Results 131 to 140 of about 22,457 (246)

Changes of Serum Pyruvate Kinase M2 Level in Patients with Sepsis and Its Clinical Value

Infection and Drug Resistance, 2023
Li Wang, Dongling Tang, Pingan Zhang Department of Clinical Laboratory, Institute of Translational Medicine, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, People’s Republic of ChinaCorrespondence: Pingan Zhang, Department of Clinical ...
Wang L, Tang D, Zhang P
doaj  

KAT2A Deficiency Suppresses Lung Cancer Progression by Downregulating MYC Through Decreasing MYC Succinylation

Cancer Science, EarlyView.
ABSTRACT Succinylation has been shown to promote lung cancer development, but its mechanism remains incompletely understood. KAT2A, a succinyltransferase, acts as an oncogene in multiple cancers, but its role in mediating lung cancer progression is unclear.
Junping Li, Feng Zhao, Zhongchao Wang, Shaojun Yang, Zhichao Lu, Xiaoyan Li, Jincheng Song, Zhaoxia Dai   +7 more
wiley   +1 more source

PHGDH Orchestrates Cell Cycle Progression to Drive Cardiomyocyte Proliferation and Myocardial Regeneration via TGF‐β/Smad Signalling Pathway

Cell Proliferation, EarlyView.
PHGDH promoted cardiomyocyte proliferation and myocardial regeneration via cell cycle and TGF‐β/Smad signalling pathways during cardiac repair. Moreover, PHGDH benefits cardiac repair and cardiomyocyte proliferation in mammalian mice following MI. ABSTRACT The mature mammalian heart has limited ability for self‐repair and regeneration.
Han Zhang, Li Zhang, Zehao Feng, Xing Li, Zhaohui Qiu, Xingyun Wang, Lingmei Qian   +6 more
wiley   +1 more source

OSA Initiates Histone Lactylation That Drives PDE4B/FUS/AGT Axis to Pulmonary Hypertension

Cell Proliferation, EarlyView.
This study illustrates how chronic intermittent hypoxia (CIH) in obstructive sleep apnea (OSA) leads to hypertension via increased oxidative stress and mitochondrial dysfunction in pulmonary artery smooth muscle cells (PASMCs), causing glycolytic dysregulation. Lactate accumulation enhances histone lactylation, upregulating phosphodiesterase 4B (PDE4B),
Li Yang, Qing Ni, Yan He, Shijie Liu, Lulu Gan, Anni Dai, Yang Hu, Qian Liu, Xueling Yang, Jiqian Li, Yi Tao, Yunyu Li, Mingyue Xu   +12 more
wiley   +1 more source

Signal Transducer and Activator of Transcription (STAT) Proteins Regulate Mucosal‐Associated Invariant T (MAIT) Cell Function

Immunology, EarlyView.
Integrated transcriptomic, proteomic and flow cytometry analyses reveal that STAT1 negatively regulates MAIT cell effector and glycolytic functions, while STAT3, STAT5 and HIF1α act as positive modulators. Targeting these pathways may offer new strategies to restore MAIT cell function in immune dysregulation and cancer.
Olivia J. Cheng, Eimear K. Ryan, Michael Bennett, Christy Clutter, Jackson G. Cacioppo, Jeffrey Aubé, Andy E. Hogan, Daniel T. Leung   +7 more
wiley   +1 more source

PKM2 promotes lymphatic metastasis of hypopharyngeal carcinoma via regulating epithelial-mesenchymal transition: an experimental research

Diagnostic Pathology
Background Patients with hypopharyngeal carcinoma (HPC) have a poor prognosis mainly because of lymphatic metastasis. This research aimed to determine the PKM2 role in lymphatic metastasis in HPC and the underlying molecular mechanism contributing to ...
Xin Zhou, Yanshi Li, Min Pan, Tao Lu, Chuan Liu, Zhihai Wang, Fengxiang Tang, Guohua Hu   +7 more
doaj   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

Tumor M2-PK: A novel urine marker of bladder cancer.

PLoS ONE, 2019
PurposeBladder cancer is a "Warburg-like" tumor characterized by a reliance on aerobic glycolysis and expression of pyruvate kinase M2 (PKM2). PKM2 oscillates between an active tetramer and an inactive dimer.
Weiya Liu, Benjamin L Woolbright, Karim Pirani, Ryan Didde, Erika Abbott, Gaurav Kaushik, Paige Martin, Jill Hamilton-Reeves, John A Taylor, Jeffrey M Holzbeierlein, Shrikant Anant, Eugene K Lee   +11 more
doaj   +1 more source

Circ_0098181 binds PKM2 to attenuate liver fibrosis

Frontiers in Pharmacology
BackgroundLiver cirrhosis seriously harms human health and fibrosis is the essential pathological process of cirrhosis. Recently, circular RNAs (circRNAs) were found to play critical roles in liver fibrosis, but the key circRNAs and precise mechanisms remained unclear.
Yuan-Yuan Luo, Ya-Ping Guan, Hong-Fei Zhan, Chun-Yan Sun, Ling-Yan Cai, Ke-Gong Tao, Yong Lin, Xin Zeng   +7 more
openaire   +3 more sources

Targeting aerobic glycolysis combats tyrosine kinase inhibitor resistance of hepatocellular carcinoma

International Journal of Cancer, Volume 158, Issue 3, Page 475-487, 1 February 2026.
Abstract Hepatocellular carcinoma (HCC) represents the predominant form of primary liver cancer and is frequently identified at a late stage, necessitating systemic therapy. However, resistance to first‐line tyrosine kinase inhibitor therapies, such as sorafenib and lenvatinib, remains a significant clinical challenge.
Longtao Zhao, Junjie Cheng, Yiming Zheng, Jing Wu, Jia Fan, Haixiang Sun, Chao Gao   +6 more
wiley   +1 more source