Results 31 to 40 of about 60,739 (253)

Role of protein kinase R in the killing of Leishmania major by macrophages in response to neutrophil elastase and TLR4 via TNF and IFN [PDF]

, 2014
In cutaneous leishmaniasis, Leishmania amazonensis activates macrophage double-stranded, RNA-activated protein kinase R (PKR) to promote parasite growth. In our study, Leishmania major grew normally in RAW cells, RAW-expressing dominant-negative PKR (PKR-
Abu-Dayyeh I., Aislan de Carvalho Vivarini, Ana Paula C. A. Lima, Da Silva R., Danelli M. G., Jeremy C. Mottram, Marilia S. Faria, Nylen S., Tereza C. Calegari‐Silva, Ulisses Gazos Lopes, Vivarini Ade C.   +10 more
core   +1 more source

Ebola virus VP35 induces high-level production of recombinant TPL-2–ABIN-2–NF-κB1 p105 complex in co-transfected HEK-293 cells [PDF]

, 2013
Activation of PKR (double-stranded-RNA-dependent protein kinase) by DNA plasmids decreases translation, and limits the amount of recombinant protein produced by transiently transfected HEK (human embryonic kidney)-293 cells.
Apostolaki, Baldi, Beinke, Beinke, Beinke, Beinke, Beinke, Belich, Bouwmeester, Ciechanover, Cohen, Coope, Costa, Dauber, Dumitru, Durocher, Elke MÜHLBERGER, Feng, Gantke, Geisse, George, Gray, Jia, Jia, Julia Janzen, Kabouridis, Kaufman, Lang, Liu, Nicholas A. Morrice, Papoutsopoulou, Pomerantz, Robinson, Roget, Sabrina Boussouf, Salmeron, Salmeron, Savinova, Schlaeger, Schumann, Steven Howell, Steven C. Ley, Thorsten Gantke, Waterfield, Waterfield, Wu, Yang, Zhao   +47 more
core   +1 more source

The PKR activator, PACT, becomes a PKR inhibitor during HIV-1 replication [PDF]

Retrovirology, 2013
Abstract Background HIV-1 translation is modulated by the activation of the interferon (IFN)-inducible Protein Kinase RNA-activated (PKR). PKR phosphorylates its downstream targets, including the alpha subunit of the eukaryotic translation Initiation Factor 2 (eIF2α), which decreases viral replication.
Clerzius, G, Shaw, E, Daher, A, Burugu, S, Gelinas, J, Ear, T, Sinck, L, Routy, J, Mouland, A, Patel, R, Gatignol, A   +10 more
openaire   +2 more sources

Enhanced Replication of Mouse Adenovirus Type 1 following Virus-Induced Degradation of Protein Kinase R (PKR)

mBio, 2019
Protein kinase R (PKR) plays a major role in activating host immunity during infection by sensing double-stranded RNA (dsRNA) produced by viruses. Once activated by dsRNA, PKR phosphorylates the translation factor eukaryotic initiation factor 2α (eIF2α),
Danielle E. Goodman, Carla D. Pretto, Tomas A. Krepostman, Kelly E. Carnahan, Katherine R. Spindler   +4 more
doaj   +1 more source

Socio-Ecological Factors Influencing Maternal and Child Health Outcomes During Floods in South Punjab Pakistan 2025: A Mixed-Methods Approach. [PDF]

Health Expect
ABSTRACT Background South Punjab, Pakistan, is located approximately nearby the Indus and Chanab rivers. Heavy monsoon and climate change make the situation worse every year, and these areas suffer from severe flooding. Millions of people face challenges in accessing the medical facility, hindered resource availability, damaged infrastructure and a ...
Hassan MM, Alnssyan BS, Ullah MA, Ameeq M, Kargbo A.   +4 more
europepmc   +2 more sources

Penetration Resistance: PKR's Other Talent [PDF]

Immunity, 2012
In this issue of Immunity, Irving et al. (2012) show that protein kinase R (PKR) regulates the cytoskeleton via an interaction with gelsolin. This alternative role for PKR prevents penetration of virions into the cell.
Lacy-Hulbert, Adam, Stuart, Lynda M.
openaire   +2 more sources

Protein Kinase R Degradation Is Essential for Rift Valley Fever Virus Infection and Is Regulated by SKP1-CUL1-F-box (SCF)FBXW11-NSs E3 Ligase. [PDF]

PLoS Pathogens, 2016
Activated protein kinase R (PKR) plays a vital role in antiviral defense primarily by inhibiting protein synthesis and augmenting interferon responses. Many viral proteins have adopted unique strategies to counteract the deleterious effects of PKR.
Rajini Mudhasani, Julie P Tran, Cary Retterer, Krishna P Kota, Chris A Whitehouse, Sina Bavari   +5 more
doaj   +1 more source

Metformin Ameliorates Diabetic Cardiomyopathy by Activating the PK2/PKR Pathway

Frontiers in Physiology, 2020
Diabetic cardiomyopathy (DCM) is a complication of diabetes that can cause damage to myocardial structure and function. Metformin (Met) is a widely used type 2 diabetes treatment drug that exerts cardioprotective effects through multiple pathways ...
Zhen Yang, Min Wang, Yuchen Zhang, Fei Cai, Botao Jiang, W. Zha, Wei Yu   +6 more
semanticscholar   +1 more source

Public-Key Encryption with Delegated Search [PDF]

, 2011
In public-key setting, Alice encrypts email with public key of Bob, so that only Bob will be able to learn contents of email. Consider scenario when computer of Alice is infected and unbeknown to Alice it also embeds malware into message.
Hartel, Pieter, Ibraimi, Luan, Jonker, Willem, Nikova, Svetla   +3 more
core   +3 more sources

PKR and GCN2 stress kinases promote an ER stress-independent eIF2α phosphorylation responsible for calreticulin exposure in melanoma cells

OncoImmunology, 2018
The immunogenic cell death (ICD) process represents a novel therapeutic approach to treat tumours, in which cytotoxic compounds promote both cancer cell death and the emission of damage-associated molecular patterns (DAMPs) from dying cells, to activate ...
Paola Giglio, Mara Gagliardi, Nicola Tumino, Fernanda Antunes, Soraya Smaili, Diego Cotella, Claudio Santoro, Roberta Bernardini, Maurizio Mattei, Mauro Piacentini, Marco Corazzari   +10 more
doaj   +1 more source