Results 61 to 70 of about 40,506 (345)
Organophotocatalysed synthesis of 2-piperidinones in one step via [1 + 2 + 3] strategy
Nature Communications, 2023 Six-membered N-containing heterocycles, such as 2-piperidinone derivatives, with diverse substitution patterns are widespread in natural products, drug molecules and serve as key precursors for piperidines.
Yi-Dan Du +6 more
doaj +1 more source
Recent Developments in Radical Mediated Synthesis of Organostannanes.
Advanced Synthesis &Catalysis, EarlyView.Abstract The present review aims to provide an overview of the recent developments in the preparation of aryl‐ or alkenyl stannanes via carbon‐ and tin‐centered radicals enabling chemists to synthesize organostannyl derivatives with high efficiency and under mild conditions.
Qianhang Ren +4 more
wiley +1 more source
Anodic benzylic C(sp3)–H amination: unified access to pyrrolidines and piperidines
, 2018 An electrochemical aliphatic C–H amination strategy was developed to access the important heterocyclic motifs of pyrrolidines and piperidines within a uniform reaction protocol. The mechanism of this unprecedented C–H amination strategy involves anodic C–
Sebastian Herold +2 more
semanticscholar +1 more source
Communications Chemistry, 2018 Pyrrolidines and piperidines are important building blocks in organic synthesis. Numerous methods exist for constructing substituted pyrrolidines and piperidines.
Guodu Liu +7 more
semanticscholar +1 more source
An optimized synthesis of a key pharmaceutical intermediate methyl 4-[(1-oxopropyl)phenylamino]piperidine-4-carboxylate [PDF]
Journal of the Serbian Chemical Society, 2002 An efficient synthesis of methyl 4-[(1-oxopropyl)phenylamino]piperidine-4-carboxylate (7) has been developed starting from 1-benzylpiperidin-4-one (1).
Kiricojević Vesna D. +5 more
doaj +3 more sources
Synthesis and Evaluation of Novel Iminosugars Prepared from Natural Amino Acids
Molecules, 2021 Cyclopropanated iminosugars have a locked conformation that may enhance the inhibitory activity and selectivity against different glycosidases. We show the synthesis of new cyclopropane-containing piperidines bearing five stereogenic centers from natural
Alejandro Puet +3 more
doaj +1 more source
Opportunities in Therapeutic mRNA Stabilization: Sequence, Structure, Adjuvants and Vectors
Advanced Therapeutics, EarlyView.Current mRNA lipid nanoparticles rely on cold storage, which increases the cost and reduces access to the vaccines. As mRNA expands to other clinical opportunities, better methods to stabilize the medicines during shipping, storage, and delivery are needed.
Joshua A. Choe +4 more
wiley +1 more source
Organic Letters, 2019 Mannich reactions of carbohydrate derivatives with ketones that afford polyoxy-functionalized piperidines are reported. Ketone nucleophiles (enamines/enolates) were generated in the presence of the amines used for the formation of the iminium ions of ...
Lingaiah Maram, F. Tanaka
semanticscholar +1 more source
Advanced Science, EarlyView.This study uses gut microbiome data to predict corticosteroid response in patients with immune thrombocytopenia (ITP). Fecal samples from 212 patients with ITP are sequenced. Six machine‐learning algorithms are used to train predictive models. The support vector machine‐based model integrated clinical data and selected microbial species, diversities ...
Feng‐Qi Liu +38 more
wiley +1 more source
Journal of Organic and Pharmaceutical Chemistry, 2021 Aim. To develop a convenient synthetic approach for the preparation of multigram amounts of 4-(trifluoromethoxy)-piperidine and 4-(trifluoromethoxymethyl)piperidine – promising building blocks for medicinal chemistry.Results and discussion. 4-(Trifluoromethoxy)piperidine (8.4 g) and 4-(trifluoromethoxymethyl)piperidine (12.9 g) were synthesized in 5 ...
Ivan G. Logvinenko +2 more
openaire +4 more sources