Results 31 to 40 of about 5,284 (226)

The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors

open access: yesBritish Journal of Pharmacology, Volume 180, Issue S2, Page S23-S144, October 2023., 2023
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands.
Stephen P. H. Alexander   +165 more
wiley   +1 more source

Effects of Mlx-8, a phospholipase A2 from Brazilian coralsnake Micrurus lemniscatus venom, on muscarinic acetylcholine receptors in rat hippocampus [PDF]

open access: yesJournal of Venomous Animals and Toxins including Tropical Diseases, 2020
Background: Here, we described the presence of a neurotoxin with phospholipase A2 activity isolated from Micrurus lemniscatus venom (Mlx-8) with affinity for muscarinic acetylcholine receptors (mAChRs).
Roberta Tancredi Francesco dos Santos   +7 more
doaj   +1 more source

The 100 Most Frequently Cited Articles on Myopia

open access: yesJournal of Ophthalmology, Volume 2023, Issue 1, 2023., 2023
Purpose. To provide a bibliographical‐historical perspective and main interest in the field of myopia. Methods. In this bibliographic study, the Web of Science Database was searched from 1999 to 2018. Recorded parameters included journal name, impact factor, year and language, number of authors, type and origin, methodology, number of subjects, funding,
Rachel Shemesh   +4 more
wiley   +1 more source

Muscarinic acetylcholine M1 receptor regulates pyroptosis of prostate cancer cells through Caspase-1/GSDMD pathway

open access: yesDi-san junyi daxue xuebao, 2021
Objective To determine the effect of muscarinic acetylcholine M1 receptor (CHRM1) on pyroptosis of prostate cancer cells and investigate its possible molecular mechanism. Methods Pirenzepine (PIN), a specific CHRM1 antagonist, and bethanechol (BETH), its
CHEN Jinying   +6 more
doaj   +1 more source

Corticosteroids in patients with vestibular neuritis: An updated meta‐analysis

open access: yesActa Neurologica Scandinavica, Volume 146, Issue 5, Page 429-439, November 2022., 2022
Vestibular neuritis is a common neuro‐otological entity. Therapeutically, corticosteroids are advised, although the evidence is limited. The objective of this review is to update meta‐analyses of clinical trials that address the question of whether patients with vestibular neuritis treated with corticosteroids show better recovery than control patients.
Anna Bogdanova   +3 more
wiley   +1 more source

Additive interaction of intrathecal ginsenosides and neostigmine in the rat formalin test [PDF]

open access: yesKorean Journal of Anesthesiology, 2013
BackgroundThe authors evaluated the effect of intrathecal mixture of ginsenosides with neostigmine on formalin-induced nociception and made further clear the role of the spinal muscarinic (M) receptors on the activity of ginsenosides.MethodsA catheter ...
Cheon-Hee Park   +3 more
doaj   +1 more source

Muscarinic receptors in the rat ovary are involved in follicular development but not in steroid secretion

open access: yesPhysiological Reports, Volume 10, Issue 21, November 2022., 2022
Role of Acetylcholine in steroid biosynthesis and follicular development in the rat ovary. The follicles of the rat ovary do not receive a direct extraovarian cholinergic innervation. It mainly originated from an intraovarian source of Acetylcholine (a).
Fernanda C. Cuevas   +8 more
wiley   +1 more source

The activation of M2 muscarinic receptor inhibits cell growth and survival in human epithelial ovarian carcinoma

open access: yesJournal of Cellular Biochemistry, Volume 123, Issue 9, Page 1440-1453, September 2022., 2022
Abstract Ovarian cancer is the fifth leading cause of cancer‐related deaths in females. Many ovarian tumor cell lines express muscarinic receptors (mAChRs), and their expression is correlated with reduced survival of patients. We have characterized the expression of mAChRs in two human ovarian carcinoma cell lines (SKOV‐3, TOV‐21G) and two immortalized
Marilena Taggi   +7 more
wiley   +1 more source

Pharmacological and molecular characterization of the A‐type muscarinic acetylcholine receptor from Anopheles gambiae

open access: yesInsect Molecular Biology, Volume 31, Issue 4, Page 497-507, August 2022., 2022
A‐type mAChR was identified in Anopheles gambiae larvae and adult mosquitoes Activation of An. gambiae mAChR‐A which is coupled to phosphoinositide pathway induced intracellular calcium increase An. gambiae mAChR‐A is mainly blocked by 4‐DAMP known as M3 mAChR antagonist in mammals Summary showing the pharmacology of Anopheles gambiae mAChR‐A and its ...
Alexandre Pilon   +2 more
wiley   +1 more source

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