LncRNAs as Regulators of Atherosclerotic Plaque Stability [PDF]
Cells, 2023 Current clinical data show that, despite constant efforts to develop novel therapies and clinical approaches, atherosclerotic cardiovascular diseases (ASCVD) are still one of the leading causes of death worldwide.
Aleksa Petkovic +10 more
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Gut Microbiota and Atherosclerosis—Focusing on the Plaque Stability [PDF]
Frontiers in Cardiovascular Medicine, 2021 Cardiovascular diseases (CVDs) are major causes of mortality and morbidity in the modern society. The rupture of atherosclerotic plaque can induce thrombus formation, which is the main cause of acute cardiovascular events.
Xinyi Shen +6 more
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Exosomal circSCMH1/miR-874 ratio in serum to predict carotid and coronary plaque stability [PDF]
Frontiers in Cardiovascular Medicine, 2023 BackgroundTo investigate the correlation between lg (circSCMH1/miR-874) and acute coronary syndrome (ACS), acute myocardial infarction (AMI), and carotid plaque stability.Methods701 patients were divided into stable coronary artery disease (SCAD), ACS ...
Jiayu Wang +8 more
doaj +4 more sources
The Role of Hydrogen Sulfide in Plaque Stability [PDF]
Antioxidants, 2022 Atherosclerosis is the greatest contributor to cardiovascular events and is involved in the majority of deaths worldwide. Plaque rapture or erosion precipitates life-threatening thrombi, resulting in the obstruction blood flow to the heart (acute ...
Qian Lin, Bin Geng
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Plaque stability and plaque regression: new insights [PDF]
European Heart Journal Supplements, 2006 Patients with prior cardiovascular disease and/or diabetes are at the highest risk of a myocardial infarction or stroke. Thus, the majority of morbid cardiovascular events arise in the large population of patients with qualifying risk factors, according to standard risk factor scoring techniques.
Diethelm Tschoepe, Bernd Stratmann
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Neutrophil-specific STAT4 deficiency attenuates atherosclerotic burden and improves plaque stability via reduction in neutrophil activation and recruitment into aortas of Ldlr−/− mice [PDF]
Frontiers in Cardiovascular Medicine, 2023 Background and aimsNeutrophils drive atheroprogression and directly contribute to plaque instability. We recently identified signal transducer and activator of transcription 4 (STAT4) as a critical component for bacterial host defense in neutrophils. The
W. Coles Keeter +10 more
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Relation of Plaque Lipid Composition and Morphology to the Stability of Human Aortic Plaques [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 1997 Abstract The propensity of atherosclerotic plaques to disrupt may be influenced by their lipid content and the distribution of these lipids within the plaque. To investigate this, we analyzed the morphological and lipid profiles of 668 human aortic plaques from 30 males who had died of ischemic heart disease.
Carl V. Felton +3 more
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Ginsenoside Rb1 Enhances Plaque Stability and Inhibits Adventitial Vasa Vasorum via the Modulation of miR-33 and PEDF [PDF]
Frontiers in Cardiovascular Medicine, 2021 Background: Atherosclerosis is closely associated with proliferation of the adventitial vasa vasorum, leading to the atherosclerotic plaque progression and vulnerability.
Xiaoyan Yang +20 more
doaj +2 more sources
Tongxinluo May Alleviate Inflammation and Improve the Stability of Atherosclerotic Plaques by Changing the Intestinal Flora [PDF]
Frontiers in Pharmacology, 2022 Intestinal flora plays an important role in atherosclerosis. Tongxinluo, as a multi-target Chinese medicine to improve atherosclerosis, whether it can improve atherosclerosis by affecting the intestinal flora is worth exploring.
Yan Qi +11 more
doaj +2 more sources
Non-HDL-C/HDL-C ratio is associated with carotid plaque stability in general population: A cross-sectional study [PDF]
Frontiers in Neurology, 2022 BackgroundCarotid atherosclerosis, especially the rupture of unstable plaques, plays an important role in the development of stroke. A novel lipid ratio, the non-high-density lipoprotein cholesterol (non-HDL-C)/high-density lipoprotein cholesterol (HDL-C)
Anran Wang +13 more
doaj +2 more sources