Results 251 to 260 of about 47,089 (385)

Facile and Practical Synthesis of Substituted Piperidine‐2,6‐Diones Under Transition‐Metal Free Condition

open access: yesChemistryOpen, EarlyView.
KOtBu‐promoted facile and practical synthesis of various substituted piperidine‐2,6‐diones between methyl acetates and acrylamides via a Michael addition/intramolecular imidation cascade sequence has been disclosed. And reaction scale‐up, further transformation of representative products, and preparation of bioactive molecules (e. g.
Yue‐Hua Liu   +7 more
wiley   +1 more source

“Molecular Docking and Dynamic Studies of Amide Derivatives from Cinnamic Acid with Potential Anti‐Dengue Virus Activity”

open access: yesChemistryOpen, EarlyView.
A library of easily synthesizable CAPE analogs was screened in silico against the dengue virus envelope protein. Compound LQM778 showed stable binding and promising inhibitory potential. This study highlights LQM778 as a candidate for future in vitro validation and structural optimization toward accessible antiviral agents against dengue.
Luis Alfonso Cárdenas‐Granados   +9 more
wiley   +1 more source

Novel Potent and Selective Dopamine D4 Receptor Piperidine Antagonists as Potential Alternatives for the Treatment of Glioblastoma. [PDF]

open access: yesPharmaceuticals (Basel)
Matteucci F   +16 more
europepmc   +1 more source

Betaine‐Conjugated ß‐Peptide Foldamers: Influence of Quaternary Charge on Self‐Organization and MorphologyFormation

open access: yesChemistryOpen, EarlyView.
N‐terminal betaine conjugation modifies β‐peptide helices, influencing folding and self‐organization. For [1S, 2S]‐ACPC, folding to an H12 helix was unaffected, while [1R, 2R]‐ACHC formed an H14 helix instead of H10. Alternating heterochiral oligomers made of enantiomeric pairs of trans‐ACPC showed enhanced solubility and E‐strand formation.
Nikolett Varró   +10 more
wiley   +1 more source

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