Results 61 to 70 of about 18,059 (264)
PKM2 is a potential prognostic biomarker and related to immune infiltration in lung cancer
Scientific Reports, 2023 Pyruvate kinase M2 ( PKM2 ), a subtype of pyruvate kinase, plays a crucial role as a key enzyme in the final step of glycolysis. It is involved in regulating the tumor microenvironment and accelerating tumor progression. However, the relationship between
Lan Yin +8 more
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Please Keep Me 2uned to PKM2 [PDF]
Molecular Cell, 2014 In this issue of Molecular Cell, Keller et al. (2014) found that binding of the metabolite SAICAR to PKM2 induces the protein kinase activity of an enzyme normally designed to terminate the glycolytic pathway.
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JAK-STAT, 2012 The M2 isoform of pyruvate kinase, highly expressed in tumor cells, is known to engage a feed forward loop with the glycolysis master transcription factor HIF-1α. Gao and co-authors recently showed that dimeric PKM2 localizes to the nucleus in highly proliferating cancer cells, where it regulates in vivo growth by acting as a protein kinase and ...
DEMARIA, MARCO, POLI, Valeria
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PLoS ONE, 2019 Pyruvate kinase M2 (PKM2) is an alternatively spliced variant, which mediates the conversion of glucose to lactate in cancer cells under normoxic conditions, known as the Warburg effect.
Akiko Suzuki +7 more
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Journal of Inflammation, 2023 Background Delayed neutrophil apoptosis during sepsis may impact neutrophil organ accumulation and tissue immune homeostasis. Elucidating the mechanisms underlying neutrophil apoptosis may help identify potential therapeutic targets.
Yinjiao Li +8 more
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Cell Reports, 2017 LPS-activated macrophages undergo a metabolic shift from dependence on mitochondria-produced ATP to reliance on aerobic glycolysis, where PKM2 is a critical determinant.
Fang Wang +12 more
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Science-Business eXchange, 2013 Novartis has shown that the absence of pyruvate kinase M2 isozyme has no effect on cancer cell proliferation in mice, thus suggesting PKM2 inhibition alone might not be an effective strategy to stop tumor growth. Biotechs working on PKM2 modulators think it is too early to write off the target.
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Research progress on the role of PKM2 in the immune response
Frontiers in Immunology, 2022 Pyruvate kinase (PK) is a key enzyme that catalyzes the dephosphorylation of phosphoenolpyruvate (PEP) into pyruvate, and is responsible for the production of ATP during glycolysis. As another important isozyme of PK, pyruvate kinase M2 (PKM2) exists in cells with high levels of nucleic acid synthesis, such as normal proliferating cells (e.g ...
Chunyan Liu, Chenchen Liu, Rong Fu
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FOXM1D potentiates PKM2‐mediated tumor glycolysis and angiogenesis [PDF]
Molecular Oncology, 2020 Tumor growth, especially in the late stage, requires adequate nutrients and rich vasculature, in which PKM2 plays a convergent role. It has been reported that PKM2, together with FOXM1D, is upregulated in late‐stage colorectal cancer and associated with metastasis; however, their underlying mechanism for promoting tumor progression remains elusive ...
Wei Zhang +15 more
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BMC Cancer, 2018 Background Hepatocellular carcinoma (HCC) is a malignant tumor that threatens global human health. High PKM2 expression is widely reported in multiple cancers, especially in HCC.
Wen-Wen Lv +6 more
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