Results 141 to 150 of about 18,059 (264)

The PKM2/HIF-1α Axis is Involved in the Pathogenesis of Endometriosis via TGF-β1 under Endometrial Polyps

Frontiers in Bioscience-Landmark
Background: Endometriosis patients exhibit a cancer-like glycolytic phenotype. The pyruvate kinase M2 (PKM2)/hypoxia-inducible factor-1 alpha (HIF-1α) axis plays important roles in glycolysis-related diseases, but its role in patients ...
Jianjuan Li, Li Liu, Ruiqi Fan
doaj   +1 more source

Emerging roles of PKM2 in cell metabolism and cancer progression [PDF]

, 2012
Weibo Luo, Gregg L. Semenza
openalex   +1 more source

Oxidative Stress: Signaling Pathways, Biological Functions, and Disease

MedComm, Volume 6, Issue 7, July 2025.
Oxidative stress causes cellular damage across multiple systems, contributing to neurodegeneration (Alzheimer's, Parkinson's, Huntington's), cancer progression and resistance, cardiovascular diseases (atherosclerosis, heart failure), liver and kidney injury, metabolic disorders (diabetes, obesity), autoimmune diseases, musculoskeletal decline, retinal ...
Sixuan Liu, Jiachen Liu, Yinhuai Wang, Fei Deng, Zebin Deng   +4 more
wiley   +1 more source

CircRNA-0013747 Promotes Mesangial Cell Proliferation in Immunoglobulin A Nephropathy through Modulation of the Warburg Effect

Journal of Physiological Investigation
Immunoglobulin A nephropathy (IgAN) is characterized by aberrant mesangial cell (MC) proliferation, which is a critical determinant of glomerular sclerosis and renal dysfunction.
Huimei Zou, Wenli Deng, Lifen Xu, Mingjun Shi, Lingling Liu, Lei Gong, Daolin Cui, Fan Zhang   +7 more
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Erratum: ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect [PDF]

, 2012
Weiwei Yang, Yanhua Zheng, Yan Xia, Haitao Ji, Xiaohong Chen, Fang Guo, Costas A. Lyssiotis, Kenneth Aldape, Lewis C. Cantley, Zhimin Lu   +9 more
openalex   +1 more source

Lactate Metabolism and Lactylation Modification: New Opportunities and Challenges in Cardiovascular Disease

MedComm, Volume 6, Issue 7, July 2025.
Lactate, beyond a metabolic byproduct, regulates immunity and inflammation, linked to cardiovascular diseases (CVD) via metabolic reprogramming. Lactylation, a lactate‐driven epigenetic mark, modulates gene expression in fibrosis, lipid disorders, and CVD progression.
Mengyang Song, Bin Liu, Haiou Wang, Wei Sun   +3 more
wiley   +1 more source

PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells [PDF]

, 2013
William J. Israelsen, Talya L. Dayton, Shawn M. Davidson, Brian P. Fiske, Aaron M. Hosios, Gary Bellinger, Jie Li, Yimin Yu, Mika Sasaki, James W. Horner, Laura N. Burga, Jianxin Xie, Michael J. Jurczak, Ronald A. DePinho, Clary B. Clish, Tyler Jacks, Richard G. Kibbey, Gerburg M. Wulf, Dolores Di Vizio, Gordon B. Mills, Lewis C. Cantley, Matthew G. Vander Heiden   +21 more
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Aging‐Associated Vacuolation of Multi‐Ciliated Cells in the Distal Mouse Oviduct Reflects Unique Cell Identity and Luminal Microenvironment

Aging Cell, Volume 24, Issue 7, July 2025.
Multi‐ciliated cells in the infundibulum and ampulla (INF/AMP) epithelium are vacuolated in aging. Unique cellular susceptibility of the INF/AMP epithelial population and aging‐associated decline in ovarian artery circulation, which supports the ovary and INF/AMP, contribute to this region‐specific vacuolation phenotype, as a consequence of a mildly ...
Keerthana Harwalkar, Nobuko Yamanaka, Alain S. Pacis, Selina Zhao, Katie Teng, Warwick Pitman, Mitaali Taskar, Vera Lynn, Alex Frances Thornton, Matthew J. Ford, Yojiro Yamanaka   +10 more
wiley   +1 more source

PTBP1 and Cancer: From RNA Regulation to Therapeutic Potential

Journal of Cellular and Molecular Medicine, Volume 29, Issue 13, July 2025.
ABSTRACT Polypyrimidine tract binding protein 1 (PTBP1) belongs to the heterogeneous nuclear ribonucleoprotein (hnRNP) family and is a widely studied RNA‐binding protein involved in regulating mRNA splicing, stability, localization, and translation. In addition, PTBP1 can participate in various non‐coding RNA action processes and affect tumorigenesis ...
Chengdong Ji, Jing Zhu, Xiaochen Hou, Chen Zhou, Jiumei Zhao, Xiang Zheng, Yu Tang   +6 more
wiley   +1 more source

Dihydroartemisinin Inhibits the Proliferation of Leukemia Cells K562 by Suppressing PKM2 and GLUT1 Mediated Aerobic Glycolysis

Drug Design, Development and Therapy, 2020
Peng Gao,1,2 Shuo Shen,1,2 Xiaodong Li,3 Dandan Liu,1,2 Yuqing Meng,1,2 Yanqing Liu,1,2 Yongping Zhu,1,2 Junzhe Zhang,1,2 Piao Luo,1,2 Liwei Gu1,2 1Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, People ...
Gao P, Shen S, Li X, Liu D, Meng Y, Liu Y, Zhu Y, Zhang J, Luo P, Gu L   +9 more
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