Results 81 to 90 of about 78,612 (185)

Clinical significance of macrophage phenotypes in cardiovascular disease

Clinical and Translational Medicine, 2014
The emerging understanding of macrophage subsets and their functions in the atherosclerotic plaque has led to the consensus that M1 macrophages are pro‐atherogenic while M2 macrophages may promote plaque stability, primarily though their tissue repair ...
Heather J Medbury, Helen Williams, John P Fletcher   +2 more
doaj   +1 more source

The mechanical triggers of plaque rupture: Shear stress vs pressure gradient

, 2009
The aim of this study was to evaluate the mechanical triggers that may cause plaque rupture. Wall shear stress (WSS) and pressure gradient are the direct mechanical forces acting on the plaque in a stenotic artery.
Tang, T., Li, Z. Y., Sadat, U., Graves, M., Taviani, V., Gillard, J. H., Patterson, A., Young, V.   +7 more
core   +1 more source

Acute perioperative-stress-induced increase of atherosclerotic plaque volume and vulnerability to rupture in apolipoprotein-E-deficient mice is amenable to statin treatment and IL-6 inhibition

Disease Models & Mechanisms, 2015
Myocardial infarction and stroke are frequent after surgical procedures and consume a considerable amount of benefit of surgical therapy. Perioperative stress, induced by surgery, is composed of hemodynamic and inflammatory reactions.
Henrike Janssen, Christian S. Wagner, Philipp Demmer, Simone Callies, Gesine Sölter, Houra Loghmani-khouzani, Niandan Hu, Harald Schuett, Uwe J. F. Tietge, Gregor Warnecke, Jan Larmann, Gregor Theilmeier   +11 more
doaj   +1 more source

Prolonged Hyperoxygenation Treatment Improves Vein Graft Patency and Decreases Macrophage Content in Atherosclerotic Lesions in ApoE3*Leiden Mice

, 2020
Unstable atherosclerotic plaques frequently show plaque angiogenesis which increases the chance of rupture and thrombus formation leading to infarctions. Hypoxia plays a role in angiogenesis and inflammation, two processes involved in the pathogenesis of
de Vries, Margreet R., Vries, M.R. de, Quax, Paul H. A., Quax, P.H.A., Peters, Hendrika A. B., Parma, L., Peters, H.A.B., Sluimer, Judith C., Paul H.A. Quax, Fabiana Baganha, Margreet R. de Vries, Sluimer, Judith C.; id_orcid, Laura Parma, Parma, Laura, Baganha, Fabiana, Judith C. Sluimer, Sluimer, J.C., Hendrika A. B. Peters, Baganha, F.   +18 more
core   +1 more source

Biomechanics of atherosclerotic coronary plaque: site, stability and in vivo elasticity modeling.

, 2013
International audienceCoronary atheroma develop in local sites that are widely variable among patients and are considerably variable in their vulnerability for rupture.
Heroux, Julie, Guy Cloutier, Cloutier, Guy, Finet, Gérard, Simon Le Floc’h, Julie Heroux, Jacques Ohayon, Ohayon, Jacques, Pettigrew, Roderic I., Le Floc’h, Simon, Gharib, Ahmed M., Ahmed M. Gharib, Roderic I. Pettigrew   +12 more
core   +1 more source

Matrix Gla Protein, Plaque Stability, and Cardiovascular Events in Patients with Severe Atherosclerotic Disease

, 2018
OBJECTIVE: This study aims to investigate whether plasma matrix Gla protein (MGP) species, desphospho-uncarboxylated (dp-uc) MGP, and total uncarboxylated (t-uc) MGP are associated with plaque levels of uncarboxylated (uc) MGP, markers of plaque ...
Vermeer, Cees, den Ruijter, Hester M, den Ruijter, Hester M., Zwakenberg, Sabine R., van der Schouw, Yvonne T., Zwakenberg, Sabine R, van der Schouw, Yvonne T, Beulens, Joline W J, Beulens, Joline W. J., Pasterkamp, Gerard   +9 more
core   +1 more source

Association of Attenuated Plaques Detected by Intravascular Ultrasound With Plaque Calcification Assessed by Computed Tomography Angiography

Reviews in Cardiovascular Medicine
Background: Coronary artery calcium (CAC) reflects the overall atherosclerotic burden. The CAC density is inversely associated with plaque vulnerability.
Yang Zhao, Jiaying Li, Wenxuan Dou, Jingyao Yuan, Xin Huang   +4 more
doaj   +1 more source

Anti-Atherogenic Actions of Pomegranate Polyphenol Punicalagin and Its Metabolites: In Vitro Effects on Vascular Cells and In Vivo Atheroprotection by Urolithin A via Anti-Inflammatory and Plaque-Stabilising Mechanisms

Antioxidants
Nutraceuticals are emerging as promising agents for the prevention and treatment of atherosclerosis, particularly in light of the limitations associated with current pharmacotherapies. Pomegranate-derived polyphenols, especially punicalagin (PC), possess
Sulaiman Alalawi, Daniah Rifqi, Alaa Alhamadi, Reem Alotibi, Fahad Alradi, Nouf Alshehri, Yee-Hung Chan, Jing Chen, Faizah Albalawi, Sarab Taha, Nabras Al-Mahrami, Irina A. Guschina, Timothy R. Hughes, Dipak P. Ramji   +13 more
doaj   +1 more source

Mast cell chymase inhibition reduces atherosclerotic plaque progression and improves plaque stability in ApoE(-/-) mice

, 2010
Aims Mast cells have been shown to accumulate in the adventitia of human atherosclerotic plaques and were recently demonstrated by us to contribute to plaque progression and instability. In this study, we investigated whether selective inhibition of mast
Hartman, Peter, Sandra H. van Heiningen, Theo J.C. van Berkel, Hans Hilpert, Bot, Martine, van Santbrink, Peter J., Erik A.L. Biessen, Peter J. van Santbrink, Jürgen Fingerle, Fingerle, Juergen, van Berkel, Theo J. C., Lankhuizen, Inge M., Peter Hartman, Biessen, Erik A. L.; id_orcid, Gruener, Sabine, Martine Bot, Ilze Bot, Hilpert, Hans, Biessen, Erik A. L., Inge M. Lankhuizen, van Heiningen, Sandra H., Bot, Ilze, Sabine Gruener   +22 more
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S-propargyl-cysteine promotes the stability of atherosclerotic plaque via maintaining vascular muscle contractile phenotype [PDF]

Introduction: Plaque rupture in atherosclerosis contributes to various acute cardiovascular events. As a new sulfide-containing donor, S-propargyl-cysteine (SPRC) has been reported to play a beneficial role in cardioprotection, potentially through its ...
Li Zhi-Ming, Zhu Yi-Chun, Li Ping, Yu Bo, Zhang Bi-Shan, Zhu Lei, Wang Ming-Jie   +6 more
core   +1 more source