Results 81 to 90 of about 1,543,966 (410)

Effect of Cyclooxygenase(COX)-1 and COX-2 inhibition on furosemide-induced renal responses and isoform immunolocalization in the healthy cat kidney [PDF]

, 2015
BACKGROUND: The role of cyclooxygenase(COX)-1 and COX-2 in the saluretic and renin-angiotensin responses to loop diuretics in the cat is unknown. We propose in vivo characterisation of isoform roles in a furosemide model by administering non-steroidal ...
A Hayes, B Mann, B Rose, B Rose, B Rose, CM Hao, DA Heller, DO Stichtenoth, F Catella-Lawson, F Nantel, G Giovanni, H Syme, H. Syme, J Hippisley-Cox, J Peti-Peterdi, J. Elliott, J. N. King, JA Jakobsen, K Schumacher, K. Smith, KA Kirchner, KL Therland, KN Khan, KN Khan, L Pelligand, L Pelligand, L. Pelligand, M Komhoff, M Meskell, M Sabbatini, N. Suemanotham, P. Lees, PA Friedman, RC Harris, RC Harris, RE Jepson, S Yu, V Campean, V Sreenivasan, VB Schmid, W. Seewald, WA Corsini, XR He   +42 more
core   +2 more sources

Olink Proteomics Analysis Reveals Heterogeneous Responses to FcRn Blockade in Anti‐AChR Antibody‐Positive Myasthenia Gravis: FGF‐19 as a Novel Biomarker

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to systematically observe the clinical manifestations, immune cell subsets, and dynamic changes in serological indicators in patients with myasthenia gravis (MG) before and after efgartigimod (EFG) treatment. Methods We analyzed the baseline data, laboratory parameters, and lymphocyte subset proportions in MG ...
Tiancheng Luo, Deyou Peng, Zhouao Zhang, Mingjin Yang, Xinyan Guo, Tianyu Ma, Xiaoyu Huang, Mingming Xu, Linlin Fu, Yong Zhang   +9 more
wiley   +1 more source

Randomisation in a clinical trial: is it feasible in the Ebola crisis? If it is, then which method is suitable?

Southern African Journal of Infectious Diseases, 2016
Randomisation is an integral component of any sensible clinical trial. Randomisation is the only way we can be sure that the patients have been allocated into the treatment arms with as minimum bias as possible, and that the treatment arms are similar ...
Jesca M. Batidzirai
doaj   +1 more source

Blinded patient preference for morphine compared to placebo in the setting of chronic refractory breathlessness – an exploratory study [PDF]

, 2015
Context Patients’ preference for morphine therapy has received little attention in the setting of chronic refractory breathlessness. However, this is one important factor in considering longer term therapy.
Abernethy, Amy P., Currow, David C., Ferreira, Diana H., Johnson, Miriam J., Oxberry, Stephen G., Quinn, Stephen, Silva, José P.   +6 more
core   +1 more source

Implications of Placebo and Nocebo Effects for Clinical Practice: Expert Consensus

Psychotherapy and Psychosomatics, 2018
Background: Placebo and nocebo effects occur in clinical or laboratory medical contexts after administration of an inert treatment or as part of active treatments and are due to psychobiological mechanisms such as expectancies of the patient. Placebo and
A. Evers, L. Colloca, Charlotte R Blease, M. Annoni, L. Atlas, F. Benedetti, U. Bingel, C. Büchel, Cláudia Carvalho, B. Colagiuri, A. Crum, P. Enck, J. Gaab, Andrew L. Geers, J. Howick, Karin B. Jensen, I. Kirsch, K. Meissner, V. Napadow, Kaya J. Peerdeman, A. Raz, W. Rief, L. Vase, T. Wager, B. Wampold, K. Weimer, K. Wiech, T. Kaptchuk, R. Klinger, J. Kelley   +29 more
semanticscholar   +1 more source

Will Memantine Exacerbate Seizures in People With Epilepsy? A Prospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate whether add‐on memantine would exacerbate seizures in people with epilepsy. Methods This was a prospective cohort study. People with epilepsy diagnosed with cognitive impairment were consecutively invited. Those who agreed were followed up for at least 24 weeks.
Peiyu Wang, Lu Lu, Hui Gao, Qi Zhang, Jing Xiao, Josemir W. Sander, Weixi Xiong, Dong Zhou   +7 more
wiley   +1 more source

Chronic cough and esomeprazole: A double-blind placebo-controlled parallel study [PDF]

, 2011
Background and objective: Gastro-oesophageal reflux has been implicated in the pathogenesis of chronic cough. Guidelines on management suggest a therapeutic trial of anti-reflux medication.
Beecher, Belafsky, Birring, Blondeau, Chang, Corley, Decalmer, DeVault, Dial, Eccles, Eherer, Everett, Faruqi, FitzGerald, Gilard, Gulmez, Hemmink, Herzig, Ing, Irwin, Irwin, Irwin, Irwin, Juurlink, Laheij, Lenglinger, Mastronarde, Morice, Morice, Morice, Morice, Noordzij, Pratter, Rostami-Hodjegan, Shaheen, Vaezi, Vertigan, Wager, Waring, Wo, Yang, Yearsley   +41 more
core   +1 more source

Daratumumab Treatment for Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP): A Case Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an immune‐mediated neuropathy featuring progressive weakness, sensory deficits, and areflexia. While corticosteroids, intravenous immunoglobulin, and plasmapheresis are effective first‐line immunotherapies, a subset of patients remains treatment‐refractory.
Xueyu Zhang, Jianli Zhao, Xue Zhao, Xiaowei Hu, Zichun Xiao, Jie Wu, Xiaowen Li, Jing Xu, Yu‐Jing Li   +8 more
wiley   +1 more source

Developing evidence-based guidelines for describing potential benefits and harms within patient information leaflets/sheets (PILs) that inform and do not cause harm (PrinciPILs)

Health Technology Assessment
Background Variation in the way information about potential trial intervention benefits and harms is conveyed within patient information leaflets can cause avoidable information-induced (‘nocebo’) harm, research waste, and may be unethical. Objectives To
Jeremy Howick, Martina Svobodova, Shaun Treweek, Katie Gillies, Adrian Edwards, Peter Bower, Jennifer Bostock, Nina Jacob, Kerenza Hood   +8 more
doaj   +1 more source

Inhibition of alpha oscillations through serotonin-2A receptor activation underlies the visual effects of ayahuasca in humans [PDF]

, 2016
Ayahuasca is an Amazonian psychotropic plant tea typically obtained from two plants, Banisteriopsis caapi and Psychotria viridis. It contains the psychedelic 5-HT2A and sigma-1 agonist N,N-dimethyltryptamine (DMT) plus ß-carboline alkaloids with ...
Alonso, Joan Francesc, Antonijoan Arbós, Rosa Ma (Rosa María), Barker, Steven, Feilding, Amanda, Friedlander, Pablo, Maqueda, Ana Elda, Mañanas, Miquel Àngel, Rabella, Mireia, Riba, Jordi, Rodríguez-Pujadas, Aina, Romero, Sergio, Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia, Valle, Marta   +12 more
core   +3 more sources