Chronic cough and esomeprazole: A double-blind placebo-controlled parallel study [PDF]
, 2011 Background and objective: Gastro-oesophageal reflux has been implicated in the pathogenesis of chronic cough. Guidelines on management suggest a therapeutic trial of anti-reflux medication.
Beecher +41 more
core +1 more source
Generalizing the intention-to-treat effect of an active control against placebo from historical placebo-controlled trials to an active-controlled trial: A case study of the efficacy of daily oral TDF/FTC in the HPTN 084 study [PDF]
arXiv, 2023 In many clinical settings, an active-controlled trial design (e.g., a non-inferiority or superiority design) is often used to compare an experimental medicine to an active control (e.g., an FDA-approved, standard therapy). One prominent example is a recent phase 3 efficacy trial, HIV Prevention Trials Network Study 084 (HPTN 084), comparing long-acting
arxiv
BMC Medical Research Methodology, 2016 Background Conventional randomized placebo-controlled study design assumes the absence of drug*placebo interaction. We hypothesized the presence of such an interaction and that conventionally estimated drug effect might be biased.
Muhammad M. Hammami +5 more
doaj +1 more source
Improving adaptive response to negative stimuli through non-emotional working memory training
Frontiers in Behavioral Neuroscience, 2023 People with high working memory (WM) capacity tend to respond proactively and experience a decrease in undesired emotions, implying the potential influence of WM training on emotional responses.
Quanshan Long +6 more
doaj +1 more source
Citalopram plus low-dose pipamperone versus citalopram plus placebo in patients with major depressive disorder: an 8-week, double-blind, randomized study on magnitude and timing of clinical response [PDF]
, 2011 Background: Selective serotonin reuptake inhibitors take several weeks to achieve their full antidepressant effects. Post-synaptic 5-HT<sub>2A</sub> receptor activation is thought to be involved in this delayed therapeutic effect ...
A. F. Schatzberg +14 more
core +1 more source
The Role of Expectation and Beliefs on the Effects of Non-Invasive Brain Stimulation
Brain Sciences, 2021 Non-invasive brain stimulation (NIBS) techniques are used in clinical and cognitive neuroscience to induce a mild magnetic or electric field in the brain to modulate behavior and cortical activation.
Miriam Braga +5 more
doaj +1 more source
Wakening Past Concepts without Past Data: Class-Incremental Learning from Online Placebos [PDF]
arXiv, 2023 Not forgetting old class knowledge is a key challenge for class-incremental learning (CIL) when the model continuously adapts to new classes. A common technique to address this is knowledge distillation (KD), which penalizes prediction inconsistencies between old and new models.
arxiv
Effect of tranexamic acid in traumatic brain injury: a nested randomised, placebo controlled trial (CRASH-2 Intracranial Bleeding Study). [PDF]
, 2011 OBJECTIVE: To assess the effect of tranexamic acid (which reduces bleeding in surgical patients and reduces mortality due to bleeding in trauma patients) on intracranial haemorrhage in patients with traumatic brain injury.
CRASH-2 Collaborators, Intracranial Bleeding Study
core +1 more source
Frontiers in Neurology, 2018 BackgroundIt is increasingly acknowledged that the outcomes of medical treatments are influenced by the context of the clinical encounter through the mechanisms of the placebo effect. The phenomenon of placebo analgesia might be exploited to maximize the
Gianluca Castelnuovo +63 more
doaj +1 more source
Acta Clinica Croatica, 2023 Suggestive preparation before surgery may have a placebo effect and can reduce perioperative consumption of analgesics. A total of 77 adult patients undergoing elective cholecystectomy and hernioplasty were included in this prospective study.
Anja Petričević +3 more
doaj +1 more source