Results 1 to 10 of about 60,739 (253)

Inhibition of PKR by Viruses [PDF]

Frontiers in Microbiology, 2021
Cells respond to viral infections through sensors that detect non-self-molecules, and through effectors, which can have direct antiviral activities or adapt cell physiology to limit viral infection and propagation.
Teresa Cesaro, Thomas Michiels
doaj   +5 more sources

An ADAR1 dsRBD3-PKR kinase domain interaction on dsRNA inhibits PKR activation

Cell Reports
Summary: Adar null mutant mouse embryos die with aberrant double-stranded RNA (dsRNA)-driven interferon induction, and Adar Mavs double mutants, in which interferon induction is prevented, die soon after birth.
Ketty Sinigaglia, Anna Cherian, Qiupei Du, Valentina Lacovich, Dragana Vukić, Janka Melicherová, Pavla Linhartova, Lisa Zerad, Stanislav Stejskal, Radek Malik, Jan Prochazka, Nadège Bondurand, Radislav Sedláček, Mary A. O’Connell, Liam P. Keegan   +14 more
doaj   +4 more sources

PKR: A Kinase to Remember [PDF]

Frontiers in Molecular Neuroscience, 2019
Aging is a major risk factor for many diseases including metabolic syndrome, cancer, inflammation, and neurodegeneration. Identifying mechanistic common denominators underlying the impact of aging is essential for our fundamental understanding of age ...
Shunit Gal-Ben-Ari, I. Barrera, M. Ehrlich, K. Rosenblum   +3 more
semanticscholar   +4 more sources

PKR activity modulation by phosphomimetic mutations of serine residues located three aminoacids upstream of double-stranded RNA binding motifs

Scientific Reports, 2021
Eukaryotic translation initiation factor 2 alpha kinase 2 (EIF2AK2), better known as PKR, plays a key role in the response to viral infections and cellular homeostasis by regulating mRNA translation.
Teresa Cesaro, Yohei Hayashi, Fabian Borghese, Didier Vertommen, Fanny Wavreil, Thomas Michiels   +5 more
doaj   +2 more sources

Dystonia 16 (DYT16) mutations in PACT cause dysregulated PKR activation and eIF2α signaling leading to a compromised stress response

Neurobiology of Disease, 2020
Dystonia 16 (DYT16) is caused by mutations in PACT, the protein activator of interferon-induced double-stranded RNA-activated protein kinase (PKR). PKR regulates the integrated stress response (ISR) via phosphorylation of the translation initiation ...
Samuel B. Burnett, Lauren S. Vaughn, Nutan Sharma, Ronit Kulkarni, Rekha C. Patel   +4 more
doaj   +2 more sources

eIF2B as a Target for Viral Evasion of PKR-Mediated Translation Inhibition

mBio, 2020
RNA-activated protein kinase (PKR) is a major innate immune factor that senses viral double-stranded RNA (dsRNA) and phosphorylates eukaryotic initiation factor (eIF) 2α. Phosphorylation of the α subunit converts the eIF2αβγ complex into a stoichiometric
Jennifer Deborah Wuerth, Matthias Habjan, Markus Kainulainen, Besim Berisha, Damien Bertheloot, Giulio Superti-Furga, Andreas Pichlmair, Friedemann Weber   +7 more
doaj   +2 more sources

PKR involvement in Alzheimer’s disease [PDF]

Alzheimer's Research & Therapy, 2017
Brain lesions in Alzheimer’s disease (AD) are characterized by Aβ accumulation, neurofibrillary tangles, and synaptic and neuronal vanishing. According to the amyloid cascade hypothesis, Aβ1-42 oligomers could trigger a neurotoxic cascade with kinase ...
J. Hugon, François Mouton-Liger, J. Dumurgier, C. Paquet   +3 more
semanticscholar   +6 more sources

Inflammation kinase PKR phosphorylates α-synuclein and causes α-synuclein-dependent cell death

Neurobiology of Disease, 2018
Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy comprise a group of neurodegenerative diseases termed synucleinopathies. Synucleinopathie are, characterized by presence of inclusion bodies in degenerating brain cells which ...
Lasse Reimer, Louise Buur Vesterager, Cristine Betzer, Jin Zheng, Lærke Dalsgaard Nielsen, Rikke Hahn Kofoed, Louise Berkhoudt Lassen, Ulrik Bølcho, Søren Riis Paludan, Karina Fog, Poul Henning Jensen   +10 more
doaj   +2 more sources

KSHV inhibits stress granule formation by viral ORF57 blocking PKR activation.

PLoS Pathogens, 2017
TIA-1 positive stress granules (SG) represent the storage sites of stalled mRNAs and are often associated with the cellular antiviral response. In this report, we provide evidence that Kaposi's sarcoma-associated herpesvirus (KSHV) overcomes the host ...
Nishi R Sharma, Vladimir Majerciak, Michael J Kruhlak, Zhi-Ming Zheng   +3 more
doaj   +2 more sources

ADAR1p150 prevents MDA5 and PKR activation via distinct mechanisms to avert fatal autoinflammation.

Molecules and Cells, 2023
Effective immunity requires the innate immune system to distinguish foreign nucleic acids from cellular ones. Cellular double-stranded RNAs (dsRNAs) are edited by the RNA-editing enzyme ADAR1 to evade being recognized as viral dsRNA by cytoplasmic dsRNA ...
Shi-Bin Hu, Jacki E. Heraud-Farlow, Tao Sun, Zhen Liang, Ankita Goradia, Scott Taylor, Carl R. Walkley, Jin Billy Li   +7 more
semanticscholar   +2 more sources