Results 21 to 30 of about 162,485 (319)

Chronic Stress A Potential Suspect Zero of Atherosclerosis: A Systematic Review

Frontiers in Cardiovascular Medicine, 2021
Atherosclerosis (AS) is a chronic vascular inflammatory disease, in which the lipid accumulation in the intima of the arteries shows yellow atheromatous appearance, which is the pathological basis of many diseases, such as coronary artery disease ...
Ling-bing Meng, Ling-bing Meng, Yuan-meng Zhang, Yue Luo, Tao Gong, De-ping Liu, De-ping Liu   +6 more
doaj   +1 more source

Stabilization of atherosclerotic plaques: an update [PDF]

European Heart Journal, 2013
The majority of coronary thrombi (∼75%) is caused by plaque rupture .1,2 Prototype of the rupture-prone plaque contains a large, soft, lipid-rich necrotic core with a thin and inflamed fibrous cap, so-called thin-cap fibroatheroma (TCFA) ( Figure 1 ).3,4 Other common features include expansive remodelling, large plaque size, plaque haemorrhage ...
Yla-Herttuala, S., Bentzon, J.F., Daemen, M., Falk, E., Garcia-Garcia, H.M., Herrmann, J., Hoefer, I., Jauhiainen, S., Jukema, J.W., Krams, R., Kwak, B.R., Marx, N., Naruszewicz, M., Newby, A., Pasterkamp, G., Serruys, P.W.J.C., Waltenberger, J., Weber, C., Tokgozoglu, L., ESC Working Grp Atherosclerosis Va   +19 more
openaire   +8 more sources

Macrophage death in atherosclerosis: potential role in calcification

Frontiers in Immunology, 2023
Cell death is an important aspect of atherosclerotic plaque development. Insufficient efferocytosis of death cells by phagocytic macrophages leads to the buildup of a necrotic core that impacts stability of the plaque.
Jaap G. Neels, Claire Gollentz, Giulia Chinetti   +2 more
doaj   +1 more source

miR-150-5p affects AS plaque with ASMC proliferation and migration by STAT1

Open Medicine, 2021
We explore miR‐150‐5p in atherosclerosis (AS). The AS model was constructed using Apo E−/− mice with an injection of the miR-150-5p mimic or an inhibitor.
Bian Yuan, Cai Wenqiang, Lu Hongying, Tang Shuhong, Yang Keqin, Tan Yan   +5 more
doaj   +1 more source

Treatment of advanced atherosclerotic mice with ABT-263 reduced indices of plaque stability and increased mortality. [PDF]

JCI Insight
Karnewar S, Karnewar V, Shankman LS, Owens GK.   +3 more
europepmc   +2 more sources

Stabilization of high-risk plaques [PDF]

Cardiovascular Diagnosis and Therapy, 2016
The prevalence of atherosclerotic cardiovascular diseases (ASCVDs) is increasing globally and they have become the leading cause of death in most countries. Numerous experimental and clinical studies have been conducted to identify major risk factors and effective control strategies for ASCVDs.
Bo Zhang, Keijiro Saku, Shin-ichiro Miura, Satoshi Imaizumi, Kohei Takata   +4 more
openaire   +3 more sources

Clinical Utility of the Serum Level of Lipoprotein-Related Phospholipase A2 in Acute Ischemic Stroke With Cerebral Artery Stenosis

Frontiers in Neurology, 2021
We aimed to study the clinical utility of serum lipoprotein-associated phospholipase A2 (Lp-PLA2) in acute ischemic stroke (AIS) with cerebral artery stenosis (CAS). We included 200 AIS patients and 90 healthy controls in this study.
Jing Cao, Ping Yan, Yajun Zhou, Xia Zhou, Zhongwu Sun, Xiao-Qun Zhu   +5 more
doaj   +1 more source

A New Paradigm for Plaque Stabilization [PDF]

Circulation, 2002
Abstract: The concept of plaque stabilization was developed to explain how lipid lowering could decrease adverse coronary events without a substantial reduction in the regression of atherosclerosis.
John A. Ambrose, Eulogio E. Martinez
openaire   +3 more sources

Macrophage anti-inflammatory behaviour in a multiphase model of atherosclerotic plaque development [PDF]

Bull Math Biol 85, 37 (2023), 2022
Atherosclerosis is an inflammatory disease characterised by the formation of plaques, which are deposits of lipids and cholesterol-laden macrophages that form in the artery wall. The inflammation is often non-resolving, due in large part to changes in normal macrophage anti-inflammatory behaviour that are induced by the toxic plaque microenvironment ...
arxiv   +1 more source

Biomechanical factors and macrophages in plaque stability [PDF]

Cardiovascular Research, 2013
Thin-cap fibroatheromas (TCFAs) or vulnerable atherosclerotic plaques are considered a high-risk phenotype for acute cardiovascular events. TCFAs are identified by a thin rupture-prone fibrous cap, a large necrotic core, and a high content of leucocytes. Atherogenesis is dependent upon complex patterns of blood flow.
Seneviratne, A, Hulsmans, M, Holvoet, P, Monaco, C   +3 more
openaire   +3 more sources