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Changes in PKM2 Associate with Prostate Cancer Progression
Cancer Investigation, 2014Pyruvate kinase M2 (PKM2) is essential for aerobic glycolysis, the dominant metabolic pathway utilized by cancer cells. To determine the association of PKM2 with prostate cancer (PC), we examined 29 primary PC and three lymph node metastatic tumors; elevation of PKM2 was observed in Gleason 8-10 tumors compared to Gleason 6-7 carcinomas.
Jason De Melo +5 more
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The potential roles of PKM2 in cerebrovascular diseases
International ImmunopharmacologyPyruvate kinase M2 (PKM2), a key enzyme involved in glycolysis,plays an important role in regulating cell metabolism and growth under different physiological conditions. PKM2 has been intensively investigated in multiple cancer diseases. Recent years, many studies have found its pivotal role in cerebrovascular diseases (CeVDs), the disturbances in ...
Ling, Ma +3 more
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PKM2-induced protection from hyperglycaemia
Nature Reviews Nephrology, 2022openaire +2 more sources
Development of selective PKM2 and PARP1 inhibitors
The aim of the project is to find novel selenium-containing anticancer drug candidates in the Unmet Medical Need category. The starting point for the project is our recently discovered hit compound, a selective pyruvate kinase M2 (PKM2) (IC50 = 350 nM) and poly(ADP-ribose)polymerase-1 (PARP1) (IC50 = 250 nM) inhibitor.openaire +1 more source