Results 111 to 120 of about 62,608 (262)

Neurotrophic Signaling, Sleep Physiology, and Retinal Neuroprotection: Integrative Mechanisms and Therapeutic Implications for Glaucoma

Sensory Neuroscience, EarlyView.
Glaucoma is increasingly understood as a neurodegenerative disorder shaped by sleep and circadian physiology, not intraocular pressure alone. Sleep loss and obstructive sleep apnea suppress BDNF–TrkB neurotrophic signaling, impair sleep‐dependent glymphatic clearance, and trigger microglial neuroinflammation and vascular insult at the optic nerve head,
Karyme M. Alemán‐Villa, Emiliano Terán, Javier A. Magaña‐Gómez, Loranda Calderón‐Zamora, Beatriz K. De la Herrán‐Arita, Alberto K. De la Herrán‐Arita   +5 more
wiley   +1 more source

Impact of sleep insufficiency and recovery on cancer development

Sleep Research, EarlyView.
Abstract Sleep plays a critical role in overall health, and modern lifestyles, such as shift work and late‐night activities, can significantly impact sleep condition. Insufficient sleep has been associated with various adverse health outcomes, including an increased risk of tumor development.
Xiaxi Li, Chuanyuan Li, Yi Zhang
wiley   +1 more source

A Droplet‐Microarray Platform for Multiplex Profiling of Breast Cancer Exosome Subtypes in Patients’ Blood Plasma Samples

Small, EarlyView.
This study presents a droplet‐microarray platform integrated with a DNase I‐assisted MoS2 FRET aptasensor for multiplexed profiling of breast cancer subtypes’ exosomes from patients’ plasma. By targeting HER2, MUC1, and CD44, the system enables sensitive detection and accurate discrimination of luminal A, HER2‐positive, and triple‐negative subtypes ...
Yi Liu, Ruolin Zhang, Jialei Song, Meng Xiao, Yue Meng, Zhiyang Li, Jingyu Shi, Yunyan Tai, Bing Gu, Mo Yang   +9 more
wiley   +1 more source

Identification and Discrimination of Sulfated and Unsulfated Gut‐Hormone Biomarkers in Human Serum by Nanopore

Small, EarlyView.
This study discriminates between sulfated and unsulfated cholecystokinin‐8 gut‐hormone forms at single‐molecule‐level resolution. Using an aerolysin nanopore embedded in a hybrid lipid‐polymer membrane, the system produces distinct electrical signatures enabling highly sensitive detection, even in 20% human serum.
Luca Iesu, Laurent Bacri, Juan Pelta, Benjamin Cressiot   +3 more
wiley   +1 more source

Temozolomide in aggressive and metastatic pituitary tumors: a Brazilian multicenter real-world cohort study. [PDF]

Pituitary
de Magalhães IPA, de Macedo CRPB, Naves LA, Czepielewski MA, Rosa IN, de Santana LB, de Almeida TS, Padula M, Elias PCL, de Castro M, Kasuki L, Gadelha MR, Rech CGSL, Garmes HM, Boguszewski CL, Jallad RS, Nakaguma M, Fragoso MCBV, Machado MC, Glezer A, da Cunha Neto MBC, Feher O, Batista RL.   +22 more
europepmc   +1 more source

The 5T Paradox of Triclosan: From Toiletries to Toxic Trash, a Growing Threat to Humanity

Environmental Toxicology, EarlyView.
ABSTRACT Triclosan (TCS) persists as a contaminant of concern in the Anthropocene, despite regulatory actions. Environmental dissemination continues through wastewater effluents, biosolid application, and improper disposal practices. This narrative review synthesizes current evidence regarding triclosan's environmental fate, transformation pathways ...
Temitope Aribigbola, Mauro Ricardo Souza da Luz, Sunday Amos Onikanni, Marjorie Dardis Murucci, Oluwatosin Stella Olayinka, Rodrigo Soares Fortunato, Rômulo Sperduto Dezonne, Omolola Esther Amos, Sara Gemini Piperni, Denise Pires de Carvalho, Leandro Miranda‐Alves   +10 more
wiley   +1 more source

Microwave‐assisted one‐pot synthesis of MXene–rGO–Au nanocomposites for high‐sensitivity dopamine detection

VIEW, EarlyView.
MXene/rGO/Au nanocomposites on a modified glassy carbon electrode enable rapid, sensitive DA detection with strong selectivity and reliable real‐sample recovery. The one‐pot microwave synthesis delivers a conductive, high‐performance platform for practical electrochemical DA sensing.
Farah Ezzah Ab Latif, Arshid Numan, Norhuda Abdul Manaf, Mohammad Khalid, Nabisab Mujawar Mubarak, Haizum Aimi Zaharin, Nilay Shah   +6 more
wiley   +1 more source

A Recurrent Tympanicum Paraganglioma With a SDHD Pathogenic Variant: Fourth Reported Case

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective The aim of this study is to describe a clinical case of a SDHD germline mutation associated tympanic paraganglioma (TPGL). Patients A female patient seen in the otology clinic at a tertiary care center with a diagnosis of tympanic paraganglioma and significant family history of head and neck paragangliomas.
Alex Z. Graboyes, Kevin Wong, Yonghong Huan, Jason A. Brant   +3 more
wiley   +1 more source

Application and Outcomes of Indocyanine Green in Endoscopic Transsphenoidal Surgery for Functional Pituitary Tumors: A Literature Review. [PDF]

Brain Sci
Habes M, Lang DK, Khairy S, Vargas-Moreno A, Rabski J, Kilty SJ, AlKherayf F.   +6 more
europepmc   +1 more source

Targeting Autophagy for Pituitary Tumors. [PDF]

Cancers (Basel)
Yin E, Satou M, Tateno T.
europepmc   +1 more source