Results 61 to 70 of about 372,448 (315)

Translational Windows in Chordoma: A Target Appraisal

Frontiers in Neurology, 2020
Chordomas are rare tumors that are notoriously refractory to chemotherapy and radiotherapy when radical surgical resection is not achieved or upon recurrence after maximally aggressive treatment.
Samantha E. Hoffman, Sally A. Al Abdulmohsen, Saksham Gupta, Blake M. Hauser, David M. Meredith, Ian F. Dunn, Wenya Linda Bi   +6 more
doaj   +1 more source

Spatially Resolved Multiomics Reveals Metabolic Remodeling and Autophagy Activation in Adamantinomatous Craniopharyngiomas

Advanced Science, EarlyView.
Multiomics integration analysis reveals the “cystic fluid–tumor cell” metabolic coupling that mediates active choline/ethanolamine uptake of tumor cells from cystic fluid and PC/PE synthesis pathways reprogramming that mediating autophagy pathway activation within ACP. ABSTRACT Adamantinomatous craniopharyngioma (ACP), a benign yet highly recurrent and
Dongting Chen, Yahui Gao, Yulin Wang, Ting Lei, Zheng Qu, Yuhan An, Jiaxu Fu, Xin Li, Fangjun Liu, Yan Li   +9 more
wiley   +1 more source

Hypothalamic-pituitary-gonadal axis disturbance and its association with insulin resistance in kidney transplant recipients [PDF]

, 2022
Lourdes Balcázar‐Hernández, Victoria Mendoza‐Zubieta, Baldomero González‐Virla, Brenda González-García, Mariana Osorio-Olvera, Jesús Ubaldo Peñaloza-Juárez, Irene Irisson-Mora, Martha Cruz-López, Raúl Rodríguez-Gómez, Ramón Espinoza-Pérez, Guadalupe Vargas‐Ortega   +10 more
openalex   +1 more source

Comparative Single‐Cell Transcriptomic Atlas Reveals the Genetic Regulation of Reproductive Traits

Advanced Science, EarlyView.
A cross‐species single‐cell transcriptomic atlas of reproductive and central nervous system tissues from sheep and humans reveals conserved cellular programs and regulatory networks that regulated fertility. Integration with GWAS for sheep lifetime average litter size identifies UNC5–SLIT–BMP signaling as a core pathway coordinating neuroendocrine ...
Bingru Zhao, Hanpeng Luo, Dailu Guan, Xuefeng Fu, Feng Wang, Guoming Zhang, Shanglai Li, Hua Yang, Yanli Zhang   +8 more
wiley   +1 more source

Identifying Facial Features and Predicting Patients of Acromegaly Using Three-Dimensional Imaging Techniques and Machine Learning

Frontiers in Endocrinology, 2020
Objective: Facial changes are common among nearly all acromegalic patients. As they develop slowly, patients often fail to notice such changes before they become obvious. Consequently, diagnosis and treatment are often delayed.
Tian Meng, Xiaopeng Guo, Xiaopeng Guo, Xiaopeng Guo, Wei Lian, Wei Lian, Wei Lian, Kan Deng, Kan Deng, Kan Deng, Lu Gao, Lu Gao, Lu Gao, Zihao Wang, Zihao Wang, Zihao Wang, Jiuzuo Huang, Xiaojun Wang, Xiao Long, Bing Xing, Bing Xing, Bing Xing   +21 more
doaj   +1 more source

AXL Promotes Ischemic Myelin Repair Through Alleviating Myelin Debris Deposition and Lipid Droplets Accumulation

Advanced Science, EarlyView.
Microglial AXL drives white matter repair after stroke by orchestrating the cleanup of myelin debris. Mechanistically, AXL signals through EGR1 to boost Smpd1 transcription, regulating sphingolipid metabolism and preventing lipid droplet toxicity. Restoring the pathway with ASM therapy mitigates damage, positioning AXL as a key node for therapeutic ...
Junqiu Jia, Yonghui Gan, Jia Li, Lilin Li, Hailan Meng, Min Sun, Lei Ye, Rui Mao, Xiang Cao, Shengnan Xia, Xinyu Bao, Renyuan Liu, Meijuan Zhang, Yun Xu   +13 more
wiley   +1 more source

Multi‐Tissue Genetic Regulation of RNA Editing in Pigs

Advanced Science, EarlyView.
This study presents the first multi‐tissue map of RNA editing and its genetic regulation in pigs. By integrating RNA editing profiles, edQTL mapping, GWAS, and cross‐species comparisons, this work establishes RNA editing as a distinct regulatory layer linking genetic variation to complex traits, highlighting its functional and evolutionary significance.
Xiangchun Pan, Wentao Gong, Xiaodian Cai, Jinyan Teng, Jiali Cai, Haonan Zeng, Wondossen Ayalew, Qingpeng Shen, Zhanming Zhong, Yifei Wang, Wenjing Zhang, Yuhan Tian, Dantong Xu, Yahui Gao, Hongwei Yin, Yuebo Zhang, Jiahui Hou, Tianru Zhou, Jiaqi Li, Lingzhao Fang, Xiaolong Yuan, Zhe Zhang   +21 more
wiley   +1 more source

Management of Intracranial Perforator Aneurysms

Stroke: Vascular and Interventional Neurology
Intracranial perforator aneurysms are rare but potentially life‐threatening vascular lesions that can lead to subarachnoid hemorrhage. Initial imaging is frequently negative, so a high level of suspicion is important for efficient detection of perforator
Karthik Papisetty, Sam J. Schulz, Rajiv Dharnipragada, Andrew S. Venteicher   +3 more
doaj   +1 more source

Educational Impact of Artificial Intelligence‐Navigation Surgery on Anatomical Landmark Recognition in Medical Students

Annals of Gastroenterological Surgery, EarlyView.
This study evaluated the educational impact of artificial intelligence (AI)‐navigation surgery that provides real‐time anatomical landmark recognition during laparoscopic cholecystectomy for medical students. Thirty students were randomized into surgeon‐guided, self‐learning, and AI‐learning groups, and their performance was assessed using Dice ...
Shigeo Ninomiya, Yusuke Matsunobu, Tabito Oyama, Hiroomi Takayama, Takashi Masuda, Teijiro Hirashita, Yuichi Endo, Tatsushi Tokuyasu, Masafumi Inomata   +8 more
wiley   +1 more source

3D Facial Analysis in Acromegaly: Gender-Specific Features and Clinical Correlations

Frontiers in Endocrinology, 2018
Objective: Quantitative investigations of facial changes in acromegaly are rare. A new imaging technique, three-dimensional (3D) stereophotography, can accurately quantify whole facial changes.
Xiaopeng Guo, Xiaopeng Guo, Xiaopeng Guo, Tian Meng, Jiuzuo Huang, Xiaojun Wang, Wei Lian, Wei Lian, Wei Lian, Kan Deng, Kan Deng, Kan Deng, Lu Gao, Lu Gao, Lu Gao, Zihao Wang, Zihao Wang, Zihao Wang, Bing Xing, Bing Xing, Bing Xing, Xiao Long   +21 more
doaj   +1 more source