Results 61 to 70 of about 24,519 (327)

Increased Anti‐Psoriatic Effect of Anti‐Inflammatory Dendrimers Using Fluid Catanionic Vesicle‐Based Topical Formulations

Advanced Healthcare Materials, EarlyView.
Next‐Generation Psoriasis Therapy – With advanced dendrimer‐based formulations, this study paves the way for highly effective, skin‐permeable treatments. Encapsulated in fluid catanionic vesicles, IMD‐006 and its analogues show promising anti‐psoriatic effects offering a targeted, non‐invasive approach to managing chronic skin inflammation.
Ranime Jebbawi, Abdelouahd Oukhrib, Emily Clement, Hélène Labie, Stéphanie Cassel, Séverine Fruchon, Anne‐Marie Caminade, Michel Simon, Rémy Poupot, Cédric‐Olivier Turrin, Muriel Blanzat   +10 more
wiley   +1 more source

4-AMINOPIPERIDINAS Y ESPIRO-4-PIPERIDINAS: IMPORTANCIA FARMACOLÓGICA Y ESFUERZOS SINTÉTICOS

Universitas Scientiarum, 2007
The piperidine compounds from natural or synthetic origin are of a great scientific interest due to his widestatus of biological activities: analgesic, neuroleptic, neurotropic, etc.
L. Y. Vargas-Méndez, V. V. Kouznetsov
doaj  

Transaminase triggered aza-Michael approach for the enantioselective synthesis of piperidine scaffolds [PDF]

, 2016
The expanding “toolbox” of biocatalysts opens new opportunities to redesign synthetic strategies to target molecules by incorporating a key enzymatic step into the synthesis.
Andrew Gomm, Beatriz Maciá, Elaine O’Reilly, James Ryan, Mindaugas Šiaučiulis, Stewart J., Vittorio Caprio   +6 more
core   +3 more sources

Supramolecular Chemistry in Metal–Organic Framework Materials

Advanced Materials, EarlyView.
This review highlights synergies between reticular chemistry and supramolecular chemistry. The role of supramolecular interactions in determining framework…guest interactions and attempts to understand dynamic behavior in metal–organic frameworks (MOFs), particularly emphasizing the development of crystal sponges, studying reactions in frameworks and ...
Eugenia Miguel‐Casañ, Georgia R. F. Orton, Danielle E. Schier, Neil R. Champness   +3 more
wiley   +1 more source

Orally Active MMP-1 Sparing α-tetrahydropyranyl and α-piperidinyl Sulfone Matrix Metalloproteinase (MMP) Inhibitors with Efficacy in Cancer, Arthritis, and Cardiovascular Disease [PDF]

, 2010
α-Sulfone-α-piperidine and α-tetrahydropyranyl hydroxamates were explored that are potent inhibitors of MMP’s-2, -9, and -13 that spare MMP-1, with oral efficacy in inhibiting tumor growth in mice and left-ventricular hypertrophy in rats and in the ...
Barta, Thomas E., Becker, Daniel P, Bedell, Louis J., Boehm, Terri L.   +3 more
core   +1 more source

A Pseudo‐Mytilus Edulis Foot Protein‐Based Hydrogel Adhesive with Osteo‐Vascular‐Immune Coupling Effects for Osteoporotic Bone‐Implant Integration

Advanced Materials, EarlyView.
Inspired by mussel proteins, YDC‐Gel‐Zn is a smart bone glue designed for osteoporotic implants. It adheres strongly to both metal implants and bone for initial fixation. In osteoporosis's inflammatory environment, it sequentially releases zinc ions and therapeutic peptides: the zinc modulates immune cells to reduce inflammation, while the peptides ...
Wentao Wang, Zhenyu Li, Siming Zhang, Yue Ma, Lei Yu, Qidong Zhang, Guoqing Pan, Dechun Geng, Chen Zhu, Jiaxiang Bai   +9 more
wiley   +1 more source

Nickel-catalyzed transamidation of aliphatic amide derivatives. [PDF]

, 2017
Transamidation, or the conversion of one amide to another, is a long-standing challenge in organic synthesis. Although notable progress has been made in the transamidation of primary amides, the transamidation of secondary amides has remained ...
Baker, Emma L, Dander, Jacob E, Garg, Neil K   +2 more
core   +1 more source

Design and Utilization of Stable Hydrofluoroolefin‐Based Trifluoropropynyl Surrogate for Sonogashira Coupling

Advanced Synthesis &Catalysis, EarlyView.
A novel methodology for the construction of aromatic and heteroaromatic trifluoropropynyl derivatives has been developed. The new protocol is based on a tandem Sonogashira cross‐coupling reaction between a bench‐stable trifluoropropynyl carbinol reagent, generated from the commercially available and inexpensive hydrofluoroolefin‐1234yf gas, and (hetero)
Emma Bodnár, Ferenc Béke, Klára Aradi, Zoltán Novák   +3 more
wiley   +1 more source

Base-catalyzed reactions of environmentally relevant N-chloro-piperidines. A quantum-chemical study [PDF]

, 2011
Electronic structure methods have been applied to calculate the gas and aqueous phase reaction energies for base-induced rearrangements of N-chloropiperidine, N-chloro-3-(hydroxymethyl)piperidine, and N-chloro-4-4-fluorophenyl)-3-(hydroxymethyl ...
Sakic, Davor, Vrcek, Valerije, Zipse, Hendrik   +2 more
core   +1 more source

Synthesis of Functionalized Homoallylic Alcohols via a Salt‐Free Three‐Component Nickel‐Catalyzed Coupling Reaction

Advanced Synthesis &Catalysis, EarlyView.
A nickel catalyzed three‐component coupling reaction between an aldehyde, a secondary amine, and butadiene allows a straightforward access to 5‐aminopent‐3‐en‐1‐ol scaffolds according to a salt‐free process. Key steps are oxidative coupling reaction between one aldehyde, one butadiene on a low valent nickel precursor, and the nucleophilic attack of a ...
Anthony Saint Pol, Maxime Roger, Alexis Mifleur, Pauline Loxq, Laëtitia Chausset‐Boissarie, Aurélien Béthegnies, Maël Penhoat, Isabelle Suisse, Mathieu Sauthier   +8 more
wiley   +1 more source