Causal diagrams, the placebo effect, and the expectation effect
Eyal Shahar,1 Doron J Shahar2 1Division of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, 2Department of Mathematics, College of Science, University of Arizona, Tucson, AZ, USA Abstract: Using causal diagrams, a formal ...
Shahar E, Shahar DJ
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Placebo effect of an inert gel on experimentally induced leg muscle pain. [PDF]
Purpose: This study examined the therapeutic effects of an inert placebo gel on experimentally induced muscle pain in a sports therapy setting. It aimed to investigate the degree to which conditioned analgesia, coupled with an expectation of intervention,
Coleman, Damian A +4 more
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Meta-analysis of neural systems underlying placebo analgesia from individual participant fMRI data [PDF]
The brain systems underlying placebo analgesia are insufficiently understood. Here we performed a systematic, participant-level meta-analysis of experimental functional neuroimaging studies of evoked pain under stimulus-intensity-matched placebo and ...
Leknes, S. +29 more
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Improved 1000-m Running Performance and Pacing Strategy With Caffeine and Placebo: A Balanced Placebo Design Study. [PDF]
Purpose: To investigate the placebo effect of caffeine on pacing strategy and performance over 1000-m running time trials using a balanced placebo design.
Roelands, Bart +14 more
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When a placebo is not a ‘placebo’: a placebo effect on postprandial glycaemia [PDF]
What is already known about this subject • Although placebo effects have been shown on subjective continuous variables such as pain, placebo effects on objective continuous variables remain uncertain.• The present, pilot, follow‐up investigation represents the first to assess a placebo effect on the objective continuous measurement of acute ...
John L, Sievenpiper +3 more
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Placebo effect in chronic inflammatory demyelinating polyneuropathy: The PATH study and a systematic review [PDF]
The Polyneuropathy And Treatment with Hizentra (PATH) study required subjects with chronic inflammatory demyelinating polyneuropathy (CIDP) to show dependency on immunoglobulin G (IgG) and then be restabilized on IgG before being randomized to placebo or
Cornblath, DR +13 more
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The brain activity of pain relief during hypnosis and placebo treatment
Placebo treatment and hypnosis are both examples of top-down regulation and are used to treat pain. However, it is unclear whether hypnosis produces anything more than a placebo effect when measuring brain activity changes.
Svetlana Kirjanen
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The health economic potential of harnessing placebos in treatment of ADHD
Introduction Placebo research investigated the underlying mechanisms of placebo effects, but they are rarely used to optimize treatments. Ethical and legal concerns have been raised, but research demonstrated that placebo mechanisms can be used without
J. Hamberger +3 more
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Not a Placebo, but Is It Effective? [PDF]
Randomized, placebo-controlled studies are a rare commodity in interventional pain medicine. Pain Medicine , is therefore, pleased to publish such a study, in which Kappural et al. report their results of transdiscal biacuplasty for the treatment of chronic low back pain ⇓. Publication recognizes that a study was methodologically sound.
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Objective: Predicting who will be a placebo responder is a prerequisite to maximize placebo effects in pain treatment and to minimize them in clinical trials. First evidence exists that genetics could affect placebo effects.
Katja Weimer +7 more
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