Results 181 to 190 of about 523,100 (300)

Hepatocyte PIEZO1 Negatively Regulates Lipogenesis and Ameliorates MASLD by Sensing Membrane Tension and Activating AMPK

Advanced Science, EarlyView.
Hepatocytes are subjected to increased membrane tension along with lipid accumulation. Loss of PIEZO1 exacerbates high‐fat diet‐induced MASLD in mice. Activation of PIEZO1 alleviates high‐fat diet‐induced MASLD in mice. PIEZO1 negatively regulates de novo lipogenesis through activation of CaMKK2‐AMPK pathway. ABSTRACT Liver is a central organ for lipid
Hui Chen, Qimeng Wang, Ke Yang, Qinghai Lian, Xuyun Peng, Zhiyong Gong, Xinyi Zhao, Yong Wu, Tian Tao, Siqi Xu, Yifan Chen, Xiaoyan Tang, Jinghui Guo, Geyang Xu, Qi Zhang   +14 more
wiley   +1 more source

Association of plant-based diet with the risk of large-for-gestational-age birth in women with gestational diabetes mellitus. [PDF]

Nutr Metab (Lond)
Yin Y, Ye M, Shi M, Miao Z, Wang X, Lu S, Wu Y, Hu W, Fu Y.   +8 more
europepmc   +1 more source

A Testis‐Specific Aralkylamine N‐Acetyltransferase Regulates Dimorphic Sperm Function and Male Fertility in Moths

Advanced Science, EarlyView.
We identify a Lepidoptera‐conserved testis‐specific arylalkylamine N‐acetyltransferase (LTNAT) that governs male moth fertility via a novel mechanism. LTNAT loss disrupts eupyrene sperm mitochondrial derivatives and impairs apyrene sperm motility, offering a safe molecular target for innovative pesticides and genetic pest control.
Hao Sun, Peng‐Yi Huang, Zhi‐Ruo Zhang, Cong‐Fen Gao, Subba Reddy Palli, Shun‐Fan Wu   +5 more
wiley   +1 more source

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

A High-Fiber, Plant-Based Diet in Myeloma Precursor Disorders: Results from the NUTRIVENTION Clinical Trial and Preclinical Vk*MYC Model. [PDF]

Cancer Discov
Shah UA, Cogrossi LL, Garcés JJ, Policastro A, Castro F, Derkach A, Fei T, DeWolf S, Grioni M, Sisti S, Blaslov J, Adintori PA, Hosszu KK, McAvoy D, Baichoo M, Cross JR, Paredes J, Anuraj A, Raj SS, Pohl C, Zordan P, Zinsmeyer V, Jesus Faustino Ramos RJ, Lorenzoni M, Gipson B, Maclachlan KH, Gradissimo A, Boiocchi L, Aleynick N, Marchigiani C, Pagani S, Salehi E, Koche RP, Chaligne R, Block T, Korde N, Tan CR, Hultcrantz M, Hassoun H, Shah GL, Scordo M, Lahoud OB, Chung DJ, Landau HJ, Peled JU, Clementi N, Chesi M, Bergsagel PL, Mailankody S, Pollak MN, D'Souza A, Landgren O, Chimonas S, Giralt SA, Usmani SZ, Iyengar NM, Lesokhin AM, van den Brink MRM, Bellone M.   +58 more
europepmc   +1 more source

Alternating High‐Fat and Polysaccharide Diets Modulates Gut Phage‐Bacterial Interplay

Advanced Science, EarlyView.
This study reveals how alternating high‐fat and polysaccharide diets reshape the human gut virome and enhance phage‐bacteria interactions. Using large‐scale metagenomic meta‐analysis and a time‐resolved mouse model, the authors show that diets strongly modulate phage abundance, lifestyle, and gene exchange, offering new insights into nutrition‐guided ...
Fengxiang Zhao, Ruiqi Zhang, Rujun Wei, Huimin Fan, Yongfei Hu, Wenyu Shi, Jinfeng Wang   +6 more
wiley   +1 more source

Long-Term Air Pollution Exposure, Plant-based Diet, and Asthma Exacerbations in the Nurses' Health Study II. [PDF]

Ann Am Thorac Soc
Wang JG, Li W, Liu B, Varraso R, Wharton R, Ponce J, Hart JE, Camargo CA, Hanson C, Bose S.   +9 more
europepmc   +1 more source

Maternal Preconception Antibiotic Exposure Disrupts Microbial Succession: A Transgenerational Risk for Offspring Gut Mucosal Immaturity and Colitis Susceptibility

Advanced Science, EarlyView.
This study reveals that maternal antibiotic exposure prior to conception disrupts intergenerational gut microbial succession. By enhancing maternal‐offspring microbial transmission, altering microbial developmental trajectories and increasing selective pressures during community assembly, these disturbances lead to persistent gut mucosal immaturity and
Yuzhu Chen, Ruqiao Duan, Cunzheng Zhang, Gaonan Li, XiaoLin Ji, Qi Zhang, Fei Pei, Kun Wang, Liping Duan   +8 more
wiley   +1 more source

The Relationship Between Plant-Based Diet Index and Quality of Life, Serum Levels of Pentraxin-3, and Handgrip Strength in Patients on Maintenance Hemodialysis. [PDF]

Food Sci Nutr
Ghaedi S, Foshati S, Babajafari S, Navab F, Gholaminejad A, Mortazavi M, Rouhani MH.   +6 more
europepmc   +1 more source

Genome‐Wide Association Study Reveals Insect Genetics and Microbial Symbiont Effects on Susceptibility of Diaphorina citri to the Citrus Greening Pathogen, Candidatus Liberibacter Asiaticus

Advanced Science, EarlyView.
This study investigates the genetic and microbial factors influencing the susceptibility of Diaphorina citri to the citrus greening pathogen Candidatus Liberibacter asiaticus (CLas), employing a microbiome Genome Wide Association Study. The research identifies a key gene encoding an MFS‐type transporter contributing to CLas infectivity and abundance in
Kai Liu, Qingcui He, Zeyue Lin, Shixuan Huang, Zichun Zhong, Pingyang Zhu, Mengge Gao, Luyao Zhao, Han Jin, Guiting Wu, Gurr M. Geoff, Qunxin Han, Rui Pang   +12 more
wiley   +1 more source