Results 21 to 30 of about 2,792 (196)

Characteristics of Cerebrovascular Response to Intrinsic Vasoactive Substances in Sika Deer (Cervus nippon yesoensis) and the Possible Effects of Gravity on Adrenergic Responses [PDF]

Animals
Gravity may exert species-specific effects on quadrupedal vasoreactivity, reflecting variations in the vertical displacement of the cardiocranial axis from the dorsal plane.
Md. Zahorul Islam, Siyuan Wu, Tomoki Ootawa, Henry Smith, Ha Thi Thanh Nguyen, Etsumori Harada, Atsushi Miyamoto   +6 more
doaj   +2 more sources

Poly (ADP-Ribose) Polymerase-1 (PARP1) Deficiency and Pharmacological Inhibition by Pirenzepine Protects From Cisplatin-Induced Ototoxicity Without Affecting Antitumor Efficacy [PDF]

Frontiers in Cellular Neuroscience, 2019
Cisplatin remains an indispensable drug for the systemic treatment of many solid tumors. However, a major dose-limiting side-effect is ototoxicity. In some scenarios, such as treatment of germ cell tumors or adjuvant therapy of non-small cell lung cancer,
Anke Tropitzsch, Marcus Müller, François Paquet-Durand, Frank Mayer, Hans-Georg Kopp, Andre Schrattenholz, Andrea Müller, Hubert Löwenheim   +7 more
doaj   +2 more sources

Two-point immobilization of M3 muscarinic receptor: a method for recognizing receptor antagonists in natural products [PDF]

BMC Chemistry
In the investigation of active ingredients from natural products, current technologies relying on drug–target affinity recognition analysis face significant challenges.
Xiaomin Huang, Ting Wang, Ludan Wang, Yantao Sun, Ziru Zhang, Yajun Zhang   +5 more
doaj   +2 more sources

A comparative study of Pirenzepine and Ranitidine effects on treatment of gastric ulcer in rat

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 1999
Objective: The gastrointestinal diseases, specially peptic ulcer, are among the most common diseases, and a large number of investigations have been carried out about etiology, prevention and treatment of these diseases.
A Arzi, M Khalili
doaj   +1 more source

Adreno-Muscarinic Synergy of Contractile Responses From Human Hyperplastic Prostate [PDF]

International Neurourology Journal
Purpose Adreno-muscarinic synergy, a supra-additional contractile response to simultaneous application of α-adrenoreceptor and muscarinic receptor agonists, is a feature of several lower urinary tract regions that have dual sympathetic and ...
Ben T. Blake-James, Basu Chakrabarty, Christopher H. Fry   +2 more
doaj   +2 more sources

Blood disorders associated with pirenzepine. [PDF]

BMJ, 1986
B H, Stricker, R H, Meyboom, P A, Bleeker, K, van Wieringen   +3 more
openaire   +4 more sources

Cholinergic Signaling Mediated by Muscarinic Receptors Triggers the Ultraviolet-Induced Release of Melanosome in Cultured Melanoma Cells. [PDF]

Pigment Cell Melanoma Res
Schematic diagram illustrating the role of mAChRs in UVB‐mediated melanosome release. Under UVB irradiation, the epidermal keratinocytes and melanocytes release ACh. ACh stimulates M1/M3 mAChRs and leads to activation of PLC, which thereafter increases the levels of IP3 and DAG, as well as the intracellular Ca2+ and PKC. In addition, the expressions of
Guo MS, Wu Q, Xia Y, Wu J, Wang X, Yuen GKW, Dong TT, Gao J, Tsim KWK.   +8 more
europepmc   +2 more sources

Evaluation of the Alterations in Central Cholinergic Neurotransmission in Aging and Amyloid Precursor Protein Knock-In Mice. [PDF]

J Neurochem
In Alzheimer's disease, reduced release of ACh is linked more to Aβ pathology than to age‐related change, highlighting an early sign of disease. ABSTRACT A progressive decline in cognitive function occurs as a result of aging and Alzheimer's disease (AD) and is primarily associated with diminished cholinergic neurotransmission.
Nagai-Arakawa I, Muramatsu I, Uwada J, Tsuda Y, Tokunaga A, Irie A, Maeda H, Madokoro Y, Sato T, Uchida Y, Saito T, Saido TC, Sada K, Masuoka T, Matsukawa N.   +14 more
europepmc   +2 more sources

Prevention of HIV-1 TAT Protein-Induced Peripheral Neuropathy and Mitochondrial Disruption by the Antimuscarinic Pirenzepine

Frontiers in Neurology, 2021
HIV-associated distal sensory polyneuropathy (HIV-DSP) affects about one third of people with HIV and is characterized by distal degeneration of axons. The pathogenesis of HIV-DSP is not known and there is currently no FDA-approved treatment.
May Madi Han, Katie E. Frizzi, Ronald J. Ellis, Ronald J. Ellis, Nigel A. Calcutt, Jerel Adam Fields   +5 more
doaj   +1 more source

Rational Design in Photopharmacology with Molecular Photoswitches

Angewandte Chemie, Volume 135, Issue 30, July 24, 2023., 2023
The state of the art of rational design in photopharmacology is analyzed with a focus on E‐Z molecular photoswitches and on computer‐aided approaches. By meticulously examining the design strategies of photopharmacology through the lens of medicinal chemistry, this review identifies existing trends and novel opportunities for the development of ...
Piermichele Kobauri, Frank J. Dekker, Wiktor Szymanski, Ben L. Feringa   +3 more
wiley   +2 more sources