Nickel-catalyzed transamidation of aliphatic amide derivatives. [PDF]
, 2017 Transamidation, or the conversion of one amide to another, is a long-standing challenge in organic synthesis. Although notable progress has been made in the transamidation of primary amides, the transamidation of secondary amides has remained ...
Baker, Emma L +2 more
core +1 more source
Norbornene Homopolymerization Limits Cell Spreading in Thiol–Ene Photoclick Hydrogels
Advanced Healthcare Materials, EarlyView.Thiol–norbornene click reactions are often used in the development of cell‐permissive 3D hydrogels. However, ene–ene crosslinks in other thiol–ene systems are known to limit permissivity. This study demonstrates the negative effects of norbornene homopolymerization on 3D cell spreading and circumvents the issue by modulating polymer degree of ...
James L. Gentry, Steven R. Caliari
wiley +1 more source
Workers and alate queens of Solenopsis geminata share qualitatively similar but quantitatively different venom alkaloid chemistry [PDF]
, 2015 Solenopsis geminata group (Hymenoptera: Formicidae) encompasses ant species commonly called fire ants because of their painful sting. The many physiological effects of the venom are caused by 2-methyl-6-alkyl and/or alkenylpiperidine alkaloids.
Li Chen +5 more
core +2 more sources
Supramolecular Chemistry in Metal–Organic Framework Materials
Advanced Materials, EarlyView.This review highlights synergies between reticular chemistry and supramolecular chemistry. The role of supramolecular interactions in determining framework…guest interactions and attempts to understand dynamic behavior in metal–organic frameworks (MOFs), particularly emphasizing the development of crystal sponges, studying reactions in frameworks and ...
Eugenia Miguel‐Casañ +3 more
wiley +1 more source
Orally Active MMP-1 Sparing α-tetrahydropyranyl and α-piperidinyl Sulfone Matrix Metalloproteinase (MMP) Inhibitors with Efficacy in Cancer, Arthritis, and Cardiovascular Disease [PDF]
, 2010 α-Sulfone-α-piperidine and α-tetrahydropyranyl hydroxamates were explored that are potent inhibitors of MMP’s-2, -9, and -13 that spare MMP-1, with oral efficacy in inhibiting tumor growth in mice and left-ventricular hypertrophy in rats and in the ...
Barta, Thomas E. +3 more
core +1 more source
De‐Saturation of Single‐Atom Copper Catalysts for Accelerating Propargylic Substitution Reactions
Advanced Materials, EarlyView.De‐saturation of copper‐based single‐atom catalysts (De‐sat SACs) are realized by a KOH‐mediated Joule thermal shock strategy. Benefiting from the under‐saturation coordination environment of single‐atom Cu center, De‐sat Cu SACs exhibit remarkable catalytic activity in propargylic substitution reactions, tolerating a broad range of nucleophiles (N–, C–
Qilong Cai +12 more
wiley +1 more source
Advanced Materials Interfaces, EarlyView.Metabolic glycoengineering combined with click chemistry efficiently immobilizes clickable factor H (FH)‐binding peptides onto endothelial cell surfaces, creating stable, uniform coatings that recruit FH and enhance resistance to complement‐mediated inflammation.
Jannes Felsch +7 more
wiley +1 more source
Organophotocatalysed synthesis of 2-piperidinones in one step via [1 + 2 + 3] strategy
Nature Communications, 2023 Six-membered N-containing heterocycles, such as 2-piperidinone derivatives, with diverse substitution patterns are widespread in natural products, drug molecules and serve as key precursors for piperidines.
Yi-Dan Du +6 more
doaj +1 more source
Molecules, 2020 Conformational analysis of Si-mono- and Si,Si-disubstituted silacyclohexanes as well as their analogues with a heteroatom(s) in the ring is reviewed with the focus on the recent results.
Bagrat A. Shainyan
doaj +1 more source
Conjugate addition of 2-(bromomethyl)- and 2-(2-bromoethyl)piperidine to alkyl acrylates : application towards the synthesis of 2-(methoxycarbonyl)indolizidine [PDF]
, 2009 Conjugate addition of 2-(bromomethyl)- and 2-(2-bromoethyl)piperidine hydrobromide to methyl and ethyl acrylate in the presence of triethylamine afforded the corresponding 3-[2-(bromomethyl)piperidin-1-yl]propanoates and 3-[2-(2-bromoethyl)piperidin-1-yl]
Abbaspour Tehrani, Kourosch +3 more
core +2 more sources