Results 181 to 190 of about 76,241 (267)

Cationic Poly(2‐oxazoline)s

Macromolecular Chemistry and Physics, Volume 227, Issue 5, 13 March 2026.
Cationic poly(2‐oxazoline)s (POx) have emerged as versatile materials for different biomedical applications. The combination of the pseudo‐peptidic polymer backbone and the amine‐derived cationic motifs results in well‐tolerated polymers with potential benefits for drug and gene delivery as well as antimicrobial development.
Meike N. Leiske
wiley   +1 more source

Regio- and Stereocontrolled-Synthesis of a Heterocycle Fragment Collection Using Palladium Catalyzed C-H Arylation. [PDF]

Chemistry
Piticari AS, Antermite D, Linkhorn HJ, Larionova NA, Webster MP, Bull JA.   +5 more
europepmc   +1 more source

The NLRP3 Inflammasome: Mechanisms of Activation, Regulation, and Therapeutic Opportunities

MedComm, Volume 7, Issue 3, March 2026.
Diverse diseases converge on NLRP3. We depict a discovery‐to‐clinic track: high‐throughput/phenotypic screens, structure‐guided design, and modality innovation (allosteric inhibitors, interface blockers, degraders) deliver third‐generation, disease‐tailored NLRP3 control.
Chan Zou, Shilong Jiang, Hui Li, Kai Zhao, Dongshen Cao, Guoping Yang   +5 more
wiley   +1 more source

Oxidative DNA damage induced by 3,4-diOH-TAM, a tamoxifen metabolite, in relation to endometrial carcinogenesis. [PDF]

Sci Rep
Mori Y, Midorikawa K, Oikawa S, Fukuhara K, Kawanishi S, Murata M.   +5 more
europepmc   +1 more source

Residual Chemical Shift Anisotropies in the Structure Determination of Small Molecules

Magnetic Resonance in Chemistry, Volume 64, Issue 3, Page 286-311, March 2026.
Plasma neutrophil elastase(ELANE) was markedly elevated in patients with alcohol use disorder, indicating a dysregulated protease‐antiprotease inflammatory balance characterised by decreased SERPINA3. ELANE showed excellent diagnostic specificity(AUC = 0.8683), supporting its potential utility as a neuroinflammatory biomarker for AUD.
Nilamoni Nath, Juan Carlos Fuentes Monteverde, Swaraj Pathak, Christian Griesinger   +3 more
wiley   +1 more source

Oxindole based sulfonyl derivatives synthesized as potent inhibitors of alpha amylase and alpha glucosidase along with their molecular docking study. [PDF]

Sci Rep
Taha M, Alomari M, Udin N, Rahim F, Uddin I, Imran S, Khan KM, Shah SAA, Shehzad A.   +8 more
europepmc   +1 more source

Untargeted Metabolomics Reveals Organ‐Specific and Extraction‐Dependent Metabolite Profiles in Endemic Tajik Species Ferula violacea Korovin

Plant Direct, Volume 10, Issue 3, March 2026.
ABSTRACT Ferula violacea Korovin, an endemic Tajikistani plant with purported medicinal properties, remains understudied. This study employs untargeted metabolomics to characterize the metabolite profiles of ethanol extracts and juices from F. violacea roots and seeds.
Sylhiya Mavlonazarova, Kenneth Acosta, Rinat Abzalimov, Saidbeg Satorov, Vyacheslav Dushenkov   +4 more
wiley   +1 more source

Development of a Late-Stage Functionalization Strategy to Access Diverse 3,5-Disubstituted 1,2,4-Thiadiazoles. [PDF]

J Org Chem
Dobria A, Petros ZA, Mickel P, Aldrich LN.   +3 more
europepmc   +1 more source

Turn‐Induction in Peptides Incorporating Novel Cyrene‐Derived α,α‐Disubstituted Amino Acid

Journal of Peptide Science, Volume 32, Issue 3, March 2026.
Novel chiral cyrene‐derived Cyr residues were incorporated into peptides. The α,α‐disubstituted amino acid residue was introduced using the Ugi reaction. X‐ray crystallographic analysis of R‐ and S‐Cyr residues indicated preference to adopt left‐ and right‐handed α‐helical conformations, respectively.
Kajumee Bora Bhowal, Raphael Hitti, William D. Lubell   +2 more
wiley   +1 more source

N-H/P-H bond activation of ammonia, amines and phosphines at a transient borylene. [PDF]

Chem Sci
Weber M, Kar S, Joos P, Dewhurst RD, Braunschweig H.   +4 more
europepmc   +1 more source