Results 41 to 50 of about 78,612 (185)

Protease-Activated Receptor-2 Deficiency Attenuates Atherosclerotic Lesion Progression and Instability in Apolipoprotein E-Deficient Mice

Frontiers in Pharmacology, 2017
Inflammatory mechanisms are involved in the process of atherosclerotic plaque formation and rupture. Accumulating evidence suggests that protease-activated receptor (PAR)-2 contributes to the pathophysiology of chronic inflammation on the vasculature. To
Pengfei Zuo, Zhi Zuo, Yueyue Zheng, Xin Wang, Qianxing Zhou, Long Chen, Genshan Ma   +6 more
doaj   +1 more source

Endothelial-to-Mesenchymal Transition in Atherosclerosis: Friend or Foe?

Cells, 2022
Despite many decades of research, complications of atherosclerosis resulting from the rupture or erosion of unstable plaques remain the leading cause of death worldwide.
Sarin Gole, Svyatoslav Tkachenko, Tarek Masannat, Richard A. Baylis, Olga A. Cherepanova   +4 more
doaj   +1 more source

DOT1L regulates lipid biosynthesis and inflammatory responses in macrophages and promotes atherosclerotic plaque stability

, 2022
Macrophages are critical immune cells in inflammatory diseases, and their differentiation and function are tightly regulated by histone modifications. H3K79 methylation is a histone modification associated with active gene expression, and DOT1L is the ...
de Winther, Menno P J, Gijbels, Marion, van Roomen, Cindy P. A. A., Zelcer, Noam, Bosmans, Laura A., Beckers, Linda, Neele, Annette E, Jacobs, Heinz, Toom, Myrthe den, Bosmans, Laura A, Prange, Koen H. M., Willemsen, Lisa, van Leeuwen, Fred, Spann, Nathanael J, Neele, Annette E., Prange, Koen H M, Griffith, Guillermo R, Spann, Nathanael J., van Wouw, Suzanne, Griffith, Guillermo R., Siebeler, Ricky, de Winther, Menno P. J., Gorbatenko, Andrej, van Roomen, Cindy P A A, Chen, Hung-Jen   +24 more
core   +1 more source

The E3 Ubiquitin Ligase Peli1 Deficiency Promotes Atherosclerosis Progression

Cells, 2022
Background: Atherosclerosis is a chronic inflammatory vascular disease and the main cause of death and morbidity. Emerging evidence suggests that ubiquitination plays an important role in the pathogenesis of atherosclerosis including control of vascular ...
Fabienne Burger, Daniela Baptista, Aline Roth, Karim J. Brandt, Kapka Miteva   +4 more
doaj   +1 more source

Huang-Lian-Jie-Du Decoction Attenuates Atherosclerosis and Increases Plaque Stability in High-Fat Diet-Induced ApoE-/- Mice by Inhibiting M1 Macrophage Polarization and Promoting M2 Macrophage Polarization

Frontiers in Physiology, 2021
Macrophage polarization plays a vital impact in triggering atherosclerosis (AS) progression and regression. Huang-Lian-Jie-Du Decoction (HLJDD), a famous traditional Chinese decoction, displays notable anti-inflammatory and lipid-lowering effects in ...
Yinhe Cai, Junmao Wen, Siwen Ma, Zhexing Mai, Qunzhang Zhan, Yijun Wang, Yueyao Zhang, He Chen, Haiyi Li, Wei Wu, Rong Li, Chuanjin Luo   +11 more
doaj   +1 more source

Triglyceride-Glucose Index Is Related to Carotid Plaque and Its Stability in Nondiabetic Adults: A Cross-Sectional Study

Frontiers in Neurology, 2022
BackgroundCarotid plaque plays an important role in the development of stroke. The triglyceride-glucose (TyG) index is a reliable alternative marker of insulin resistance.
Anran Wang, Yapeng Li, Lue Zhou, Kai Liu, Shaohua Li, Bo Song, Yuan Gao, Yusheng Li, Jie Lu, Chuansheng Tian, Yuming Xu, Longde Wang, Longde Wang   +12 more
doaj   +1 more source

The Effects of Using Plaque-Disclosing Tablets on the Removal of Plaque and Gingival Status of Orthodontic Patients [PDF]

, 2019
Objective:The aim of this study was to investigate the effects of using plaque-disclosing tablets (PDTs) on the plaque and gingival index scores of patients wearing fixed orthodontic appliances.Methods:In group A (n=16), the subjects were motivated by ...
Oral Sökücü, Mehmet Ali Yavan, Serhat Özdemir, Sayad Kocahan   +3 more
core   +1 more source

Nkx2‐5 Is Expressed in Atherosclerotic Plaques and Attenuates Development of Atherosclerosis in Apolipoprotein E–Deficient Mice

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
Background NK2 homeobox 5 (Nkx2‐5) is a cardiac homeobox transcription factor that is expressed in a broad range of cardiac sublineages. Embryos lacking Nkx2‐5 are nonviable attributed to growth retardation and gross abnormalities of the heart.
Meng Du, Xiaojing Wang, Xin Tan, Xiangrao Li, Dandan Huang, Kun Huang, Liu Yang, Fengxiao Zhang, Yan Wang, Dan Huang, Kai Huang   +10 more
doaj   +1 more source

The Complementary Effects of Dabigatran Etexilate and Exercise Training on the Development and Stability of the Atherosclerotic Lesions in Diabetic ApoE Knockout Mice

Pharmaceuticals, 2023
Aim: To determine the complementary effects of dabigatran etexilate (DE), exercise training (ET), and combination (DE + ET) on the development and stability of the atherosclerotic lesions in diabetic apoE knockout (apoE−/−) mice. Methods: In 48 male apoE−
Nikolaos PE Kadoglou, Marianna Stasinopoulou, Evangelia Gkougkoudi, Eirini Christodoulou, Nikolaos Kostomitsopoulos, Georgia Valsami   +5 more
doaj   +1 more source

Increases of Corporal Temperature as a Risk Factor of Atherosclerotic Plaque Instability

, 2008
This work explores for the first time the effects of temperature increments on the development of high shear stresses between plaque and arterial wall due to their different dilatational properties. Data from the literature report febrile reactions prior
Rojo Pérez, Francisco Javier, Elices, Margarita L., Gonzalez, Pablo, Ortega Pozzi, Aranzazu, Elices Calafat, Manuel, Torres Coronado, Monica, Guinea Tortuero, Gustavo V., Fantidis, Panayotis, Atienza Riera, José Miguel, Hayashi, Kozaburo   +9 more
core   +1 more source