Results 71 to 80 of about 60,739 (253)

Protein kinase regulated by dsRNA downregulates the interferon production in dengue virus- and dsRNA-stimulated human lung epithelial cells. [PDF]

PLoS ONE, 2013
Dengue virus (DENV) is found in the tropical and subtropical regions and affects millions of people annually. Currently, no specific vaccine or antiviral treatment against dengue virus is available. Innate immunity has been shown to be important for host
Yuye Li, Jiong Xie, Siyu Wu, Jun Xia, Peifen Zhang, Chao Liu, Ping Zhang, Xi Huang   +7 more
doaj   +1 more source

An integrated stress response via PKR suppresses HER2+ cancers and improves trastuzumab therapy

Nature Communications, 2019
Trastuzumab is integral to HER2+ cancer treatment, but its therapeutic index is narrowed by the development of resistance. Phosphorylation of the translation initiation factor eIF2α (eIF2α-P) is the nodal point of the integrated stress response, which ...
C. Darini, N. Ghaddar, C. Chabot, Gloria Assaker, S. Sabri, Shuo Wang, J. Krishnamoorthy, M. Buchanan, A. Aguilar-Mahecha, B. Abdulkarim, J. Deschênes, Jose Torres, Josie Ursini-Siegel, M. Basik, A. Koromilas   +14 more
semanticscholar   +1 more source

Interaction of PKR with Single Stranded RNA [PDF]

Biophysical Journal, 2017
AbstractAlthough the antiviral kinase PKR was originally characterized as a double-stranded RNA activated enzyme it can be stimulated by RNAs containing limited secondary structure. Single-stranded regions in such RNAs contribute to binding and activation but the mechanism is not understood.
Christopher B. Mayo, James L. Cole
openaire   +3 more sources

Rapid evolution of protein kinase PKR alters sensitivity to viral inhibitors. [PDF]

, 2009
Protein kinase PKR (also known as EIF2AK2) is activated during viral infection and phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF2), leading to inhibition of translation and viral replication. We report fast evolution
Dever, Thomas E, Dittmar, Katharina, Gibbs, James S, Rothenburg, Stefan, Seo, Eun Joo   +4 more
core  

Hamiltonian symmetries in auxiliary-field quantum Monte Carlo calculations for electronic structure [PDF]

, 2019
We describe how to incorporate symmetries of the Hamiltonian into auxiliary-field quantum Monte Carlo calculations (AFQMC). Focusing on the case of Abelian symmetries, we show that the computational cost of most steps of an AFQMC calculation is reduced ...
Chan, Garnet Kin-Lic, Motta, Mario, Zhang, Shiwei   +2 more
core   +2 more sources

Alkyltriphenylphosphonium Binding to Cardiolipin Triggers Oncosis in Cancer Cells

Advanced Science, EarlyView.
Alkyltriphenylphosphonium, exemplified by TPP+‐C14, preferentially accumulates in mitochondria and selectively binds to cardiolipin, a key phospholipid of the inner mitochondrial membrane, causing loss of mitochondrial membrane potential, severe cellular ATP depletion, and calcium imbalance.
Jin Li, Hang Zheng, Yuxing Lin, Ziwei Zhao, Yijia Mai, Zhangrong Lou, Qiang Liu, Zhao Ma, Chengjun Wu   +8 more
wiley   +1 more source

The search for a PKR code—differential regulation of protein kinase R activity by diverse RNA and protein regulators

RNA: A publication of the RNA Society, 2019
The interferon-inducible protein kinase R (PKR) is a key component of host innate immunity that restricts viral replication and propagation. As one of the four eIF2α kinases that sense diverse stresses and direct the integrated stress response (ISR ...
C. Bou-Nader, Jackson M Gordon, Frances E. Henderson, Jinwei Zhang   +3 more
semanticscholar   +1 more source

The caspase-generated fragments of PKR cooperate to activate full-length PKR and inhibit translation [PDF]

Cell Death & Differentiation, 2007
We have studied the involvement of receptor interacting protein kinase-1 (RIP1) and dsRNA-activated protein kinase (PKR) in external dsRNA-induced apoptotic and necrotic cell death in Jurkat T cell lymphoma. Our results suggest that RIP1 plays an imported role in dsRNA-induced apoptosis and necrosis.
M, Kalai, V, Suin, N, Festjens, A, Meeus, A, Bernis, X-M, Wang, X, Saelens, P, Vandenabeele   +7 more
openaire   +2 more sources

Decoding the Integrated Stress Response of Pancreatic Cancer: Identifying a Serine‐dependent Tumor Subset Under Metabolic Relationships With CAFs.

Advanced Science, EarlyView.
Researchers identified a pancreatic cancer subset with low global protein synthesis but heightened translation of stress‐response genes like ATF4, rendering cells resistant to chemotherapy and apoptosis. These tumors depend on serine and cysteine from surrounding cancer‐associated fibroblasts (CAFs), which shift to produce serine by curbing collagen ...
Sauyeun Shin, Mehdi Liauzun, Jacobo Solorzano, Morgane Le Bras, Christine Jean, Benjamin Fourneaux, Margaux Dore, Lea Fevrier, Ismahane Belhabib, Alexia Brunel, Cindy Neuzillet, Marion Larroque, Carine Joffre, Stephane Rocchi, Nicolas Fraunhoffer, Aurelie Perraud, Muriel Mathonnet, Vera Pancaldi, Laetitia Linares, Juan Iovanna, Nelson Dusetti, Ola Larsson, Remy Nicolle, Stephane Pyronnet, Corinne Bousquet, Yvan Martineau   +25 more
wiley   +1 more source

Compressive PCA for Low-Rank Matrices on Graphs [PDF]

, 2016
We introduce a novel framework for an approxi- mate recovery of data matrices which are low-rank on graphs, from sampled measurements. The rows and columns of such matrices belong to the span of the first few eigenvectors of the graphs constructed ...
Perraudin, Nathanael, Puy, Gilles, Shahid, Nauman, Vandergheynst, Pierre   +3 more
core   +6 more sources