under metal‐free reaction conditions. Various amines including weak nucleophilic amines such as aromatic amines have been used to achieve the transamidation reactions under mild and relatively green reaction conditions. Abstract The amide functionalities are a crucial functional
Niharan Sivaraj   +2 more
wiley   +1 more source

Photoswitchable, Water‐Soluble Bisazobenzene Cross‐Linkers with Enhanced Properties for Biological Applications

open access: yesChemPhotoChem, Volume 6, Issue 12, December 2022., 2022
Photoswitchable cross‐linkers have the ability to connect two residues on a biomolecule, thereby causing large changes in the structure and function of the target upon irradiation. The design, synthesis and purification of cross‐linkers with large end‐to‐end distances remains challenging, especially for applications in chemical biology.
Jana Volarić   +3 more
wiley   +1 more source

Trifluoroacetyl‐Substituted D–π–A Fluorophores: Design Strategies for Strong Solvatochromism and Giga Stokes Shifts

open access: yesChemistry – An Asian Journal, EarlyView.
Trifluoroacetyl‐substituted D–π–A fluorophore, featuring relatively extended and planar conjugated structure with piperidyl donor and trifluoroacetyl acceptor, demonstrated strong solvatochromism and giga Stokes shifts. This unique and strong acceptor has possibilities to achieve the design of fluorophore for various application, represented by ...
Alto Hori, Gen‐ichi Konishi
wiley   +1 more source

Integrating Affinity Chromatography in the Platform Process for Adenovirus Purification

open access: yesBiotechnology and Bioengineering, EarlyView.
Peptide‐functionalized affinity resins with high adenovirus binding capacity, recovery, and contaminant removal afford excellent productivity, and reduced impurities in a three‐step purification process. ABSTRACT Adenoviral vectors (AdVs) are gaining prominence in cancer therapy and vaccine development, posing the need for a modern AdV manufacturing ...
Yuxuan Wu   +7 more
wiley   +1 more source

Review on the o‐Aminoaniline Moiety in Peptide and Protein Chemistry

open access: yesChemBioChem, EarlyView.
The ability to prepare functional peptides and protein molecules is essential to understand fundamental biological processes and develop novel therapeutics for numerous diseases. In this review, Hong et al. document the development of o‐aminoaniline derivatives for chemical protein synthesis, peptide C‐terminus diversification, and cyclic peptide ...
Ziyong Z. Hong
wiley   +1 more source

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