Results 91 to 100 of about 1,501,016 (387)

Colchicine Concentrations and Relationship With Colchicine Efficacy and Adverse Events: Post Hoc Analysis of a Randomized Clinical Trial of Colchicine for Gout Flare Prophylaxis

Arthritis Care &Research, EarlyView.
Objective Our objective was to examine the relationship between colchicine plasma concentrations and clinical and demographic factors and to determine the relationship between colchicine concentrations and colchicine efficacy and colchicine‐specific adverse events.
Lisa K. Stamp, Anne Horne, Borislav Mihov, Jill Drake, Janine Haslett, Peter Chapman, Daniel F. B. Wright, Christopher Frampton, Nicola Dalbeth   +8 more
wiley   +1 more source

Secukinumab, a human anti-interleukin-17A monoclonal antibody, in patients with psoriatic arthritis (FUTURE 2): a randomised, double-blind, placebo-controlled, phase 3 trial [PDF]

, 2015
Background: Interleukin 17A is a proinflammatory cytokine that is implicated in the pathogenesis of psoriatic arthritis. We assessed the efficacy and safety of subcutaneous secukinumab, a human anti-interleukin-17A monoclonal antibody, in patients ...
Conaghan, Philip G., Gottlieb, Alice B., Kavanaugh, Arthur, Kirkham, Bruce, Landewé, Robert, Ligozio, Gregory, McInnes, Iain B., Mease, Philip J., Mpofu, Shephard, Patekar, Manmath, Pricop, Luminita, Rahman, Proton, Richards, Hanno, Ritchlin, Christopher T., van der Heijde, Désirée   +14 more
core   +1 more source

A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis.

New England Journal of Medicine, 2012
BACKGROUND Ruxolitinib, a selective inhibitor of Janus kinase (JAK) 1 and 2, has clinically significant activity in myelofibrosis. METHODS In this double-blind trial, we randomly assigned patients with intermediate-2 or high-risk myelofibrosis to twice-
S. Verstovsek, R. Mesa, J. Gotlib, R. Levy, Vikas Gupta, J. Dipersio, J. Catalano, M. Deininger, Carole B. Miller, R. Silver, M. Talpaz, E. Winton, J. Harvey, M. Arcasoy, E. Hexner, R. Lyons, R. Paquette, A. Raza, K. Vaddi, S. Erickson‐Viitanen, I. Koumenis, William Sun, V. Sandor, H. Kantarjian   +23 more
semanticscholar   +1 more source

Gastrointestinal Perforation as a Safety Concern Among Patients With Rheumatoid Arthritis Receiving JAK Inhibitor Therapy: A Systematic Review and Network Meta‐Analysis

Arthritis Care &Research, EarlyView.
Objective Gastrointestinal perforation (GIP) is a rare and life‐threatening safety concern associated with JAK inhibitors (JAKi). We aimed to review the evidence regarding the risk of GIP associated with the use of JAKi in patients with rheumatoid arthritis (RA) using a systematic review and network meta‐analysis approach.
Thipsukhon Sathapanasiri, Manuel Meraz, Hamraz Mokri, Sajesh K Veettil, Karn Wijarnpreecha, Naomi Schlesinger, Arthur Kavanaugh, Nathorn Chaiyakunapruk   +7 more
wiley   +1 more source

EL PLACEBO: LUCES Y SOMBRAS Placebo: Lights and shadows

Revista Habanera de Ciencias Médicas, 2008
Se realiza una revisión sobre el placebo definiéndose su concepto, así como del efecto placebo, sus reacciones en el organismo, utilidad en las investigaciones, sus posibles usos en la práctica médica y los peligros de su empleo.
José Díaz Novás
doaj  

Demonstration of safety of intravenous immunoglobulin in geriatric patients in a long-term, placebo-controlled study of Alzheimer's disease. [PDF]

, 2016
INTRODUCTION:We present safety results from a study of Gammagard Liquid intravenous immunoglobulin (IGIV) in patients with probable Alzheimer's disease. METHODS:This was a placebo-controlled double-blind study.
Aisen, Paul, Brewer, James B, Britt, Jonathan, Doralt, Jennifer, Dyck-Jones, Jacqueline A, Fritsch, Sandor, Gelmont, David, Rissman, Robert A, Thomas, Ronald G   +8 more
core   +2 more sources

Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations

Advanced Functional Materials, EarlyView.
Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan, Simona Summonte, Fabrizio Ricci, Matthias Sandmeier, Andreas Bernkop‐Schnürch   +4 more
wiley   +1 more source

A prospective case–control trial to evaluate and compare the efficacy and safety of atosiban versus placebo in In vitro Fertilization-embryo transfer program

Journal of Human Reproductive Sciences, 2018
Background: Recent developments in assisted reproductive technology focus on potential advances to improve its success rate. Atosiban, a combined oxytocin/vasopressin V1a receptor antagonist, is a novel class of drug involved in basic priming of the ...
Vineet Mishra, Himani Agarwal, Sugandha Goel, Priyankur Roy, Sumesh Choudhary, Sunita Lamba   +5 more
doaj   +1 more source

DHA-rich oil modulates the cerebral haemodynamic response to cognitive tasks in healthy young adults: a near IR spectroscopy pilot study [PDF]

, 2011
The impact of dietary n-3 PUFA on behavioural outcomes has been widely researched; however, very little attention has been given to their impact on brain functioning in physiological terms.
Jackson, Philippa, Kennedy, David, Reay, Jonathon, Scholey, Andrew   +3 more
core   +1 more source

Mind matters: Placebo enhances reward learning in Parkinson’s disease

Nature Neuroscience, 2014
Expectations have a powerful influence on how we experience the world. Neurobiological and computational models of learning suggest that dopamine is crucial for shaping expectations of reward and that expectations alone may influence dopamine levels ...
Bosiljka Tasic, V. Menon, T. Nguyen, Tae Kyung Kim, T. Jarsky, Zizhen Yao, Boaz P. Levi, Lucas T Gray, S. Sorensen, Tim Dolbeare, Darren Bertagnolli, Jeff Goldy, N. Shapovalova, Sheana E. Parry, Changkyu Lee, Kimberly A. Smith, Amy Bernard, L. Madisen, S. Sunkin, M. Hawrylycz, C. Koch, Hongkui Zeng   +21 more
semanticscholar   +1 more source