Results 41 to 50 of about 2,493,525 (282)
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016 Background NK2 homeobox 5 (Nkx2‐5) is a cardiac homeobox transcription factor that is expressed in a broad range of cardiac sublineages. Embryos lacking Nkx2‐5 are nonviable attributed to growth retardation and gross abnormalities of the heart.
Meng Du +10 more
doaj +1 more source
Biomechanical factors and macrophages in plaque stability [PDF]
Cardiovascular Research, 2013 Thin-cap fibroatheromas (TCFAs) or vulnerable atherosclerotic plaques are considered a high-risk phenotype for acute cardiovascular events. TCFAs are identified by a thin rupture-prone fibrous cap, a large necrotic core, and a high content of leucocytes. Atherogenesis is dependent upon complex patterns of blood flow.
Seneviratne, A +3 more
openaire +2 more sources
Journal of Lipid Research, 2010 We recently reported that oxidized LDL (oxLDL) induces an oscillatory increase in intracellular calcium ([Ca2+]i) levels in macrophages. Furthermore, we have shown that these [Ca2+]i oscillations mediate oxLDL's ability to inhibit macrophage apoptosis in
Johnny H. Chen +5 more
doaj +1 more source
Pharmaceuticals, 2023 Aim: To determine the complementary effects of dabigatran etexilate (DE), exercise training (ET), and combination (DE + ET) on the development and stability of the atherosclerotic lesions in diabetic apoE knockout (apoE−/−) mice. Methods: In 48 male apoE−
Nikolaos PE Kadoglou +5 more
doaj +1 more source
Stability Analysis of a Model of Atherosclerotic Plaque Growth [PDF]
Computational and Mathematical Methods in Medicine, 2015 Atherosclerosis, the formation of life-threatening plaques in blood vessels, is a form of cardiovascular disease. In this paper, we analyze a simplified model of plaque growth to derive physically meaningful results about the growth of plaques. In particular, the main results of this paper are two conditions, which express that the immune response ...
Sushruth Reddy, Padmanabhan Seshaiyer
openaire +2 more sources
Effects of platelet microparticles on atherosclerotic plaque formation and stability in ApoE-/- mice
Di-san junyi daxue xuebao, 2019 Objective To investigate the effect of platelet microparticles (PMPs) from C57BL/6 mice on atherosclerotic plaque formation and plaque stability in apolipoprotein E knockout (ApoE-/-) mice.
WANG Zeyang +4 more
doaj +1 more source
Journal of Lipid Research, 2013 Lysophosphatidic acid (LPA), a bioactive lysophospholipid, accumulates in the atherosclerotic plaque. It has the capacity to activate mast cells, which potentially exacerbates plaque progression.
Martine Bot +9 more
doaj +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source