Chronic cough and esomeprazole: A double-blind placebo-controlled parallel study [PDF]
Background and objective: Gastro-oesophageal reflux has been implicated in the pathogenesis of chronic cough. Guidelines on management suggest a therapeutic trial of anti-reflux medication.
Beecher+41 more
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Not a Placebo, but Is It Effective? [PDF]
Randomized, placebo-controlled studies are a rare commodity in interventional pain medicine. Pain Medicine , is therefore, pleased to publish such a study, in which Kappural et al. report their results of transdiscal biacuplasty for the treatment of chronic low back pain ⇓. Publication recognizes that a study was methodologically sound.
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The placebo effect is a fascinating phenomenon in clinical practice. Studies have shown that there is a significant placebo effect in a wide range of medical conditions including psychiatric disorders. This article looks at the background of the placebo effect, defines the common terms used, describes the various hypotheses that have been put forward ...
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Effects of creatine monohydrate supplementation on simulated soccer performance [PDF]
Purpose: To determine the effects of acute short-term creatine (Cr) supplementation on physical performance during a 90-min soccer-specific performance test. Methods: A double-blind, placebo-controlled experimental design was adopted during which 16 male
Abt, Grant+2 more
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Citalopram plus low-dose pipamperone versus citalopram plus placebo in patients with major depressive disorder: an 8-week, double-blind, randomized study on magnitude and timing of clinical response [PDF]
Background: Selective serotonin reuptake inhibitors take several weeks to achieve their full antidepressant effects. Post-synaptic 5-HT<sub>2A</sub> receptor activation is thought to be involved in this delayed therapeutic effect ...
A. F. Schatzberg+14 more
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The glycaemic effects of single doses of Panax ginseng in young healthy volunteers [PDF]
The results of two acute placebo-controlled, double-blind cross-over studies assessing the effect of Panax ginseng (G115) on blood glucose levels are reported.
Kennedy, David+2 more
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Effect of tranexamic acid in traumatic brain injury: a nested randomised, placebo controlled trial (CRASH-2 Intracranial Bleeding Study). [PDF]
OBJECTIVE: To assess the effect of tranexamic acid (which reduces bleeding in surgical patients and reduces mortality due to bleeding in trauma patients) on intracranial haemorrhage in patients with traumatic brain injury.
CRASH-2 Collaborators, Intracranial Bleeding Study
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Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness [PDF]
BACKGROUND: There are conflicting data on the effects of antipsychotic medications on delirium in patients in the intensive care unit (ICU). METHODS: In a randomized, double-blind, placebo-controlled trial, we assigned patients with acute ...
Bernard, G.R.+31 more
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In this issue of SLEEP, Kushida and colleagues1 report neurocognitive performance results from a large, multi-site, double blind, controlled, randomized clinical trial on the effects of long-term continuous positive airway pressure (CPAP) therapy.1–3 In this trial, 1,098 patients with obstructive sleep apnea were randomized to active CPAP or sham ...
Schwartz, Skai W.+2 more
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When a placebo is not a ‘placebo’: a placebo effect on postprandial glycaemia [PDF]
What is already known about this subject • Although placebo effects have been shown on subjective continuous variables such as pain, placebo effects on objective continuous variables remain uncertain.• The present, pilot, follow‐up investigation represents the first to assess a placebo effect on the objective continuous measurement of acute ...
Vladimir Vuksan+3 more
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