Results 21 to 30 of about 60,739 (253)
A tale of two proteins: PACT and PKR and their roles in inflammation
The FEBS Journal, 2021 Inflammation is a pathological hallmark associated with bacterial and viral infections, autoimmune diseases, genetic disorders, obesity and diabetes, as well as environmental stresses including physical and chemical trauma.
E. Chukwurah +4 more
semanticscholar +1 more source
Signaling by the integrated stress response kinase PKR is fine-tuned by dynamic clustering
bioRxiv, 2021 The double-stranded RNA sensor kinase PKR is one of four integrated stress response (ISR) sensor kinases that phosphorylate the alpha subunit of the eukaryotic initiation factor 2 (eIF2α) in response to stress.
F. Zappa +3 more
semanticscholar +1 more source
Contribution of dsRBD2 to PKR Activation [PDF]
ACS Omega, 2021 Protein kinase R (PKR) is a key pattern recognition receptor of the innate immune pathway. PKR is activated by double-stranded RNA (dsRNA) that is often produced during viral genome replication and transcription. PKR contains two tandem double-stranded RNA binding domains at the N-terminus, dsRBD1 and dsRBD2, and a C-terminal kinase domain.
Stephen Hesler +3 more
openaire +3 more sources
Journal of Pharmacology and Experimental Therapeutics, 2021 In Alzheimer disease (AD), the double-strand RNA-dependent kinase protein kinase R (PKR )/EIF2AK2 is activated in brain with increased phosphorylation of its substrate eukaryotic initiation factor 2α (eIF2α).
M. López-Grancha +11 more
semanticscholar +1 more source
PKR-Dependent Inflammatory Signals [PDF]
Science Signaling, 2012 The RNA-dependent protein kinase activates the inflammasome to promote inflammation.
Rui, Kang, Daolin, Tang
openaire +2 more sources
PKR stirs up inflammasomes [PDF]
Cell Research, 2012 Inflammasomes are multiprotein complexes that detect and respond to foreign and endogenous danger signals by activating caspase-1; active caspase-1, in turn, matures the pro-inflammatory IL-1β family cytokines by cleaving their pro-forms into the biologically active cytokines.
Stunden, H James, Latz, Eicke
openaire +3 more sources
Journal of Orthopaedic Surgery, 2022 Background Despite the established advantages of partial knee replacements (PKR), their usage remains limited. We investigated the effect of hospital knee arthroplasty (KA) volume and the availability of a frequently used PKR by the total KA supplier on ...
Iris Koenraadt-van Oost +5 more
doaj +1 more source
Activation of PKR by RNA misfolding: HDV ribozyme dimers activate PKR [PDF]
RNA, 2012 Protein Kinase R (PKR), the double-stranded RNA (dsRNA)-activated protein kinase, plays important roles in innate immunity. Previous studies have shown that PKR is activated by long stretches of dsRNA, RNA pseudoknots, and certain single-stranded RNAs; however, regulation of PKR by RNAs with globular tertiary structure has not been reported.
Laurie A, Heinicke, Philip C, Bevilacqua
openaire +2 more sources
Structure and Degradation of Circular RNAs Regulate PKR Activation in Innate Immunity.
Cell, 2019 Circular RNAs (circRNAs) produced from back-splicing of exons of pre-mRNAs are widely expressed, but current understanding of their functions is limited.
Chu-Xiao Liu +14 more
semanticscholar +1 more source
Metformin inhibits RAN translation through PKR pathway and mitigates disease in C9orf72 ALS/FTD mice
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Repeat-associated non-AUG (RAN) proteins accumulate in patient brains and contribute to a growing number of neurodegenerative diseases. There is an urgent need to understand why expression of these proteins does not require canonical or near-
T. Zu +12 more
semanticscholar +1 more source