Results 51 to 60 of about 78,612 (185)

Sphingosine kinase regulates oxidized low density lipoprotein-mediated calcium oscillations and macrophage survival

Journal of Lipid Research, 2010
We recently reported that oxidized LDL (oxLDL) induces an oscillatory increase in intracellular calcium ([Ca2+]i) levels in macrophages. Furthermore, we have shown that these [Ca2+]i oscillations mediate oxLDL's ability to inhibit macrophage apoptosis in
Johnny H. Chen, Maziar Riazy, Shih Wei Wang, Jiazhen Minnie Dai, Vincent Duronio, Urs P. Steinbrecher   +5 more
doaj   +1 more source

Effects of platelet microparticles on atherosclerotic plaque formation and stability in ApoE-/- mice

Di-san junyi daxue xuebao, 2019
Objective To investigate the effect of platelet microparticles (PMPs) from C57BL/6 mice on atherosclerotic plaque formation and plaque stability in apolipoprotein E knockout (ApoE-/-) mice.
WANG Zeyang, WANG Zeyang, PAN Lina, CHEN Liyuan, HU Houyuan   +4 more
doaj   +1 more source

Stability Analysis of a Model of Atherosclerotic Plaque Growth [PDF]

Computational and Mathematical Methods in Medicine, 2015
Atherosclerosis, the formation of life-threatening plaques in blood vessels, is a form of cardiovascular disease. In this paper, we analyze a simplified model of plaque growth to derive physically meaningful results about the growth of plaques. In particular, the main results of this paper are two conditions, which express that the immune response ...
Sushruth Reddy, Padmanabhan Seshaiyer
openaire   +2 more sources

How critical is fibrous cap thickness to carotid plaque stability? A flow-plaque interaction model

, 2006
Background and Purpose \ud \ud Acute cerebral ischemic events are associated with rupture of vulnerable carotid atheroma and subsequent thrombosis. Factors such as luminal stenosis and fibrous cap thickness have been thought to be important risk factors ...
Tang, T., Z.-Y. Li, Howarth, S. P. S., Li, Z. Y., S. P.S. Howarth, J. H. Gillard, T. Tang, Gillard, J. H.   +7 more
core   +1 more source

Lysophosphatidic acid triggers mast cell-driven atherosclerotic plaque destabilization by increasing vascular inflammation[S]

Journal of Lipid Research, 2013
Lysophosphatidic acid (LPA), a bioactive lysophospholipid, accumulates in the atherosclerotic plaque. It has the capacity to activate mast cells, which potentially exacerbates plaque progression.
Martine Bot, Saskia C.A. de Jager, Luke MacAleese, H. Maxime Lagraauw, Theo J.C. van Berkel, Paul H.A. Quax, Johan Kuiper, Ron M.A. Heeren, Erik A.L. Biessen, Ilze Bot   +9 more
doaj   +1 more source

Inhibition of PFKFB3 Hampers the Progression of Atherosclerosis and Promotes Plaque Stability

Frontiers in Cell and Developmental Biology, 2020
Aims6-phosphofructo-2-kinase/fructose-2,6-biphosphatase (PFKFB)3-mediated glycolysis is pivotal in driving macrophage- and endothelial cell activation and thereby inflammation.
Kikkie Poels, Johan G. Schnitzler, Farahnaz Waissi, Farahnaz Waissi, Farahnaz Waissi, Johannes H. M. Levels, Erik S. G. Stroes, Mat J. A. P. Daemen, Esther Lutgens, Esther Lutgens, Esther Lutgens, Anne-Marije Pennekamp, Dominique P. V. De Kleijn, Dominique P. V. De Kleijn, Dominique P. V. De Kleijn, Tom T. P. Seijkens, Jeffrey Kroon   +16 more
doaj   +1 more source

Genetic deletion or TWEAK blocking antibody administration reduce atherosclerosis and enhance plaque stability in mice

, 2014
Clinical complications associated with atherosclerotic plaques arise from luminal obstruction due to plaque growth or destabilization leading to rupture. Tumour necrosis factor ligand superfamily member 12 (TNFSF12) also known as TNF-related weak inducer
Sastre, Cristina, Llamas‐Granda, Patricia, Egido, Jesús, Blanco‐Colio, Luis, Fernández‐Laso, Valvanera, Madrigal‐Matute, Julio, Pastor Vargas, Carlos, Martín‐Ventura, José, Muñoz‐García, Begoña, Burkly, Linda, Moreno, Juan   +10 more
core   +1 more source

Carotid Artery Calcification Features in Plaque Stability and Clinical Events [PDF]

Zhongguo quanke yixue
Carotid atherosclerosis is a degenerative disease that is a hemodynamic change caused by endothelial dysfunction and is an important cause of stroke, and the assessment of plaque stability plays an important role in predicting future clinical events ...
CHU Tianyu, GU Yan
doaj   +1 more source

Oxidative Stress and Coronary Plaque Stability [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2002
Increased production of reactive oxygen species (ROS) in the vascular wall is a characteristic feature of disease states, including atherosclerosis, diabetes and hypertension. ROS, such as superoxide, reduce nitric oxide bioactivity by scavenging and cause oxidation of lipids and target proteins. In addition, recent work has revealed that ROS mediate a
openaire   +2 more sources

Heterogeneity of atherosclerotic plaque macrophage origin, phenotype and functions: Implications for treatment

, 2017
Macrophages are key players in atherosclerotic lesions, regulating the local inflammatory milieu and plaque stability by the secretion of many inflammatory molecules, growth factors and cytokines. Monocytes have long been considered to be the main source
Nagenborg, Jan, Donners, Marjo M. P. C., Jan Nagenborg, Goossens, Pieter, Biessen, Erik A. L., Erik A.L. Biessen, Donners, Marjo M P C., Marjo M.P.C. Donners, Biessen, Erik A L., Biessen, Erik A. L.; id_orcid, Pieter Goossens   +10 more
core   +1 more source