Results 51 to 60 of about 2,792 (196)

Muscarinic Acetylcholine Type 1 Receptor Activity Constrains Neurite Outgrowth by Inhibiting Microtubule Polymerization and Mitochondrial Trafficking in Adult Sensory Neurons

Frontiers in Neuroscience, 2018
The muscarinic acetylcholine type 1 receptor (M1R) is a metabotropic G protein-coupled receptor. Knockout of M1R or exposure to selective or specific receptor antagonists elevates neurite outgrowth in adult sensory neurons and is therapeutic in diverse ...
Mohammad G. Sabbir, Nigel A. Calcutt, Paul Fernyhough, Paul Fernyhough   +3 more
doaj   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: G protein‐coupled receptors

British Journal of Pharmacology, Volume 182, Issue S1, Page S24-S151, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Anthony P. Davenport, Eamonn Kelly, Alasdair J. Gibb, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Maria Pia Abbracchio, George R. Abraham, Alexander Agoulnik, Wayne Alexander, Khaled Al‐hosaini, Magnus Bäck, Jillian G. Baker, Nicholas M. Barnes, Ross Bathgate, Jean‐Martin Beaulieu, Annette G. Beck‐Sickinger, Maik Behrens, Kirstie A. Bennett, Kenneth E. Bernstein, Bernhard Bettler, Nigel J. M. Birdsall, Victoria A. Blaho, Pascal Bonaventure, Francois Boulay, Corinne Bousquet, Hans Bräuner‐Osborne, Andrew J. Brown, Geoffrey Burnstock, Marta Busnelli, Girolamo Caló, Vanni Caruso, Justo P. Castaño, Kevin J. Catt, Stefania Ceruti, Paul Chazot, Nan Chiang, Bice Chini, Arthur Christopoulos, Jerold Chun, Antonia Cianciulli, Olivier Civelli, Lucie H. Clapp, Réjean Couture, Helen M. Cox, Zsolt Csaba, Claes Dahlgren, Frank M. Dautzenberg, Gordon Dent, Steven D. Douglas, Pascal Dournaud, Margarita L. Dubocovich, Satoru Eguchi, Emanuel Escher, Edward J. Filardo, Tung Fong, Huamei Fu Forsman, Marta Fumagalli, Raul R. Gainetdinov, Michael L. Garelja, Marc de Gasparo, Florence Gbahou, Craig Gerard, Marvin Gershengorn, Michelle Glass, David E. Gloriam, Fernand Gobeil, Theodore L. Goodfriend, Cyril Goudet, Lukas Grätz, Karen J. Gregory, Christian Gruber, Andrew L. Gundlach, Jörg Hamann, Julien Hanson, Deborah S. Hartman, Richard L. Hauger, Debbie L. Hay, Akos Heinemann, Laura Heitman, Deron R. Herr, Morley D. Hollenberg, Nicholas D. Holliday, Birgitte Holst, Mastgugu Horiuchi, Daniel Hoyer, László Hunyady, Ahsan Husain, Adriaan P. IJzerman, Tadashi Inagami, Paul A. Insel, Kenneth A. Jacobson, Laura H. Jacobson, Robert T. Jensen, Ralf Jockers, Deepa Jonnalagadda, Sadashiva Karnik, Klemens Kaupmann, Jacqueline Kemp, Charles Kennedy, Yasuyuki Kihara, Julia Kinsolving, Takio Kitazawa, Pawel Kozielewicz, Hans‐Jürgen Kreienkamp, Jyrki P. Kukkonen, Luxmichan Laishram, Tobias Langenhan, Christopher J. Langmead, Dan Larhammar, Katie Leach, Davide Lecca, John D. Lee, Susan E. Leeman, Jérôme Leprince, Rob Leurs, Xaria X. Li, Ines Liebscher, Stephen J. Lolait, Amelie Lupp, Robyn Macrae, Janet J. Maguire, Davide Malfacini, Maurice Manning, Davide Marangon, Kirill Martemyanov, Jean Mazella, Craig A. McArdle, Shlomo Melmed, Martin C. Michel, Laurence J. Miller, Vincenzo Mitolo, Bernard Mouillac, Christa E. Müller, Philip M. Murphy, Jean‐Louis Nahon, Richard R. Neubig, Tony Ngo, Xavier Norel, Duuamene Nyimanu, Anne‐Marie O’Carroll, Stefan Offermanns, Maria Antonietta Panaro, Marc Parmentier, Nicole Perry‐Hauser, Roger G. Pertwee, Jean‐Philippe Pin, Eric R. Prossnitz, Helena Chengxue Qin, Mark Quinn, Stefano Raffaele, Rithwik Ramachandran, Manisha Ray, Rainer K. Reinscheid, Alejandro Romeral Buzón, Philippe Rondard, Mette M. Rosenkilde, G. Enrico Rovati, Chiara Ruzza, Gareth J. Sanger, Nicole Scholz, Torsten Schöneberg, Gunnar Schulte, Stefan Schulz, Deborah L. Segaloff, Charles N. Serhan, Arun K. Shukla, Khuraijam Dhanachandra Singh, Craig M. Smith, Nicola J. Smith, Claudia Stäubert, Leigh A. Stoddart, Yukihiko Sugimoto, Roger Summers, Valerie P. Tan, David M. Thal, Walter ( Wally) Thomas, Pieter B. M. W. M. Timmermans, Kalyan Tirupula, Lawrence Toll, Giovanni Tulipano, Hamiyet Unal, Thomas Unger, Celine Valant, Patrick Vanderheyden, David Vaudry, Hubert Vaudry, Joseph G. Verbalis, Jean‐Pierre Vilardaga, Christopher S. Walker, Ji Ming Wang, Donald T. Ward, Hans‐Jürgen Wester, Gary B. Willars, Tom Lloyd Williams, Trent M. Woodruff, Huixian Wu, Cheng Yang, Chengcan Yao, Richard D. Ye, Nathan Zaidman   +206 more
wiley   +1 more source

