Results 141 to 150 of about 24,169 (302)
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Proteasome 26S subunit non‐ATPase 14 (PSMD14) plays a pro‐carcinogenic role in various cancers. However, its specific effects and mechanisms in pancreatic cancer (PC) remain unclear. We aimed to assess the function and mechanism of PSMD14 in PC.
Yun‐He Hao +3 more
wiley +1 more source
Mass Spectrometry Structural Proteomics Enabled by Limited Proteolysis and Cross‐Linking
Mass Spectrometry Reviews, EarlyView.ABSTRACT The exploration of protein structure and function stands at the forefront of life science and represents an ever‐expanding focus in the development of proteomics. As mass spectrometry (MS) offers readout of protein conformational changes at both the protein and peptide levels, MS‐based structural proteomics is making significant strides in the
Haiyan Lu +4 more
wiley +1 more source
Changes of Serum Pyruvate Kinase M2 Level in Patients with Sepsis and Its Clinical Value
Infection and Drug Resistance, 2023 Li Wang, Dongling Tang, Pingan Zhang Department of Clinical Laboratory, Institute of Translational Medicine, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, People’s Republic of ChinaCorrespondence: Pingan Zhang, Department of Clinical ...
Wang L, Tang D, Zhang P
doaj
Pyruvate kinase M2 (PKM2), a glycolytic enzyme, is required to maintain vascular barrier function [PDF]
, 2017 RATIONALE - Metabolic enzymes, like pyruvate kinase M2 (PKM2), play an essential role in altering endothelial cell (EC) phenotypes and behavior. Extensive research has elucidated the function of PKM2, a rate-limiting glycolytic enzyme, in the context of ...
Dharaneeswaran, Harita
core
No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis [PDF]
, 2011 The Warburg effect describes the circumstance that tumor cells preferentially use glycolysis rather than oxidative phosphorylation for energy production.
Bluemlein, Katharina +5 more
core +2 more sources
The role of gut microbiota‐derived metabolites in neuroinflammation
Neuroprotection, EarlyView.Gut microbiota‐derived metabolites accumulate in the brain, activating or inhibiting microglia and astrocytes, which affects neuroinflammatory progression. The gut microbiota converts the diet into a variety of metabolites, including bile acid, trimethylamine N‑oxide (TMAO), and indole.
Lingjie Mu, Yijie Wang
wiley +1 more source
PKM2 Promotes Breast Cancer Progression by Regulating Epithelial Mesenchymal Transition
Analytical Cellular Pathology, 2020 Breast cancer is the leading cause of females characterized by high invasive potential. It is necessary to explore the underlying mechanism of breast cancer metastases and to find specific therapeutic targets. PKM2 is considered a new biomarker of cancer
Hui Xiao +6 more
doaj +1 more source
Metabolic reprogramming identifies the most aggressive lesions at early phases of hepatic carcinogenesis [PDF]
, 2016 Metabolic changes are associated with cancer, but whether they are just bystander effects of deregulated oncogenic signaling pathways or characterize early phases of tumorigenesis remains unclear.
Angioni, Maria Maddalena +16 more
core +3 more sources
IGF1 regulates PKM2 function through Akt phosphorylation [PDF]
Cell Cycle, 2015 Pyruvate kinase M2 (PKM2) acts at the crossroad of growth and metabolism pathways in cells. PKM2 regulation by growth factors can redirect glycolytic intermediates into key biosynthetic pathway. Here we show that IGF1 can regulate glycolysis rate, stimulate PKM2 Ser/Thr phosphorylation and decrease cellular pyruvate kinase activity. Upon IGF1 treatment
Barbara Salani a +18 more
openaire +4 more sources
Aging Cell, EarlyView.Multi‐ciliated cells in the infundibulum and ampulla (INF/AMP) epithelium are vacuolated in aging. Unique cellular susceptibility of the INF/AMP epithelial population and aging‐associated decline in ovarian artery circulation, which supports the ovary and INF/AMP, contribute to this region‐specific vacuolation phenotype, as a consequence of a mildly ...
Keerthana Harwalkar +10 more
wiley +1 more source