Results 61 to 70 of about 22,457 (246)

PKM2 Nuclear Translocation Promotes Glial Cell Activation and Aggravates the Brain Injury of Intracerebral Hemorrhage

Journal of Integrative Neuroscience, 2023
Background: The purpose of this study was to investigate the potential involvement of pyruvate kinase M2 (PKM2), an enzyme acting as a rate-limiting enzyme in the final phase of glycolysis, in the regulation of glial activation and brain damage of ...
Xiao-Yi Xiong, Yan-Jing Liang, Xin-Xiao Zhang, Su-Hao Yang, Zhan-Qiong Zhong, Shu-Qing Liu, Jia-Yi Sun, Yong Tang, Shu-Guang Yu   +8 more
doaj   +1 more source

Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma [PDF]

, 2016
Alternative splicing of the Pkm gene product generates the PKM1 and PKM2 isoforms of pyruvate kinase (PK), and PKM2 expression is closely linked to embryogenesis, tissue regeneration, and cancer.
Bhutkar, Arjun, Bronson, Roderick T., Clish, Clary B., Davidson, Shawn Michael, Dayton, Talya L., Gocheva, Vasilena, Israelsen, William James, Jacks, Tyler E., Luengo, Alba, Miller, Kathryn, Vander Heiden, Matthew G.   +10 more
core   +1 more source

Hepatocyte‐Derived Extracellular Vesicles Deliver miR‐328‐3p to Trigger PP2A‐B56δ–Mediated p‐NLRP3S295‐Dependent Metaflammation in Macrophages upon Microcystin‐LR Exposure

Advanced Science, EarlyView.
Hepatocyte‐derived extracellular vesicles deliver miR‐328‐3p to trigger PP2A‐B56δ–mediated p‐NLRP3S295‐dependent metaflammation in macrophages upon microcystin‐LR exposure. 2‐DG, 2‐deoxy‐D‐glucose. B56δ, protein phosphatase 2A‐B56δ. ER, endoplasmic reticulum. iHD‐EV, inducible hepatocyte‐derived extracellular vesicles. IP3R, inositol 1,4,5‐triphosphate
Jia‐Shen Wu, Xin‐Yu Zhang, Xin‐Yu Ma, Yue‐Yue Wei, Lei‐Lei Wang, Ze‐Bang Du, Xiao‐Gang Xia, Lin Che, Dong‐Bei Guo, Han‐Ying Zheng, You‐Liang Yao, Wen‐Gang Li, Yu‐Chun Lin, Zhong‐Ning Lin   +13 more
wiley   +1 more source

PTDSS1 Drives Glycolysis and Malignant Progression of Lung Cancer Through Maintaining Nuclear–Mitochondrial Homeostatic Crosstalk

Frontiers in Bioscience-Landmark
Background: Phosphatidylserine synthase 1 (PTDSS1) is a crucial enzyme involved in phospholipid synthesis. However, its role in the metabolic regulation of lung cancer remains unclear.
Hailun Wang, Qiao Wang, Yandu He, Xuelu Pu, Yajun Li   +4 more
doaj   +1 more source

PARP14 promotes the warburg effect in hepatocellular carcinoma by inhibiting JNK1-dependent PKM2 phosphorylation and activation [PDF]

