Anti‐atherosclerotic effect of the angiotensin 1–7 mimetic AVE0991 is mediated by inhibition of perivascular and plaque inflammation in early atherosclerosis [PDF]
, 2017 Background and Purpose: Inflammation plays a key role in atherosclerosis. A protective role of angiotensin-(1-7) in vascular pathologies opened a possibility for therapeutic use of small molecule non-peptide Ang-(1-7) mimetics, such as AVE0991.
Czesnikiewicz-Guzik, M. +11 more
core +2 more sources
A New Paradigm for Plaque Stabilization [PDF]
Circulation, 2002 Abstract: The concept of plaque stabilization was developed to explain how lipid lowering could decrease adverse coronary events without a substantial reduction in the regression of atherosclerosis.
John A, Ambrose, Eulogio E, Martinez
openaire +2 more sources
A novel profluorescent dinitroxide for imaging polypropylene degradation [PDF]
, 2008 Free-radical processes underpin the thermo-oxidative degradation of polyolefins. Thus, to extend the lifetime of these polymers, stabilizers are generally added during processing to scavenge the free radicals formed as the polymer degrades.
Fairfull-Smith, Kathryn E. +4 more
core +2 more sources
Biomechanical factors and macrophages in plaque stability [PDF]
Cardiovascular Research, 2013 Thin-cap fibroatheromas (TCFAs) or vulnerable atherosclerotic plaques are considered a high-risk phenotype for acute cardiovascular events. TCFAs are identified by a thin rupture-prone fibrous cap, a large necrotic core, and a high content of leucocytes. Atherogenesis is dependent upon complex patterns of blood flow.
Anusha N. Seneviratne +3 more
openalex +3 more sources
How to stabilize unstable plaque [PDF]
Cardiovascular Research, 2011 This editorial refers to ‘Inhibition of rupture of established atherosclerotic plaques by treatment with apolipoprotein A-I’ by G.J. Reimers et al. , doi:10.1093/cvr/cvr057 Association studies and epidemiological observations have shown that high plasma levels of high-density lipoprotein-cholesterol (HDL-C) provide cardiovascular protection.1 The ...
openaire +2 more sources
Klotho protects against chronic kidney disease-associated atherosclerotic plaque vulnerability in
Di-san junyi daxue xuebao, 2020 Objective To explore the effects of chronic kidney disease (CKD) on the instability of atherosclerotic plaques and investigate the role of Klotho in this pathological process.
BI Xianjin +4 more
doaj +1 more source
Endothelial-to-Mesenchymal Transition in Atherosclerosis: Friend or Foe?
Cells, 2022 Despite many decades of research, complications of atherosclerosis resulting from the rupture or erosion of unstable plaques remain the leading cause of death worldwide.
Sarin Gole +4 more
doaj +1 more source
Bolstering cholesteryl ester hydrolysis in liver: A hepatocyte-targeting gene delivery strategy for potential alleviation of atherosclerosis [PDF]
, 2017 Current atherosclerosis treatment strategies primarily focus on limiting further cholesteryl esters (CE) accumulation by reducing endogenous synthesis of cholesterol in the liver.
Ghosh, Shobha +5 more
core +2 more sources
Frontiers in Pharmacology, 2017 Inflammatory mechanisms are involved in the process of atherosclerotic plaque formation and rupture. Accumulating evidence suggests that protease-activated receptor (PAR)-2 contributes to the pathophysiology of chronic inflammation on the vasculature. To
Pengfei Zuo +6 more
doaj +1 more source
The E3 Ubiquitin Ligase Peli1 Deficiency Promotes Atherosclerosis Progression
Cells, 2022 Background: Atherosclerosis is a chronic inflammatory vascular disease and the main cause of death and morbidity. Emerging evidence suggests that ubiquitination plays an important role in the pathogenesis of atherosclerosis including control of vascular ...
Fabienne Burger +4 more
doaj +1 more source