Results 161 to 170 of about 24,169 (302)

PKM2 Expression and Elevated CD163 in Macrophage Synergistically Promote Osteosarcoma Progression

Zhongliu Fangzhi Yanjiu, 2019
Objective To investigate the relation between PKM2 and related pathological features of osteosarcoma, to further explore the markers for predicting the prognosis of osteosarcoma patients.
TAN Wenfu, YANG Juntao, XIA Xue, XIANG Renkun, WANG Xiaoxu   +4 more
doaj   +1 more source

Functional consequence of PSAT1 association on PKM2\u27s inherent enzymatic activity. [PDF]

, 2018
Pyruvate kinase M2 (PKM2) is predominantly found in tumors, where it allows the cancer cell to adapt to metabolic conditions through allosteric regulation of its activity.
Vega, Alexis Avidan
core   +1 more source

Molecular association of glucose-6- phosphate isomerase and pyruvate kinase M2 with glyceraldehyde-3-phosphate dehydrogenase in cancer cells [PDF]

, 2016
Background: For a long time cancer cells are known for increased uptake of glucose and its metabolization through glycolysis. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a key regulatory enzyme of this pathway and can produce ATP through ...
A Sawa, Alok Ghosh, Arup K. Bag, AT Cordeiro, B Khatua, B You, C Tristan, Chitra Mandal, D Anastasiou, D Kozakov, D Kozakov, D Schneidman-Duhovny, D Wang, DE Epner, E Krissinel, EJ Tisdale, F Ferreira-da-Silva, H Nakajima, HM Berman, HR Christofk, JH Roe, JJ Laschet, JL Jenkins, K Tokunaga, M Cortés-Cros, M Ray, M Torchala, Mahua R. Das, Manju Ray, N Schek, O Warburg, PA Saunders, PE Glaser, Provas Das, Q Huang, Q Zhang, RA Gomes, RE Ferguson, S Bagui, S Carujo, S Mazurek, S Patra, S Ray, S Saha, S Saha, Saikat Chakrabarti, Shekhar Saha, Siddhartha S. Jana, Subhankar Ray, Sumit K. Dey, T Funasaka, T Funasaka, T Li, T Noguchi, V Ravichandran, W Luo, W Yang, W Yang, X Gao   +58 more
core   +1 more source

Emerging pathological diagnostic strategies for solid pseudopapillary neoplasm of the pancreas: insights from omics and innovative techniques

The Journal of Pathology: Clinical Research, Volume 11, Issue 3, May 2025.
Abstract Solid pseudopapillary neoplasm (SPN) of the pancreas is a rare, low‐grade malignant tumor, representing 0.9–2.7% of all exocrine pancreatic tumors. SPN patients generally have a favorable prognosis with a 5‐year survival rate exceeding 95% following complete surgical resection.
Yuanhao Liu, Junya Peng, Yupei Zhao, Wenze Wang   +3 more
wiley   +1 more source

The Activation of PKM2 Induces Pyroptosis in Hippocampal Neurons via the NLRP3/Caspase‐1/GSDMD Pathway in Neonatal Rats With Hypoxic‐Ischemic Brain Injury

Brain and Behavior
Introduction The presence of hypoxic‐ischemic brain damage (HIBD) in neonates triggers a strong neuroinflammatory reaction. Pyroptosis, a programmed cell death mechanism associated with inflammation, plays a crucial role in HIBD. Pyruvate kinase M2 (PKM2)
Sha Sha, Ni Jin, Ruiyu Zhou, Yanghao Ruan, Ying Ouyang   +4 more
doaj   +1 more source

Oxymatrine Inhibits Colorectal Cancer Metastasis via Attenuating PKM2-Mediated Aerobic Glycolysis

Cancer Management and Research, 2020
Xiaoping Li,1 Jie Sun,2 Qinghua Xu,1 Weiping Duan,2 Licheng Yang,1 Xing Wu,1 Guang Lu,1 Li Zhang,1 Yunfeng Zheng2 1Department of General Surgery, Liyang People′s Hospital, Jiangsu 213300, People’s Republic of China; 2School of Pharmacy ...
Li X, Sun J, Xu Q, Duan W, Yang L, Wu X, Lu G, Zhang L, Zheng Y   +8 more
doaj  

PET imaging of tumor glycolysis downstream of hexokinase through noninvasive measurement of pyruvate kinase M2 [PDF]

, 2015
Cancer cells reprogram their metabolism to meet increased biosynthetic demands, commensurate with elevated rates of replication. Pyruvate kinase M2 (PKM2) catalyzes the final and rate-limiting step in tumor glycolysis, controlling the balance between ...
Arksey, N, Bodapati, D, Chang, E, Chin, FT, Gambhir, SS, Gowrishankar, G, Hoehne, A, James, ML, Park, JH, Pohling, C, Rao, J, Shen, B, Shuhendler, A, Weber, J, Witney, TH   +14 more
core   +3 more sources

AKT1 Phosphorylates FDX1 to Promote Cuproptosis Resistance in Triple‐Negative Breast Cancer

Advanced Science, Volume 12, Issue 17, May 8, 2025.
This study demonstrates that copper activates the AKT signaling pathway, which inhibits ferredoxin‐1 (FDX1), a key regulator of cuproptosis. AKT1‐mediated FDX1 phosphorylation not only abrogates FDX1‐induced cuproptosis and aerobic respiration but also promotes glycolysis.
Zicheng Sun, Huazhen Xu, Guanming Lu, Ciqiu Yang, Xinya Gao, Jing Zhang, Xin Liu, Yongcheng Chen, Kun Wang, Jianping Guo, Jie Li   +10 more
wiley   +1 more source

PKM2 promotes lymphatic metastasis of hypopharyngeal carcinoma via regulating epithelial-mesenchymal transition: an experimental research

Diagnostic Pathology
Background Patients with hypopharyngeal carcinoma (HPC) have a poor prognosis mainly because of lymphatic metastasis. This research aimed to determine the PKM2 role in lymphatic metastasis in HPC and the underlying molecular mechanism contributing to ...
Xin Zhou, Yanshi Li, Min Pan, Tao Lu, Chuan Liu, Zhihai Wang, Fengxiang Tang, Guohua Hu   +7 more
doaj   +1 more source

Pyruvate kinase M2 inhibits cisplatin induced caspase-dependent apoptosis via ERK-mediated signaling pathway in hepatocellular carcinoma cells [PDF]

, 2016
M2型丙酮酸激酶（pyruvatekinaseisoenzymetypeM2，PKM2）在肿瘤代谢 和生长等方面发挥重要作用。此外，PKM2还可作为蛋白激酶及辅助转录因子， 调控相关基因的转录表达，促进肿瘤细胞的增殖。我们实验室前期已经证实了 PKM2在肝细胞癌中高表达，并通过EGF/EGFR及TGFβ/TGFβR信号通路调控 肝癌细胞的迁移、侵袭。本课题研究目的在于进一步探索PKM2在肝癌细胞增 殖与凋亡方面的调控作用及相关分子生物学机制。 采用短发夹RNA转染HepG2和Huh7两株肝癌细胞株 ...
谌小春
core