Results 31 to 40 of about 2,493,525 (282)

Neutrophil-specific STAT4 deficiency attenuates atherosclerotic burden and improves plaque stability via reduction in neutrophil activation and recruitment into aortas of Ldlr−/− mice

Frontiers in Cardiovascular Medicine, 2023
Background and aimsNeutrophils drive atheroprogression and directly contribute to plaque instability. We recently identified signal transducer and activator of transcription 4 (STAT4) as a critical component for bacterial host defense in neutrophils. The
W. Coles Keeter, Alina K. Moriarty, Alina K. Moriarty, Rachel Akers, Rachel Akers, Shelby Ma, Marion Mussbacher, Marion Mussbacher, Jerry L. Nadler, Elena V. Galkina, Elena V. Galkina   +10 more
doaj   +1 more source

Stabilization of atherosclerotic plaques: an update [PDF]

European Heart Journal, 2013
The majority of coronary thrombi (∼75%) is caused by plaque rupture .1,2 Prototype of the rupture-prone plaque contains a large, soft, lipid-rich necrotic core with a thin and inflamed fibrous cap, so-called thin-cap fibroatheroma (TCFA) ( Figure 1 ).3,4 Other common features include expansive remodelling, large plaque size, plaque haemorrhage ...
Yla-Herttuala, S., Bentzon, J.F., Daemen, M., Falk, E., Garcia-Garcia, H.M., Herrmann, J., Hoefer, I., Jauhiainen, S., Jukema, J.W., Krams, R., Kwak, B.R., Marx, N., Naruszewicz, M., Newby, A., Pasterkamp, G., Serruys, P.W.J.C., Waltenberger, J., Weber, C., Tokgozoglu, L., ESC Working Grp Atherosclerosis Va   +19 more
openaire   +6 more sources

Increases of Corporal Temperature as a Risk Factor of Atherosclerotic Plaque Instability [PDF]

, 2008
This work explores for the first time the effects of temperature increments on the development of high shear stresses between plaque and arterial wall due to their different dilatational properties. Data from the literature report febrile reactions prior
Rojo Pérez, Francisco Javier, Elices, Margarita L., Gonzalez, Pablo, Ortega Pozzi, Aranzazu, Elices Calafat, Manuel, Torres Coronado, Monica, Guinea Tortuero, Gustavo V., Fantidis, Panayotis, Atienza Riera, José Miguel, Hayashi, Kozaburo   +9 more
core   +1 more source

Ultra-short echo time cardiovascular magnetic resonance of atherosclerotic carotid plaque [PDF]

, 2010
Background Multi-contrast weighted cardiovascular magnetic resonance (CMR) allows detailed plaque characterisation and assessment of plaque vulnerability.
Sonia Nielles-Vallespin, Nielles-Vallespin, S, Firmin, DN, Chan, Cheuk F, Keenan, Niall G, Mary N Sheppard, Gatehouse, Peter, Chan Cheuk F, Firmin David N, Gatehouse, P, Keenan, NG, Sheppard, MN, Boyle, JJ, Peter Gatehouse, Chan, CF, Sheppard Mary N, Boyle Joseph J, Joseph J Boyle, Niall G Keenan, Nielles-Vallespin, Sonia, Boyle, Joseph J, Sheppard, Mary N, Pennell, Dudley J, Pennell, DJ, Pennell Dudley J, Gatehouse Peter, Dudley J Pennell, Nielles-Vallespin Sonia, David N Firmin, Cheuk F Chan, Keenan Niall G, Firmin, David N   +31 more
core   +1 more source

Klotho protects against chronic kidney disease-associated atherosclerotic plaque vulnerability in

Di-san junyi daxue xuebao, 2020
Objective To explore the effects of chronic kidney disease (CKD) on the instability of atherosclerotic plaques and investigate the role of Klotho in this pathological process.
BI Xianjin, YANG Jiangxin, XIONG Jiachuan, YANG Ke, ZHAO Jinghong   +4 more
doaj   +1 more source

Protease-Activated Receptor-2 Deficiency Attenuates Atherosclerotic Lesion Progression and Instability in Apolipoprotein E-Deficient Mice

Frontiers in Pharmacology, 2017
Inflammatory mechanisms are involved in the process of atherosclerotic plaque formation and rupture. Accumulating evidence suggests that protease-activated receptor (PAR)-2 contributes to the pathophysiology of chronic inflammation on the vasculature. To
Pengfei Zuo, Zhi Zuo, Yueyue Zheng, Xin Wang, Qianxing Zhou, Long Chen, Genshan Ma   +6 more
doaj   +1 more source

How to stabilize unstable plaque [PDF]

Cardiovascular Research, 2011
This editorial refers to ‘Inhibition of rupture of established atherosclerotic plaques by treatment with apolipoprotein A-I’ by G.J. Reimers et al. , doi:10.1093/cvr/cvr057 Association studies and epidemiological observations have shown that high plasma levels of high-density lipoprotein-cholesterol (HDL-C) provide cardiovascular protection.1 The ...
openaire   +2 more sources

Endothelial-to-Mesenchymal Transition in Atherosclerosis: Friend or Foe?

Cells, 2022
Despite many decades of research, complications of atherosclerosis resulting from the rupture or erosion of unstable plaques remain the leading cause of death worldwide.
Sarin Gole, Svyatoslav Tkachenko, Tarek Masannat, Richard A. Baylis, Olga A. Cherepanova   +4 more
doaj   +1 more source

The E3 Ubiquitin Ligase Peli1 Deficiency Promotes Atherosclerosis Progression

Cells, 2022
Background: Atherosclerosis is a chronic inflammatory vascular disease and the main cause of death and morbidity. Emerging evidence suggests that ubiquitination plays an important role in the pathogenesis of atherosclerosis including control of vascular ...
Fabienne Burger, Daniela Baptista, Aline Roth, Karim J. Brandt, Kapka Miteva   +4 more
doaj   +1 more source

Huang-Lian-Jie-Du Decoction Attenuates Atherosclerosis and Increases Plaque Stability in High-Fat Diet-Induced ApoE-/- Mice by Inhibiting M1 Macrophage Polarization and Promoting M2 Macrophage Polarization

Frontiers in Physiology, 2021
Macrophage polarization plays a vital impact in triggering atherosclerosis (AS) progression and regression. Huang-Lian-Jie-Du Decoction (HLJDD), a famous traditional Chinese decoction, displays notable anti-inflammatory and lipid-lowering effects in ...
Yinhe Cai, Junmao Wen, Siwen Ma, Zhexing Mai, Qunzhang Zhan, Yijun Wang, Yueyao Zhang, He Chen, Haiyi Li, Wei Wu, Rong Li, Chuanjin Luo   +11 more
doaj   +1 more source