Results 11 to 20 of about 60,739 (253)
Characterization of a ranavirus inhibitor of the antiviral protein kinase PKR [PDF]
BMC Microbiology, 2011 Background Ranaviruses (family Iridoviridae) are important pathogens of lower vertebrates. However, little is known about how they circumvent the immune response of their hosts.
Chinchar V Gregory +2 more
doaj +4 more sources
Advancement of science, 2023 Senescence is associated with tumor metastasis and chemotherapy resistance, yet the mechanisms remain elusive. Here, it is identified that nasopharyngeal carcinoma (NPC) patients who developed distant metastasis are characterized by senescence phenotypes,
Qian Li +12 more
semanticscholar +1 more source
RNA circles with minimized immunogenicity as potent PKR inhibitors.
Molecules and Cells, 2021 Exon back-splicing-generated circular RNAs, as a group, can suppress double-stranded RNA (dsRNA)-activated protein kinase R (PKR) in cells. We have sought to synthesize immunogenicity-free, short dsRNA-containing RNA circles as PKR inhibitors.
Chu-Xiao Liu +5 more
semanticscholar +1 more source
Journal of Hematology & Oncology, 2022 Background Circular RNAs (circRNAs) represent a novel type of regulatory RNA characterized by high evolutionary conservation and stability. CircRNAs are expected to be potential diagnostic biomarkers and therapeutic targets for a variety of malignancies.
Xiaolong Wang +12 more
semanticscholar +1 more source
dsRNA-induced condensation of antiviral proteins modulates PKR activity
Proceedings of the National Academy of Sciences of the United States of America, 2022 Significance The presence of dsRNA in the cytosol is a marker of infection and elicits an immune response. One aspect of this immune response is the activation of the eIF2α kinase PKR, which results in translational reprogramming and stress granule ...
Giulia A. Corbet +4 more
semanticscholar +1 more source
The role of PKR/eIF2α signaling pathway in prognosis of non-small cell lung cancer. [PDF]
PLoS ONE, 2011 In this study, we investigated whether PKR protein expression is correlated with mRNA levels and also evaluated molecular biomarkers that are associated with PKR, such as phosphorylated PKR (p-PKR) and phosphorylated eIF2α (p-eIF2α).We determined the ...
Yong He +11 more
doaj +1 more source
Viral evasion of PKR restriction by reprogramming cellular stress granules
Proceedings of the National Academy of Sciences of the United States of America, 2022 Significance Evolutionarily conserved protein kinase R (PKR) is a powerful mediator of antiviral responses. Enigmatically, PKR activity is disabled by porcine reproductive and respiratory syndrome virus (PRRSV) during infection, while the virus still ...
Peng Gao +10 more
semanticscholar +1 more source
Cells, 2020 Background: Calcific aortic valve disease (CAVD) is a chronic inflammatory disease. Soluble extracellular matrix (ECM) proteins can act as damage-associated molecular patterns and may induce valvular inflammation.
Erlinda The +6 more
doaj +1 more source
Target Misfolded Protein Clearance Pathway for Cancer Therapy
Proceedings, 2020 The role of RNA-dependent protein kinase R (PKR) and its association with misfolded protein expression in cancer cells are unclear. Herein we report that PKR regulates misfolded protein clearance by preventing it release through exosomes and promoting ...
Apar Pataer
doaj +1 more source
Increased expression of the dsRNA-activated protein kinase PKR in breast cancer promotes sensitivity to doxorubicin. [PDF]
PLoS ONE, 2012 It has been reported that the expression and activity of the interferon-inducible, dsRNA-dependent protein kinase, PKR, is increased in mammary carcinoma cell lines and primary tumor samples.
Richard L Bennett +5 more
doaj +1 more source