Results 61 to 70 of about 9,314 (134)

Silencing of PKM2 promotes Fas-Dependent Apoptosis via P53 -Mediated in Gastric cancer Cells [PDF]

, 2015
背景和目的：PKM2作为丙酮酸激酶（pyruvatekinaseisoenzyme，PK）家族成员，在肿瘤中呈现高表达，并且在肿瘤能量代谢过程中起到关键作用。近期研究发现，PKM2还具备转录因子活性，参与调控细胞增殖与迁移侵袭，在恶性肿瘤的发生发展中发挥重要作用。我们研究发现，胃癌细胞株BGC823及AGS中基因沉默PKM2后，促进了顺铂诱导的细胞凋亡，由此表明PKM2可以减低胃癌细胞对化疗药物的敏感性，但具体机制有待探索 ...
宋俊娇
core  

2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase [PDF]

, 2011
Compared to normal differentiated cells, cancer cells have altered metabolic regulation to support biosynthesis and the expression of the M2 isozyme of pyruvate kinase (PKM2) plays an important role in this anabolic metabolism.
Auld, Douglas S., Bougie, James M., Boxer, Matthew B., Brimacombe, Kyle R., Cantley, Lewis C., Daniel, Thomas, Israelsen, William James, Leister, William, Shen, Min, Thomas, Craig J., Vander Heiden, Matthew G., Veith, Henrike, Walsh, Martin J.   +12 more
core   +1 more source

One-carbon metabolism in cancer [PDF]

, 2017
Cells require one-carbon units for nucleotide synthesis, methylation and reductive metabolism, and these pathways support the high proliferative rate of cancer cells.
AJ MacFarlane, Alice C Newman, AS Tibbetts, B Chaneton, BC Blount, C Commisso, CA Lewis, CF Labuschagne, CF Woeller, D Hanahan, D Hanahan, D Kim, DD Anderson, E Currie, E Mullarky, F Daidone, F Kottakis, G Kikuchi, GM DeNicola, Gregory S. Ducker, GS Ducker, J Liu, J Meiser, J Ye, Jason W. Locasale, JJ Kamphorst, JW Locasale, K Snell, K Snell, K Snell, Katherine R. Mattaini, L Galluzzi, M Goulian, M Jain, M Kulis, Mahya Mehrmohamadi, ME Pacold, Ming Yang, MJ Osborn, ML Rose, ML Rose, OD Maddocks, OD Maddocks, Oliver D K Maddocks, Oliver D. K. Maddocks, PM Ueland, R Possemato, S Farber, S Kit, S Pollari, SJ Mentch, Swetha Bolusani, T Shlomi, WC Zhang, Y Fu, Z Ser   +55 more
core   +1 more source

Cancer Cell Metabolism: One Hallmark, Many Faces [PDF]

, 2012
Cancer cells must rewire cellular metabolism to satisfy the demands of growth and proliferation. Although many of the metabolic alterations are largely similar to those in normal proliferating cells, they are aberrantly driven in cancer by a combination ...
Cantor, Jason R., Sabatini, David
core   +2 more sources

Viral hijacking of cellular metabolism. [PDF]

, 2019
This review discusses the current state of the viral metabolism field and gaps in knowledge that will be important for future studies to investigate.
Ch'ng, James, Christofk, Heather R, Thaker, Shivani K   +2 more
core  

PKM2-mediated metabolic reprogramming of microglia in neuroinflammation

Cell Death Discovery
Abstract Microglia, the resident immune cells of the central nervous system, undergo metabolic reprogramming during neuroinflammation, playing a crucial role in the pathogenesis of neurological disorders such as Parkinson’s disease. This review focuses on Pyruvate Kinase M2 (PKM2), a key glycolytic enzyme, and its impact on microglial ...
Qi Zhang, Sha-Sha Wang, Zhao Zhang, Shi-Feng Chu   +3 more
openaire   +3 more sources

Metabolic reprogramming identifies the most aggressive lesions at early phases of hepatic carcinogenesis [PDF]

, 2016
Metabolic changes are associated with cancer, but whether they are just bystander effects of deregulated oncogenic signaling pathways or characterize early phases of tumorigenesis remains unclear.
Angioni, Maria Maddalena, Chiarugi, Paola, Columbano, Amedeo, Fornari, Francesca, Giordano, Silvia, Gramantieri, Laura, Guzzo, Giulia, Kowalik, Marta Anna, Ledda Columbano, Giovanna Maria, Masgras, Ionica, Menegon, Silvia, Morandi, Andrea, Perra, Andrea, Quagliata, Luca, Rasola, Andrea, Terracciano, Luigi, Trevisan, Elena   +16 more
core   +3 more sources

Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth [PDF]

, 2009
Taro Hitosugi, Sumin Kang, Matthew G. Vander Heiden, Tae‐Wook Chung, Shannon Elf, Katherine Lythgoe, Shaozhong Dong, Sagar Lonial, Xu Wang, Georgia Z. Chen, Jianxin Xie, Ting-Lei Gu, Roberto D. Polakiewicz, Johannes Roesel, Titus J. Boggon, Fadlo R. Khuri, D. Gary Gilliland, Lewis C. Cantley, Jonathan L. Kaufman, Jing Chen   +19 more
openalex   +1 more source

Impact of butyrate on PKM2 and HSP90β expression in human colon tissues of different transformation stages: a comparison of gene and protein data [PDF]

, 2011
Franziska Jahns, Anne Wilhelm, Karl Otto Greulich, Henning Mothes, Mariya Y. Radeva, Anja Wölfert, Michael Glei   +6 more
openalex   +1 more source

Emerging roles of PKM2 in cell metabolism and cancer progression [PDF]

, 2012
Weibo Luo, Gregg L. Semenza
openalex   +1 more source