Results 41 to 50 of about 46,002 (241)

Piperidine-1-carboximidamide [PDF]

Acta Crystallographica Section E Structure Reports Online, 2012
In the title compound, C(6)H(13)N(3), the C=N and C-N bond lengths in the CN(3) unit are 1.3090 (17), and 1.3640 (17) (C-NH(2)) and 1.3773 (16) Å, indicating double- and single-bond character, respectively. The N-C-N angles are 116.82 (12), 119.08 (11) and 124.09 (11)°, showing a deviation of the CN(3) plane from an ideal trigonal-planar geometry.
openaire   +2 more sources

Novel chemical entities inhibiting Mycobacterium tuberculosis growth identified by phenotypic high-throughput screening

Scientific Reports, 2022
We performed a high-throughput phenotypic whole cell screen of Mycobacterium tuberculosis against a diverse chemical library of approximately 100,000 compounds from the AbbVie corporate collection and identified 24 chemotypes with anti-tubercular ...
Anuradha Kumar, Somsundaram Chettiar, Brian S. Brown, Julie Early, Juliane Ollinger, Megan Files, Mai A. Bailey, Aaron Korkegian, Devon Dennison, Matthew McNeil, James Metz, Augustine Osuma, Michael Curtin, Aaron Kunzer, Gail Freiberg, Milan Bruncko, Dale Kempf, Tanya Parish   +17 more
doaj   +1 more source

Pyrrolidines and Piperidines by Ligand‐Enabled Aza‐Heck Cyclizations and Cascades of N‐(Pentafluorobenzoyloxy)carbamates

Angewandte Chemie, 2018
Ligand‐enabled aza‐Heck cyclizations and cascades of N‐(pentafluorobenzoyloxy)carbamates are described. These studies encompass the first examples of efficient non‐biased 6‐exo aza‐Heck cyclizations. The methodology provides direct and flexible access to
I. Hazelden, Rafaela C Carmona, T. Langer, P. Pringle, J. Bower   +4 more
semanticscholar   +1 more source

Enantioselective Synthesis of Tetrahydropyridines/Piperidines via Stepwise [4 + 2]/[2 + 2] Cyclizations.

Organic Letters, 2017
A phosphine-catalyzed novel enantioselective [4 + 2]-annulation reaction between allene ketones and 1-azadienes has been developed, and tetrahydropyridines were obtained in good yields and with excellent enantioselectivities.
Zhen Wang, Huacheng Xu, Qin Su, Ping Hu, Pan‐Lin Shao, Yun He, Yixin Lu   +6 more
semanticscholar   +1 more source

Facile and Green Synthesis of Saturated Cyclic Amines

Molecules, 2017
Single-nitrogen containing saturated cyclic amines are an important part of both natural and synthetic bioactive compounds. A number of methodologies have been developed for the synthesis of aziridines, azetidines, pyrrolidines, piperidines, azepanes and
Arruje Hameed, Sadia Javed, Razia Noreen, Tayyaba Huma, Sarosh Iqbal, Huma Umbreen, Tahsin Gulzar, Tahir Farooq   +7 more
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Anodic benzylic C(sp3)–H amination: unified access to pyrrolidines and piperidines

, 2018
An electrochemical aliphatic C–H amination strategy was developed to access the important heterocyclic motifs of pyrrolidines and piperidines within a uniform reaction protocol. The mechanism of this unprecedented C–H amination strategy involves anodic C–
Sebastian Herold, Daniel Bafaluy, K. Muñiz   +2 more
semanticscholar   +1 more source

Gold(I)-Catalyzed Enantioselective Annulations between Allenes and Alkene-Tethered Oxime Ethers: A Straight Entry to Highly Substituted Piperidines and aza-Bridged Medium-Sized Carbocycles.

Journal of the American Chemical Society, 2018
Piperidine scaffolds are present in a wide range of bioactive natural products and are therefore considered as highly valuable, privileged synthetic targets.
David C Marcote, Iván Varela, J. Fernández-Casado, J. Mascareñas, F. López   +4 more
semanticscholar   +1 more source

4-AMINOPIPERIDINAS Y ESPIRO-4-PIPERIDINAS: IMPORTANCIA FARMACOLÓGICA Y ESFUERZOS SINTÉTICOS

Universitas Scientiarum, 2007
The piperidine compounds from natural or synthetic origin are of a great scientific interest due to his widestatus of biological activities: analgesic, neuroleptic, neurotropic, etc.
L. Y. Vargas-Méndez, V. V. Kouznetsov
doaj  

Fused bicyclic piperidines and dihydropyridines by dearomatising cyclisation of the enolates of nicotinyl-substituted esters and ketones

Beilstein Journal of Organic Chemistry, 2010
The silyl enol ether derivatives of ketones or esters tethered by a hydrocarbon or ether linkage to the 3-position of a pyridine ring undergo dearomatising nucleophilic attack on the ring once it is activated (as an acylpyridinium species) by the ...
Heloise Brice, Jonathan Clayden, Stuart D. Hamilton   +2 more
doaj   +1 more source

Pyrrolidines and piperidines bearing chiral tertiary alcohols by nickel-catalyzed enantioselective reductive cyclization of N-alkynones

Communications Chemistry, 2018
Pyrrolidines and piperidines are important building blocks in organic synthesis. Numerous methods exist for constructing substituted pyrrolidines and piperidines.
Guodu Liu, Wenzhen Fu, Xingye Mu, Ting-Ting Wu, M. Nie, Kaidi Li, Xiaodong Xu, Wenjun Tang   +7 more
semanticscholar   +1 more source