Results 211 to 220 of about 84,342 (322)

New .kappa.-receptor agonists based upon a 2-[(alkylamino)methyl]piperidine nucleus

, 1992
D. I. C. SCOPES, D. Neil Hayes, David E. Bays, David Belton, John Brain, Dearg S. Brown, Duncan B. Judd, Andrew B. McElroy, Clive A. Meerholz   +8 more
openalex   +1 more source

Conformational dynamics in insulin receptor kinase reveal a type III allosteric pocket

Protein Science, Volume 35, Issue 2, February 2026.
Abstract Allosteric modulation is a promising strategy for selective kinase inhibition, yet structural insights into allosteric pockets remain limited across the human kinome. In this work, we present comprehensive characterization of a type III allosteric pocket in the insulin receptor kinase (IRK), integrating structural, conformational, and ...
Jyoti Verma, Harish Vashisth
wiley   +1 more source

Computational Chemistry Advances in the Development of PARP1 Inhibitors for Breast Cancer Therapy. [PDF]

Pharmaceuticals (Basel)
Twala C, Govender P, Govender K.
europepmc   +1 more source

Design, Synthesis,and Biological Activity Evaluationof Flavonol Derivatives Containing Piperazine and Piperidine Thiourea

Yuhong Wang (85102), Hong Fu (37557), Haotao Pu (19864748), Hongqian Zou (20111801), Han Yang (704814), Xiaoyan Pan (2178640), Xianghui Ruan (4216966), Wei Xue (219900)   +7 more
openalex   +1 more source

Expansion of Structure−Activity Studies of Piperidine Analogues of 1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine (GBR 12935) Compounds by Altering Substitutions in the N-Benzyl Moiety and Behavioral Pharmacology of Selected Molecules

, 2001
Aloke K. Dutta, Matthew C. Davis, Xiang‐Shu Fei, Patrick M. Beardsley, Charles D. Cook, Maarten E. A. Reith   +5 more
openalex   +1 more source

A natural barrier: tick‐repellent potential of a spruce‐derived volatile blend against Hyalomma excavatum and Ixodes ricinus

Pest Management Science, Volume 82, Issue 2, Page 1481-1491, February 2026.
Both active and passive questing ticks, Hyalomma excavatum and Ixodes ricinus, were assessed for behavioural responses to two novel plant‐derived repellent volatile organic compound blends. Both tick species were repelled by the products, and both novo blends were significantly more repellent than currently available commercial products.
Martyn J. Wood, Sare I. Yavaşoğlu, James C. Bull, Serkan Bakırcı, Kanagasooriyam Kanagachandran, Tariq M. Butt   +5 more
wiley   +1 more source

Isoniazid-Derived Hydrazones Featuring Piperazine/Piperidine Rings: Design, Synthesis, and Investigation of Antitubercular Activity. [PDF]

Biomolecules
Özcan E, Vagolu SK, Tamhaev R, Lherbet C, Mourey L, Tønjum T, Gündüz MG, Doğan ŞD.   +7 more
europepmc   +1 more source

Molecular docking, Biological Evaluation of a Co (II) Complex derivative of N⁵, N⁵-di(piperidine-2-carbonyl)-[2,2'-bipyridine]-5,5'-dicarboxamide Ligand [PDF]

Nahal Hadi, Furqan K. K. AL-Fatlawi, Hussein Abbas Khursheed, Ali Jawad   +3 more
openalex   +1 more source

Discovery of Fragment-Based Inhibitors of SARS-CoV-2 PL^Pro. [PDF]

J Med Chem
Wei Q, Taylor AJ, Barmade MA, Teuscher KB, Chowdhury S, Apakama C, Anderson-Daniels J, Yongqing Z, Schultz DC, Rietz TA, South TM, Crow MM, Zhao B, Amporndanai K, Sensintaffar JL, Phan J, Cherry S, Denison M, Lee T, Fesik SW.   +19 more
europepmc   +1 more source

Design, synthesis, and structure–activity relationships of novel spiro-piperidines as acetyl-CoA carboxylase inhibitors

, 2012
Makoto Kamata, Takashi Yamashita, Asato Kina, Masaaki Funata, Atsushi Mizukami, Masako Sasaki, Akiyoshi Tani, Miyuki Funami, Nobuyuki Amano, K. Fukatsu   +9 more
openalex   +1 more source