Results 51 to 60 of about 23,915 (334)
Synthesis and kinetic resolution of N-Boc-2-arylpiperidines [PDF]
, 2014 The chiral base n-BuLi/(-)-sparteine or n-BuLi/(+)-sparteine surrogate promotes kinetic resolution of N-Boc-2-arylpiperidines by asymmetric deprotonation. The enantioenriched starting material was recovered with yields 39-48% and ers up to 97:3.
Bailey +39 more
core +1 more source
Molecules, 2013 Recent syntheses of azetidines, pyrrolidines, piperidines and azepines through cycloaddition or sigmatropic rearrangements of vinylaziridines are described. Applications to natural product synthesis and mechanistic investigations are also summarized.
Yu Mi Heo, Seung-Mann Paek
doaj +1 more source
Advanced Functional Materials, EarlyView.Oct4‐nanoscript, a biomimetic nanoparticle‐based artificial transcription factor, precisely regulates cellular rejuvenation by activating Oct4 target genes, restoring epigenetic marks, and reducing DNA damage. In a progeria model, it effectively rescued aging‐associated pathologies and extended lifespan.
Hongwon Kim +8 more
wiley +1 more source
VI.—Compounds of piperidine with phenols [PDF]
J. Chem. Soc., Trans., 1898 n ...
Rosenheim, Otto, Schidrowitz, Philip
openaire +2 more sources
First asymmetric synthesis of piperidine alkaloid (-)-morusimic acid D [PDF]
, 2008 The first asymmetric synthesis of (-)-morusimic acid D, a 2,3-trans-2,6-cis-2-methyl-6-substituted piperidin-3-ol containing alkaloid is reported. The key steps are the reductive alkylation of N,O-diprotected 3-hydroxyglutarimide, a stepwise reductive ...
Huang, Pei-Qiang +4 more
core +1 more source
Advanced Functional Materials, EarlyView.A miniaturized, label‐free, and enzyme‐free biosensor (miR‐TFT) enables direct electrical detection of microRNA (miRNA) with single‐nucleotide specificity and a detection limit of 0.6 fM. Built on a tri‐channel In2O3/ZnO heterojunction and functionalized with bespoke peptide nucleic acid (PNA) probes, the device is robust, reusable, and compatible with
Wejdan S. Al Ghamdi +5 more
wiley +1 more source
Selectivity Control in the Palladium-catalyzed Cross-coupling of Alkyl Nucleophiles [PDF]
, 2016 Site-selectivity remains a major challenge in metal-catalyzed C–H bond functionalization. Most existing strategies rely on the introduction of a directing group or on the intrinsic reactivity of the substrate.
Baudoin, Olivier
core +2 more sources
Advanced Healthcare Materials, EarlyView.Protease‐degradable hydrogels mimic dynamic cell‐matrix interactions, but controlling hydrogel degradation is a challenge. We screen libraries of peptides to identify sequences that are primarily degraded by membrane‐localized proteases. Crosslinking hydrogels with these peptides enables cell to spread and migrate while reducing matrix degradation ...
Yingjie Wu +3 more
wiley +1 more source
[Cp*Ru]-catalyzed selective coupling/hydrogenation
, 2015 International ...
Achard, Mathieu +7 more
core +2 more sources