Results 31 to 40 of about 9,905,323 (311)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

What Is the Role of the Placebo Effect for Pain Relief in Neurorehabilitation? Clinical Implications From the Italian Consensus Conference on Pain in Neurorehabilitation

Frontiers in Neurology, 2018
BackgroundIt is increasingly acknowledged that the outcomes of medical treatments are influenced by the context of the clinical encounter through the mechanisms of the placebo effect. The phenomenon of placebo analgesia might be exploited to maximize the
Gianluca Castelnuovo, Gianluca Castelnuovo, Emanuele Maria Giusti, Emanuele Maria Giusti, Gian Mauro Manzoni, Gian Mauro Manzoni, Donatella Saviola, Samantha Gabrielli, Marco Lacerenza, Giada Pietrabissa, Giada Pietrabissa, Roberto Cattivelli, Roberto Cattivelli, Chiara Anna Maria Spatola, Chiara Anna Maria Spatola, Alessandro Rossi, Giorgia Varallo, Margherita Novelli, Valentina Villa, Francesca Luzzati, Andrea Cottini, Carlo Lai, Eleonora Volpato, Eleonora Volpato, Cesare Cavalera, Francesco Pagnini, Francesco Pagnini, Valentina Tesio, Lorys Castelli, Mario Tavola, Riccardo Torta, Marco Arreghini, Loredana Zanini, Amelia Brunani, Ionathan Seitanidis, Giuseppe Ventura, Paolo Capodaglio, Guido Edoardo D’Aniello, Guido Edoardo D’Aniello, Federica Scarpina, Andrea Brioschi, Matteo Bigoni, Lorenzo Priano, Lorenzo Priano, Alessandro Mauro, Alessandro Mauro, Giuseppe Riva, Giuseppe Riva, Daniele Di Lernia, Claudia Repetto, Camillo Regalia, Enrico Molinari, Enrico Molinari, Paolo Notaro, Stefano Paolucci, Giorgio Sandrini, Giorgio Sandrini, Susan Simpson, Susan Simpson, Brenda Kay Wiederhold, Santino Gaudio, Jeffrey B. Jackson, Stefano Tamburin, Fabrizio Benedetti   +63 more
doaj   +1 more source

Neurobiology of Placebo Effect [PDF]

Psikiyatride Güncel Yaklaşımlar, 2013
Placebo is defined as a substance or method that has no specific effect on the condition being treated. Placebo leads to the state of contentment and shows its effects just like a drug by the pathways in the body. Various changes formed by plasebo on the
Suleyman Akarsu, Murat Erdem, Murat Gulsun   +2 more
doaj   +1 more source

Developing a placebo-controlled trial in surgery: issues of design, acceptability and feasibility [PDF]

, 2011
<p>Background: Surgical placebos are controversial. This in-depth study explored the design, acceptability, and feasibility issues relevant to designing a surgical placebo-controlled trial for the evaluation of the clinical and cost effectiveness ...
Campbell, MK, McDonald, AM, Skea, Z.C, Sutherland, AG, ZC Skea, Norrie, J.D, Campbell, M.K., Cuthbertson BH, Bridgman, S., McDonald, A.M, BH Cuthbertson, AM McDonald, McDonald AM, RV Carlson, McDonald, A.M., Skea, Z.C., S Bridgman, Carlson, R V, Entwistle, V.A, Sutherland, A.G, Cuthbertson, B H, JD Norrie, Norrie, J. D., Campbell, M K, Cuthbertson, B. H., Skea, Z. C., Skea, ZC, Carlson, RV, Sutherland AG, null null, MK Campbell, Carlson, R.V., Entwistle, Vikki, McDonald, A M, Norrie, JD, Skea ZC, VA Entwistle, Carlson, R.V, Skea, Z C, AG Sutherland, Entwistle, V A, Carlson RV, Entwistle, V.A., Norrie, J D, Sutherland, A.G., Bridgman, S, Norrie, J.D., Entwistle, V. A., Sutherland, A G, Campbell, M.K, Entwistle VA, McDonald, A. M., KORAL study group, Cuthbertson, B.H., Sutherland, A. G., Cuthbertson, B.H, Campbell MK, Campbell, M. K., Entwistle, VA, Cuthbertson, BH, Bridgman S, Carlson, R. V., Norrie JD   +62 more
core   +2 more sources

Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants

Annals of Clinical and Translational Neurology, EarlyView.
Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants. ABSTRACT Objective Return of disease activity is expected when patients discontinue disease‐modifying therapy (DMT) for multiple sclerosis (MS). Some MS DMTs are associated with higher‐than‐expected disease activity (rebound) after discontinuation.
Ralf Gold, Krzysztof W. Selmaj, Regina Berkovich, Jeffrey A. Cohen, Giancarlo Comi, Eva K. Havrdová, James K. Sheffield, Hetal Desai, Chun‐Yen Cheng, Jon V. Riolo, Andrew Thorpe, Erik DeBoer, Bruce A. C. Cree   +12 more
wiley   +1 more source

The transferable placebo effect from pain to emotion: Changes in behavior and EEG activity [PDF]

, 2009
Past studies indicate that the placebo expectation established by analgesic treatment significantly relieves pain perception, while ataractic treatment significantly alleviates unpleasant arousal evoked by negative picture processing.
J. Luo, Zhang, Wencai, Luo, Jing
core   +1 more source

Alternative (non-hormonal) methods of menopausal disorder treatment. Assistance to the doctor-internist

Лечащий Врач, 2021
Climacteric syndrome (CS) is a pathological condition that occurs in a significant part of women in the menopause. Menopausal hormone therapy (MHT) is recognized as the most effective treatment for menopausal disorders. However, in real clinical practice,
I. V. Madyanov, T. S. Madyanova
doaj   +1 more source

Placebo Effects in Oncology [PDF]

JNCI Journal of the National Cancer Institute, 2003
Previous studies have suggested that placebo treatment can have positive effects on a variety of disorders and disease-related symptoms. However, the methodology used to collect and interpret the data may not have been ideal, because the studies were not double-blinded or the endpoints were not properly validated.
Gisèle, Chvetzoff, Ian F, Tannock
openaire   +2 more sources

Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket, J. Lycke, J. Salzer, F. Piehl, K. Fink, N. Lange, J. Mellergård, C. Malmeström, P. Sundström, I. Erngren, A. al‐Grety, E. Freyhult, K. Kultima, J. Burman, A. Svenningsson   +14 more
wiley   +1 more source