Results 51 to 60 of about 5,364 (186)

Light‐Activated Pharmacological Tools for Exploring the Cholinergic System

open access: yesMedicinal Research Reviews, Volume 45, Issue 4, Page 1251-1274, July 2025.
ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Alessio Colleoni   +5 more
wiley   +1 more source

Powikłania ze strony przewodu pokarmowego w trakcie leczenia klozapiną

open access: yesPsychiatria i Psychologia Kliniczna, 2015
Klozapina jest ostateczną opcją terapeutyczną w przypadku pacjentów ze schizofrenią oporną na leczenie. Podczas terapii często występują działania niepożądane ze strony przewodu pokarmowego: ślinotok, zaparcia, niedrożność jelit, niewydolność wątroby ...
Adam Wysokiński
doaj   +1 more source

Dealing With Clozapine-Induced Sialorrhea

open access: yesEuropean Psychiatry, 2022
Introduction Clozapine is the first atypical antipsychotic. It is used in refractory schizophrenia. It has a heavy side effect burden, including weight gain, dizziness, blurred vision, and sialorrhea.
J. Sá Couto   +4 more
doaj   +1 more source

Homecare amyotrophic lateral sclerosis (ALS): A multidisciplinary, home‐based model of care for patients with ALS and their caregivers

open access: yesMuscle &Nerve, Volume 70, Issue 5, Page 937-943, November 2024.
Abstract Introduction/Aims Multidisciplinary care for patients with amyotrophic lateral sclerosis (ALS) is recommended in international guidelines, but reaches its limits when immobility increases. This pilot project addresses this gap by delivering home‐based, specialized, multiprofessional support to ALS patients who are not able to attend outpatient
Sarah Kristina Bublitz   +5 more
wiley   +1 more source

Neural control of tumor immunity

open access: yesThe FEBS Journal, Volume 291, Issue 21, Page 4670-4679, November 2024.
Cancers are innervated by sensory, sympathetic and/or parasympathetic nerves. Interactions between these nerves, cancer cells as well as immune cells regulate overall tumor progression. While this indicates that the peripheral nervous system could be a potential target for promoting anti‐tumor immune responses, the precise mechanisms underlying nerve ...
Burak Kizil   +2 more
wiley   +1 more source

Neural Influences on Tumor Progression Within the Central Nervous System

open access: yesCNS Neuroscience &Therapeutics, Volume 30, Issue 10, October 2024.
Neurons can establish connections with tumor cells via chemical or electrical synapses, regulating the progression of tumors in the central nervous system. In addition, they can also enhance tumor proliferation and the formation of neurogliomal synapses by secreting proteins into the tumor microenvironment through paracrine signaling.
Wenhao Lv, Yongjie Wang
wiley   +1 more source

In vitro release of two anti-muscarinic drugs from soft contact lenses

open access: yesClinical Ophthalmology, 2017
Alex Hui,1 Magdalena Bajgrowicz-Cieslak,2 Chau-Minh Phan,3 Lyndon Jones3 1School of Optometry and Vision Science, UNSW Sydney, Sydney, NSW, Australia; 2Department of Mechanics, Material Science and Engineering, Wroclaw University of Technology, Wroclaw,
Hui A   +3 more
doaj  

Activation of M1 mAChRs by lesatropane rescues glutamate neurotoxicity in PC12 cells via PKC-mediated phosphorylation of ERK1/2

open access: yesBiomolecules & Biomedicine, 2013
Lesatropane, a synthesized chiral tropane (3S, 6S-isomer of satropane), is a novel muscarinic agonist, and is being under preclinical development in China for the treatment of primary glaucoma.
Ke Ma   +4 more
doaj   +1 more source

Muscarinic depolarization of layer II neurons of the parasubiculum. [PDF]

open access: yesPLoS ONE, 2013
The parasubiculum (PaS) is a component of the hippocampal formation that sends its major output to layer II of the entorhinal cortex. The PaS receives strong cholinergic innervation from the basal forebrain that is likely to modulate neuronal ...
Stephen D Glasgow, C Andrew Chapman
doaj   +1 more source

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