Biological and Pharmaceutical Bulletin, 2006 Dai-kenchu-to has been used for the treatment of abdominal obstructions, including bowel obstructions and a feeling of coldness in the abdomen. We reported that Dai-kenchu-to increases plasma neuropeptide [motilin, vasoactive intestinal polypeptide (VIP),
Yuhki Sato +4 more
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BDNF/TrkB signalling, in cooperation with muscarinic signalling, retrogradely regulates PKA pathway to phosphorylate SNAP-25 and Synapsin-1 at the neuromuscular junction [PDF]
Cell Communication and SignalingBackground Protein kinase A (PKA) enhances neurotransmission at the neuromuscular junction (NMJ), which is retrogradely regulated by nerve-induced muscle contraction to promote Acetylcholine (ACh) release through the phosphorylation of molecules involved
Aleksandra Polishchuk +10 more
doaj +2 more sources
Blood disorders associated with pirenzepine. [PDF]
BMJ, 1986 R. H. B. Meyboom +3 more
openaire +5 more sources
Influence of ranitidine, pirenzepine, and aluminum magnesium hydroxide on the bioavailability of various antibiotics, including amoxicillin, cephalexin, doxycycline, and amoxicillin-clavulanic acid [PDF]
Antimicrobial Agents and Chemotherapy, 1989 K.-M. Deppermann +5 more
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Identification of M1 muscarinic receptors in pulmonary sympathetic nerves in the guinea‐pig by use of pirenzepine [PDF]
British Journal of Pharmacology, 1989 Jennifer Maclagan +2 more
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Rational Design in Photopharmacology with Molecular Photoswitches
Angewandte Chemie, Volume 135, Issue 30, July 24, 2023., 2023 The state of the art of rational design in photopharmacology is analyzed with a focus on E‐Z molecular photoswitches and on computer‐aided approaches. By meticulously examining the design strategies of photopharmacology through the lens of medicinal chemistry, this review identifies existing trends and novel opportunities for the development of ...
Piermichele Kobauri +3 more
wiley +2 more sources
Treatment of duodenal ulcer with pirenzepine and cimetidine. [PDF]
Gut, 1984 The purpose of this single blind controlled multicentre trial was to compare the relative effectiveness of pirenzepine and cimetidine in healing endoscopically proven duodenal ulcers. One hundred and twenty six patients with duodenal ulcer were treated with a daily dose of 100 mg pirenzepine (50 mg each before breakfast and before the evening meal ...
K Schütze +9 more
openaire +2 more sources
Scientific Reports, 2022 Organophosphorus (OP) compounds that inhibit acetylcholinesterase are a common cause of poisoning worldwide, resulting in several hundred thousand deaths each year.
Oksana A. Lenina, Konstantin A. Petrov
doaj +1 more source
ESC Heart Failure, Volume 10, Issue 6, Page 3311-3329, December 2023., 2023 Abstract Aims We aim to explore the role and mechanism of vagus nerve stimulation (VNS) in coronary endothelial cells and angiogenesis in infarcted hearts. Methods and results Seven days after rat myocardial infarction (MI) was prepared by ligation of the left anterior descending coronary artery, the left cervical vagus nerve was treated with ...
Yan Wang +14 more
wiley +1 more source
Clozapine for the treatment of aggressiveness and agitation in advanced dementia
Psychogeriatrics, Volume 23, Issue 6, Page 963-972, November 2023., 2023 Abstract Background Distressing behavioural symptoms, particularly agitation and aggressiveness, remain a difficult problem in everyday clinical practice in the treatment of multimorbid patients with dementia. Clozapine may be an effective therapeutic alternative in this context.
Arwed E. Michael +3 more
wiley +1 more source