, 2015
Most tumour cells use aerobic glycolysis (the Warburg effect) to support anabolic growth and evade apoptosis. Intriguingly, the molecular mechanisms that link the Warburg effect with the suppression of apoptosis are not well understood.
A Barbarulo, AE Vaughn, AJ Levine, B Chaneton, C Bubici, CC Wong, CV Dang, D Anastasiou, D Anastasiou, D Beyoğlu, D Beyoğlu, DY Gui, E Kakazu, E Wurmbach, GK Abou-Alfa, H Ke, H Mohammed, H Shim, HJ Huber, HR Christofk, HR Christofk, JL Andersen, JS Boehm, K Bensaad, K Herzer, K Kitamura, K Wang, L Lv, L Lv, M Cortés-Cros, M Hatziapostolou, M Wiznerowicz, MG Vander Heiden, NM Grüning, NN Danial, P Chinnaiyan, P Mehrotra, Q Geissmann, R Koschny, R Ma, R Yang, RA Cairns, RA Gatenby, RG Jones, S Papa, SH Cho, SH Cho, SK McBrayer, SM Jang, SY Peng, T Amann, T Hitosugi, T Hitosugi, T Yamashita, T Yanagawa, TH Nguyen, V Schreiber, W Luo, W Yang, WJ Israelsen, Y Hoshida, Z Chen   +61 more
core   +2 more sources

Blocking Lysine Crotonylation and Aerobic Glycolysis as Targeting Strategy Against mpox Virus Replication

Advanced Science, EarlyView.
Wei et al. report that MPXV infection induces aerobic glycolysis, a process mediated by the viral protein I3 through lysine crotonylation at its K102 residue. The acetyltransferase MYST1 catalyzes the crotonylation of I3 to inhibit the ubiquitin‐mediated degradation of WDR26.
Pengjun Wei, Zongzheng Zhao, Ruoqi Xu, Qin Yan, Liangzi Jiang, Fuxiao Geng, Yang Gu, Tianjiao Wang, Jing Zhou, Xiao Li, Qin Yan, Chun Lu, Wan Li   +12 more
wiley   +1 more source

Long non-coding RNA SRA1 suppresses radiotherapy resistance in esophageal squamous cell carcinoma by modulating glycolytic reprogramming

Open Medicine
Esophageal squamous cell carcinoma (ESCC), a highly aggressive subtype of esophageal cancer, is characterized by late-stage diagnosis and limited treatment options.
Chen Yurao, Fan Peng, Chen Zhenhai, Zheng Zemao, He Ming, Zhao Xiang, Chen Ronghuai, Yao Juan, Yang Zhaodong   +8 more
doaj   +1 more source

Pyruvate kinase M2 is a poor prognostic marker of and a therapeutic target in ovarian cancer. [PDF]

PLoS ONE, 2017
Pyruvate kinase M2 (PKM2) regulates glycolysis and oxidative phosphorylation; however, the role of PKM2 in ovarian cancer remains largely unknown. We investigated whether ovarian cancer metabolism could provide insight into the development of therapeutic
Tai-Kuang Chao, Tien-Shuo Huang, Yu-Ping Liao, Rui-Lan Huang, Po-Hsuan Su, Hueng-Yuan Shen, Hung-Cheng Lai, Yu-Chi Wang   +7 more
doaj   +1 more source

PKM2, a Central Point of Regulation in Cancer Metabolism [PDF]

International Journal of Cell Biology, 2013
Aerobic glycolysis is the dominant metabolic pathway utilized by cancer cells, owing to its ability to divert glucose metabolites from ATP production towards the synthesis of cellular building blocks (nucleotides, amino acids, and lipids) to meet the demands of proliferation.
Nicholas Wong, Jason De Melo, Damu Tang
openaire   +3 more sources

FOXM1D potentiates PKM2‐mediated tumor glycolysis and angiogenesis [PDF]

Molecular Oncology, 2020
Tumor growth, especially in the late stage, requires adequate nutrients and rich vasculature, in which PKM2 plays a convergent role. It has been reported that PKM2, together with FOXM1D, is upregulated in late‐stage colorectal cancer and associated with metastasis; however, their underlying mechanism for promoting tumor progression remains elusive ...
Wei Zhang, Xin Zhang, Sheng Huang, Jianfeng Chen, Peipei Ding, Qi Wang, Luying Li, Xinyue Lv, Ling Li, Pingzhao Zhang, Danlei Zhou, Wenyu Wen, Yiping Wang, Qun‐Ying Lei, Jiong Wu, Weiguo Hu   +15 more
openaire   +4 more sources