Results 61 to 70 of about 78,612 (185)

Anti-Atherosclerosis Effect of Angong Niuhuang Pill via Regulating Th17/Treg Immune Balance and Inhibiting Chronic Inflammatory on ApoE-/- Mice Model of Early and Mid-Term Atherosclerosis

Frontiers in Pharmacology, 2020
Angong Niuhuang Pill (ANP) is a well-known patented Chinese medicine which is used for hundreds of years for treating the central nervous system diseases. Atherosclerosis is a poly-aetiological chronic inflammatory vascular disease.
Qinghong Fan, Yujuan Liu, Jiaoyu Rao, Zhe Zhang, Wei Xiao, Tao Zhu, Xiaomeng Chai, Kaihe Ye, Na Ning, Zhen Yin, Yushuang Chai, Yimin Xu, Ruirui Lan, A Verkhratsky, Hong Nie, Hong Nie   +15 more
doaj   +1 more source

"VEGFR2 blockade in murine atherosclerotic vein grafts enhances plaque stability and reduces intraplaque haemorrhage by enhancement of plaque neovessel maturation"

, 2016
Blockade of VEGFR2 normalizes the unbridled process of plaque neovessel formation and induces maturation of nascent vessels resulting in prevention of intraplaque haemorrhage and influx of inflammatory cells into the plaque and subsequently increases ...
Parma, Laura (5939768), Hamming, Jaap (5944115), Goumans, Marie -José, Quax, Paul (5944121), Quax, Paul, Parma, Laura, Peters, Erna, De Vries, Margreet (5944109), De Vries, Margreet, Peters, Erna (5944112), Hamming, Jaap, Goumans, Marie -José (5944118)   +11 more
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Tongxinluo May Alleviate Inflammation and Improve the Stability of Atherosclerotic Plaques by Changing the Intestinal Flora

Frontiers in Pharmacology, 2022
Intestinal flora plays an important role in atherosclerosis. Tongxinluo, as a multi-target Chinese medicine to improve atherosclerosis, whether it can improve atherosclerosis by affecting the intestinal flora is worth exploring.
Yan Qi, Wenzhao Liu, Xuefang Yan, Chen Zhang, Chunmei Zhang, Lingxin Liu, Xuehui Zheng, Mengying Suo, Yun Ti, Mei Ni, Meng Zhang, Peili Bu   +11 more
doaj   +1 more source

SLC4A10 impedes atherosclerosis by diminishing IFN-γ/GZMB levels of CD8+ T cells via the MAPK pathway

Frontiers in Immunology
Background and aimsCD8+ T cell subpopulations participate in the formation of atherosclerotic plaques through activation or exhaustion. Yet, it is unclear which specific subset it critically involved.
Bo Chen, Bo Chen, Lei Zhu, Lei Zhu, Xueguang Lin, Xueguang Lin, Kristine J. S. Kwan, Kristine J. S. Kwan, Jie Wang, Jie Wang, Yijie Lu, Yijie Lu, Jialong Li, Jialong Li, Ying Deng, Ying Deng, Shuai Jiang, Shuai Jiang, Jingdong Tang, Jingdong Tang, Bo Yu, Bo Yu, Bo Yu   +22 more
doaj   +1 more source

Genetic loss of Gas6 induces plaque stability in experimental atherosclerosis

, 2008
El pdf del artículo es la versión pre-print.-- et al.The growth arrest-specific gene 6 (Gas6) plays a role in pro-atherogenic processes such as endothelial and leukocyte activation, smooth muscle cell migration and thrombosis, but its role in ...
García de Frutos, Pablo, Carmeliet, Peter   +1 more
core   +2 more sources

Extracellular traps from activated vascular smooth muscle cells drive the progression of atherosclerosis

Nature Communications, 2022
Vascular smooth muscle cells (VSMCs) are known for their fate plasticity in atherosclerosis plaque progression. Here, Zhai et al. show that extracellular traps generated from CD68 + VSMCs adversely contribute to plaque progression and highlight their ...
Ming Zhai, Shiyu Gong, Peipei Luan, Yefei Shi, Wenxin Kou, Yanxi Zeng, Jiayun Shi, Guanye Yu, Jiayun Hou, Qing Yu, Weixia Jian, Jianhui Zhuang, Mark W. Feinberg, Wenhui Peng   +13 more
doaj   +1 more source

Relation of Plaque Lipid Composition and Morphology to the Stability of Human Aortic Plaques [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 1997
AbstractThe propensity of atherosclerotic plaques to disrupt may be influenced by their lipid content and the distribution of these lipids within the plaque. To investigate this, we analyzed the morphological and lipid profiles of 668 human aortic plaques from 30 males who had died of ischemic heart disease.
C V, Felton, D, Crook, M J, Davies, M F, Oliver   +3 more
openaire   +2 more sources

Partial Inhibition of the 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase-3 (PFKFB3) Enzyme in Myeloid Cells Does Not Affect Atherosclerosis

, 2021
Background: The protein 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) is a key stimulator of glycolytic flux. Systemic, partial PFKFB3 inhibition previously decreased total plaque burden and increased plaque stability.
De Bruijn, J., Gijbels, M.J., Ghosheh, Yanal, Ley, K., Van Kuijk, Kim, Ghosheh, Y., Saez-Rodriguez, Julio, Temmerman, Lieve, Sluimer, Judith C., Perales-Paton, Javier, Perales-Paton, J., Gijbels, Marion J., Ley, Klaus, Saez-Rodriguez, J., Sluimer, J.C.; id_orcid, Tillie, Renee J.HA., De Bruijn, Jenny, Carmeliet, Peter, Sluimer, J.C., Temmerman, L., Carmeliet, P., Tillie, R.J.H.A., Van Kuijk, K.   +22 more
core   +1 more source

Tetramethylpyrazine and paeoniflorin combination (TMP-PF) alleviates atherosclerosis progress by reducing hyperlipemia and inhibiting plaque angiogenesis via the NR4A1/VEGFR2 pathway

Food Science and Human Wellness
Atherosclerosis remains a great threat to human health worldwide. Previous studies found that tetramethylpyrazine (TMP) and paeonif lorin (PF) combination (TMP-PF) exerts anti-atherosclerotic effects in vitro.
Rong Yuan, Qiqi Xin, Weili Shi, Yu Miao, Zhengchuan Zhu, Yahui Yuan, Ying Chen, Xiaoning Chen, Sean Xiao Leng, Keji Chen, Weihong Cong   +10 more
doaj   +1 more source

Cysteine residues in the cytoplasmic carboxy terminus of connexins dictate gap junction plaque stability

, 2017
Gap junctions are cellular contact sites composed of clustered connexin transmembrane proteins that act in dual capacities as channels for direct intercellular exchange of small molecules and as structural adhesion complexes known as gap junction ...
Randy F. Stout, David C. Spray
core   +1 more source