Results 111 to 120 of about 60,739 (253)

LGP2 plays a critical role in sensitizing mda-5 to activation by double-stranded RNA. [PDF]

, 2013
The DExD/H box RNA helicases retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation associated gene-5 (mda-5) sense viral RNA in the cytoplasm of infected cells and activate signal transduction pathways that trigger the production of type I ...
A Komuro, A Peisley, A Pichlmair, A Pichlmair, AM Bruns, D Bamming, DA Pippig, DE Levy, DW Leung, G Lennon, H Kato, H Kato, IC Berke, IC Berke, J Andrejeva, K Childs, K Childs, Karen L. Mossman, Kay S. Childs, KS Childs, L Didcock, L Strahle, M Binder, M Schlee, M Yoneyama, MD Johnston, MJ Killip, N Masson, P King, R Marais, R Randall, Richard E. Randall, S Goodbourn, S Rothenfusser, Stephen Goodbourn, T Satoh, T Venkataraman, V Hornung, X Li, Y Kumagai, YM Loo, YM Loo   +41 more
core   +3 more sources

Gut microbiome‐derived metabolites show promise in cancer research and therapy

Interdisciplinary Medicine, EarlyView.
The metabolites produced by the gut microbiome, which are subject to regulation by multiple factors, play a pivotal role in the progression of various types of cancer. These metabolites not only function as potential biomarkers for the early detection and monitoring of tumor development, but also actively participate in cancer therapeutic processes ...
Kangjie Yang, Yifan Wang, Daolin Tang, Peilong Li, Lutao Du   +4 more
wiley   +1 more source

Cooperative role of PACT and ADAR1 in preventing aberrant PKR activation by self-derived double-stranded RNA

Nature Communications
Double-stranded RNAs (dsRNAs) produced during viral infections are recognized by the innate immune sensor protein kinase R (PKR), triggering a host translation shutoff that inhibits viral replication and propagation.
Lavanya Manjunath, Gisselle Santiago, Pedro Ortega, Ambrocio Sanchez, Sunwoo Oh, Alexander Garcia, Junyi Li, Dana Duong, Elodie Bournique, Alexis Bouin, Bert L. Semler, Dheva Setiaputra, Rémi Buisson   +12 more
doaj   +1 more source

Native tertiary structure and nucleoside modifications suppress tRNA's intrinsic ability to activate the innate immune sensor PKR. [PDF]

PLoS ONE, 2013
Interferon inducible protein kinase PKR is an essential component of innate immunity. It is activated by long stretches of dsRNA and provides the first line of host defense against pathogens by inhibiting translation initiation in the infected cell. Many
Subba Rao Nallagatla, Christie N Jones, Saikat Kumar B Ghosh, Suresh D Sharma, Craig E Cameron, Linda L Spremulli, Philip C Bevilacqua   +6 more
doaj   +1 more source

Hepatopulmonary syndrome as presentation of pediatric metabolic dysfunction‐associated steatohepatitis

JPGN Reports, EarlyView.
Abstract Childhood obesity is rising and leading to serious co‐morbidities, among which is metabolic dysfunction‐associated steatotic liver disease (MASLD) predisposing individuals to cirrhosis. We describe a young 11‐year‐old Hispanic male who presented with hepatopulmonary syndrome secondary to cirrhotic portal hypertension from metabolic dysfunction‐
Shruti Sakhuja, Stacey S. Beer, Kalyani R. Patel, Alexiss M. Williams, Nhu Thao Galvan, John A. Goss, Krupa R. Mysore   +6 more
wiley   +1 more source

Therapeutic targeting of the PI4K2A/PKR lysosome network is critical for misfolded protein clearance and survival in cancer cells

Oncogene, 2019
The role of RNA-dependent protein kinase R (PKR) and its association with misfolded protein expression in cancer cells are unclear. Herein we report that PKR regulates misfolded protein clearance by preventing it release through exosomes and promoting ...
A. Pataer, B. Ozpolat, R. Shao, N. Cashman, S. Plotkin, C. E. Samuel, Steven H. Lin, N. Kabil, Jing Wang, M. Majidi, B. Fang, J. Roth, A. Vaporciyan, I. Wistuba, M. Hung, S. Swisher   +15 more
semanticscholar   +1 more source

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

Stimulated hepatic stellate cell promotes progression of hepatocellular carcinoma due to protein kinase R activation.

PLoS ONE, 2019
Hepatic stellate cells (HSCs) were reported to promote the progression of hepatocellular carcinoma (HCC), however its mechanism is uncertain. We previously reported that protein kinase R (PKR) in hepatocytes regulated HCC proliferation. In this study, we
Yusuke Imai, Osamu Yoshida, Takao Watanabe, Atsushi Yukimoto, Yohei Koizumi, Yoshio Ikeda, Yoshio Tokumoto, Masashi Hirooka, Masanori Abe, Yoichi Hiasa   +9 more
doaj   +1 more source

Peritoneal dialysis in polycystic kidney disease patients

Bulletin de la Dialyse à Domicile, 2020
Introduction: Peritoneal dialysis (PD) in patients with polycystosis. Currently, it can be offered as a first-line treatment in these patients. The aim of our work is to analyse and compare the clinical and biological parameters, the evolution of ...
Hajar Benzouina, aziza guennoun, Naima ouzeddoun, Rabia Bayahia, Loubnna Benamar   +4 more
doaj   +1 more source

Low-Rank Matrices on Graphs: Generalized Recovery & Applications [PDF]

, 2016
Many real world datasets subsume a linear or non-linear low-rank structure in a very low-dimensional space. Unfortunately, one often has very little or no information about the geometry of the space, resulting in a highly under-determined recovery ...
Perraudin, Nathanael, Shahid, Nauman, Vandergheynst, Pierre   +2 more
core   +1 more source