Rolofylline, an adenosine A1−receptor antagonist, in acute heart failure [PDF]
Background: Worsening renal function, which is associated with adverse outcomes, often develops in patients with acute heart failure. Experimental and clinical studies suggest that counterregulatory responses mediated by adenosine may be involved. We
Bloomfield, Daniel M+15 more
core +1 more source
In this issue of SLEEP, Kushida and colleagues1 report neurocognitive performance results from a large, multi-site, double blind, controlled, randomized clinical trial on the effects of long-term continuous positive airway pressure (CPAP) therapy.1–3 In this trial, 1,098 patients with obstructive sleep apnea were randomized to active CPAP or sham ...
Schwartz, Skai W.+2 more
openaire +4 more sources
Placebo effect in clinical practice
The term placebo poses challenges in definition, language and use in research and clinical settings. Placebo extends beyond inactive substances, and modern exploration has revealed complex neurobiological, psychological, and social factors influencing ...
J. M. Bentin+2 more
semanticscholar +1 more source
The effect of placebo and neurophysiological involvements [PDF]
Placebo and placebo effect are important issues related to the drug therapy for clinical and scientific meanings. The rates of placebo may get as many as 50% for analgesic drugs in headache. The high answer to placebo brings questions on pathophysiology
Galli, Federica+2 more
core +1 more source
Exposing the evidence gap for complementary and alternative medicine to be integrated into science-based medicine. [PDF]
When people who advocate integrating conventional science-based medicine with complementary and alternative medicine (CAM) are confronted with the lack of evidence to support CAM they counter by calling for more research, diverting attention to the ...
Hopayian, K, Power, M.
core +1 more source
When a placebo is not a ‘placebo’: a placebo effect on postprandial glycaemia [PDF]
What is already known about this subject • Although placebo effects have been shown on subjective continuous variables such as pain, placebo effects on objective continuous variables remain uncertain.• The present, pilot, follow‐up investigation represents the first to assess a placebo effect on the objective continuous measurement of acute ...
Vladimir Vuksan+3 more
openaire +3 more sources
Intestinal antimicrobial gene expression: impact of micronutrients in malnourished adults during a randomized trial. [PDF]
BACKGROUND: Because both micronutrients and antimicrobial peptides protect against diarrhea, we looked for an effect on intestinal antimicrobial peptide gene expression during a randomized controlled trial of multiple micronutrient (MM) supplementation ...
Bevins, Charles L+8 more
core +1 more source
Critical appraisal and update on the clinical utility of agomelatine, a melatonergic agonist, for the treatment of major depressive disease in adults [PDF]
This article describes the pharmacology of the novel atypical antidepressant drug agomelatine, critically reviews and evaluates its clinical use for the treatment of major depression, and suggests areas for further research.
Howland, RH
core +1 more source
Thyroxine treatment in patients with symptoms of hypothyroidism but thyroid function tests within the reference range: randomised double blind placebo controlled crossover trial [PDF]
OBJECTIVES: To determine whether thyroxine treatment is effective in patients with symptoms of hypothyroidism but with thyroid function tests within the reference range, and to investigate the effect of thyroxine treatment on psychological and physical ...
Davidson, K.M.+6 more
core +2 more sources
Background It is increasingly acknowledged that the outcomes of medical treatments are influenced by the context of the clinical encounter through the mechanisms of the placebo effect.
G. Castelnuovo+48 more
semanticscholar +1 more source