EXPLORING ANTIHYPERTENSIVE DRUG LEADS FROM BLIGHIA SAPIDA K. D. KOENIG VIA GC-MS AND IN SILICO APPROACHES [PDF]

Journal of Plant Development
Globally, hypertension is a leading cause of cardiovascular diseases that account for around 17 million deaths. Despite more studies and management measures, the cause of hypertension is barely unknown, auxiliary antihypertensive medications have some ...
Comfort Titilayomi SENJOBI, Daniel Oriola SHOKOYA, Oladimeji Emmanuel SOREMEKUN, Abimbola Heritage SENJOBI, Ezekiel Abiola OLUGBOGI, Olubukola Iretiola LAWAL, Olaitan Chinenye OKECHUKWU, Afui Olugbenga ETTU, Muhali Olaide JIMOH, Samuel Oloruntoba BAMIGBOYE, Elizabeth Olajumoke Olabisi OYEWOLE   +10 more
doaj   +1 more source

Light‐Activated Pharmacological Tools for Exploring the Cholinergic System

Medicinal Research Reviews, Volume 45, Issue 4, Page 1251-1274, July 2025.
ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Alessio Colleoni, Giulia Galli, Clelia Dallanoce, Marco De Amici, Pau Gorostiza, Carlo Matera   +5 more
wiley   +1 more source

Powikłania ze strony przewodu pokarmowego w trakcie leczenia klozapiną

Psychiatria i Psychologia Kliniczna, 2015
Klozapina jest ostateczną opcją terapeutyczną w przypadku pacjentów ze schizofrenią oporną na leczenie. Podczas terapii często występują działania niepożądane ze strony przewodu pokarmowego: ślinotok, zaparcia, niedrożność jelit, niewydolność wątroby ...
Adam Wysokiński
doaj   +1 more source

Homecare amyotrophic lateral sclerosis (ALS): A multidisciplinary, home‐based model of care for patients with ALS and their caregivers

Muscle &Nerve, Volume 70, Issue 5, Page 937-943, November 2024.
Abstract Introduction/Aims Multidisciplinary care for patients with amyotrophic lateral sclerosis (ALS) is recommended in international guidelines, but reaches its limits when immobility increases. This pilot project addresses this gap by delivering home‐based, specialized, multiprofessional support to ALS patients who are not able to attend outpatient
Sarah Kristina Bublitz, Magdalena Eham, Helena Ellrott, Benno Littger, Jana Richter, Stefan Lorenzl   +5 more
wiley   +1 more source

Neural control of tumor immunity

The FEBS Journal, Volume 291, Issue 21, Page 4670-4679, November 2024.
Cancers are innervated by sensory, sympathetic and/or parasympathetic nerves. Interactions between these nerves, cancer cells as well as immune cells regulate overall tumor progression. While this indicates that the peripheral nervous system could be a potential target for promoting anti‐tumor immune responses, the precise mechanisms underlying nerve ...
Burak Kizil, Francesco De Virgiliis, Christoph Scheiermann   +2 more
wiley   +1 more source

Dealing With Clozapine-Induced Sialorrhea

European Psychiatry, 2022
Introduction Clozapine is the first atypical antipsychotic. It is used in refractory schizophrenia. It has a heavy side effect burden, including weight gain, dizziness, blurred vision, and sialorrhea.
J. Sá Couto, B. Da Luz, M. Pão Trigo, J. Rodrigues, T. Ventura Gil   +4 more
doaj   +1 more source

Neural Influences on Tumor Progression Within the Central Nervous System

CNS Neuroscience &Therapeutics, Volume 30, Issue 10, October 2024.
Neurons can establish connections with tumor cells via chemical or electrical synapses, regulating the progression of tumors in the central nervous system. In addition, they can also enhance tumor proliferation and the formation of neurogliomal synapses by secreting proteins into the tumor microenvironment through paracrine signaling.
Wenhao Lv, Yongjie Wang
wiley   +1 more source

Functional neuroanatomy of basal forebrain projections to the basolateral amygdala: Transmitters, receptors, and neuronal subpopulations

Journal of Neuroscience Research, Volume 102, Issue 3, March 2024.
Diagram illustrating the innervation of basolateral amygdalar pyramidal projection neurons (PN) and parvalbumin‐expressing interneurons (PV) by cholinergic (ACh) and GABAergic neurons of the basal forebrain, including what is known about the distribution of muscarinic receptors (M1 and M2) expressed by these structures, as well as cortical and thalamic
Alexander Joseph McDonald
wiley   +1 more source